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Oxymorphone Opioid Agonist Action Pathway
smpdb.ca/view/SMP0125021Drug actionOxymorphone is an opioid analgesic used in the management of moderate-to-severe pain and for analgesic therapies. Oxymorphone binds to mu opioid receptors, stimulating the exchange of GTP for GDP on the G-protein complex. As the effector...
Drugs: ATP · Oxymorphone · Calcium · Magnesium cation · Cyclic adenosine monophosphate · gamma-Aminobutyric acid +2 moreEnzymes: Gamma-aminobutyric acid receptor subunit gamma-2, Gamma-aminobutyric acid type B receptor subunit 2Tapentadol Opioid Agonist Action Pathway
smpdb.ca/view/SMP0126806Drug actionTapentadol is a synthetic analgesic opioid with dual mechanism of action as a mu opioid agonist, and a norepinephrine reuptake inhibtor. It is an agonist of mu, kappa, and delta opioid receptors. It is also a weak serotonin reuptake inhi...
Drugs: ATP · Calcium · Magnesium cation · Cyclic adenosine monophosphate · gamma-Aminobutyric acid · Pyrophosphoric acid +2 moreEnzymes: Gamma-aminobutyric acid receptor subunit gamma-2, Gamma-aminobutyric acid type B receptor subunit 2Dextropropoxyphene Opioid Agonist Action Pathway
smpdb.ca/view/SMP0126814Drug actionDextropropoxyphene is an opioid analgesic used to treat mild to moderate pain. It is withdrawn in Europe and the United States due to the risk of cardiac arrhythmias and overdose, possibly leading to death. Dextropropoxyphene is taken or...
Drugs: ATP · Dextropropoxyphene · Calcium · Magnesium cation · Cyclic adenosine monophosphate · gamma-Aminobutyric acid +2 moreEnzymes: Gamma-aminobutyric acid receptor subunit gamma-2, Gamma-aminobutyric acid type B receptor subunit 23-Methylthiofentanyl Opioid Agonist Action Pathway
smpdb.ca/view/SMP0125012Drug action3-Methyl-thiofentanyl is a fentanyl analog and an opioid analgesic that works by inducing central nervous system (CNS) depression. 3-Methylthiofentanyl binds to the mu, delta, and kappa opioid receptors. These ultimately lead to decrease...
Drugs: ATP · Calcium · Magnesium cation · 3-Methylthiofentanyl · Cyclic adenosine monophosphate · gamma-Aminobutyric acid +2 moreEnzymes: Gamma-aminobutyric acid receptor subunit gamma-2, Gamma-aminobutyric acid type B receptor subunit 2Methadyl acetate Opioid Agonist Action Pathway
smpdb.ca/view/SMP0126792Drug actionMethadyl acetate is a narcotic analgesic with a long onset and duration of action, used to treat narcotic dependence. Methadyl acetate binds to mu opioid receptors, stimulating the exchange of GTP for GDP on the G-protein complex. As the...
Drugs: ATP · Calcium · Magnesium cation · Methadyl acetate · Cyclic adenosine monophosphate · gamma-Aminobutyric acid +2 moreEnzymes: Gamma-aminobutyric acid receptor subunit gamma-2, Gamma-aminobutyric acid type B receptor subunit 2Sufentanil Opioid Agonist Action Pathway
smpdb.ca/view/SMP0125019Drug actionSufentanil is an opioid used to induce and maintain anesthesia, to act as an analgesic in labor and delivery, and to treat severe, acute pain. It is used as an adjunct in anesthesia, in balanced anesthesia, and as a primary anesthetic ag...
Drugs: ATP · Sufentanil · Calcium · Magnesium cation · Cyclic adenosine monophosphate · gamma-Aminobutyric acid +2 moreEnzymes: Gamma-aminobutyric acid receptor subunit gamma-2, Gamma-aminobutyric acid type B receptor subunit 2Oxycodone Opioid Agonist Action Pathway
smpdb.ca/view/SMP0125024Drug actionOxycodone is an opioid used in the management of moderate to severe pain. There is also an extended release formulation indicated for chronic moderate to severe pain requiring continuous opioid analgesics for an extended period. Oxycodon...
Drugs: ATP · Oxycodone · Calcium · Magnesium cation · Cyclic adenosine monophosphate · gamma-Aminobutyric acid +2 moreEnzymes: Gamma-aminobutyric acid receptor subunit gamma-2, Gamma-aminobutyric acid type B receptor subunit 2Dextromoramide Opioid Agonist Action Pathway
smpdb.ca/view/SMP0126815Drug actionDextromoramide is an opioid analgesic structurally related to methadone. It is used to treat severe pain. Dextromoramide binds to mu, kappa, and delta opioid receptors on presynaptic neuron membranes, stimulating the exchange of GTP for ...
Drugs: ATP · Calcium · Magnesium cation · Dextromoramide · Cyclic adenosine monophosphate · gamma-Aminobutyric acid +2 moreEnzymes: Gamma-aminobutyric acid receptor subunit gamma-2, Gamma-aminobutyric acid type B receptor subunit 2Ethylmorphine Opioid Action Pathway
smpdb.ca/view/SMP0125015Drug actionEthylmorphine is an opioid analgesic and antitussive agent used to reduce coughs caused by colds and lung infections in combination with codeine. Ethylmorphine is taken orally and after being absorbed from the intestine is sent to the li...
Drugs: ATP · Morphine · Calcium · Magnesium cation · Ethylmorphine · Cyclic adenosine monophosphate +3 moreEnzymes: Gamma-aminobutyric acid receptor subunit gamma-2, Gamma-aminobutyric acid type B receptor subunit 2Morphine Opioid Agonist Brain Action Pathway
smpdb.ca/view/SMP0126791Drug actionMorphine is an opioid agonist used for the relief of moderate to severe acute and chronic pain. Morphine can be administered orally as a capsule or tablet, intravenously, intrathecally, or as an epidural. Morphine-6-glucuronide, a metabo...
Drugs: ATP · Morphine · Calcium · Magnesium cation · Cyclic adenosine monophosphate · gamma-Aminobutyric acid +1 moreEnzymes: Gamma-aminobutyric acid receptor subunit gamma-2, Gamma-aminobutyric acid type B receptor subunit 2