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Retinoic acid receptor RXR-beta
go.drugbank.com/bio_entities/BE0000078TargetHumansRetinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes … The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE)
Polypeptides: Retinoic acid receptor RXR-betaPolyunsaturated fatty acid 5-lipoxygenase
go.drugbank.com/bio_entities/BE0000248TargetEnzymeHumansIt does not catalyze the oxygenation of linoleic acid and does not convert (5S)-HETE to lipoxin isomers (PubMed:31664810). … May also play a role in glucose homeostasis, regulation of insulin secretion and palmitic acid-induced insulin resistance via AMPK (By similarity).
Polypeptides: Polyunsaturated fatty acid 5-lipoxygenasePolyunsaturated fatty acid lipoxygenase ALOX15
go.drugbank.com/bio_entities/BE0000309TargetEnzymeHumansIn addition to its role in the immune and inflammatory responses, this enzyme may play a role in epithelial wound healing in the cornea through production of lipoxin A4 (LXA(4)) and docosahexaenoic acid-derived … Can convert epoxy fatty acids to hydroperoxy-epoxides derivatives followed by an intramolecular nucleophilic substitution leading to the formation of monocyclic endoperoxides (PubMed:25293588).
Polypeptides: Polyunsaturated fatty acid lipoxygenase ALOX15Retinoic acid receptor RXR-alpha
go.drugbank.com/bio_entities/BE0000412TargetHumansForms homo- or heterodimers with retinoic acid receptors (RARs) and binds to target response elements in response to their ligands, all-trans or 9-cis retinoic acid, to regulate gene expression in various … The RXRA/PPARA heterodimer is required for PPARA transcriptional activity on fatty acid oxidation genes such as ACOX1 and the P450 system genes (PubMed:10195690).
Polypeptides: Retinoic acid receptor RXR-alphaRetinoic acid receptor RXR-gamma
go.drugbank.com/bio_entities/BE0000707TargetHumansRetinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes … The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5.
Polypeptides: Retinoic acid receptor RXR-gammaAlpha-1-acid glycoprotein 1
go.drugbank.com/bio_entities/BE0000925CarrierTargetHumansAlso binds synthetic drugs and influences their distribution and availability in the body. Appears to function in modulating the activity of the immune system during the acute-phase reaction
Polypeptides: Alpha-1-acid glycoprotein 1Excitatory amino acid transporter 1
go.drugbank.com/bio_entities/BE0001115TargetTransporterHumansMediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (PubMed:20477940). … Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:20477940, PubMed:26690923, PubMed:28032905, PubMed:28424515,
Polypeptides: Excitatory amino acid transporter 1Fatty acid-binding protein, heart
go.drugbank.com/bio_entities/BE0001201CarrierHumansFABPs are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters
Polypeptides: Fatty acid-binding protein, heartSynonyms: Fatty acid-binding protein 3, Muscle fatty acid-binding proteinFatty-acid amide hydrolase 1
go.drugbank.com/bio_entities/BE0002194TargetEnzymeHumansFAAH cooperates with PM20D1 in the hydrolysis of amino acid-conjugated fatty acids such as N-fatty acyl glycine and N-fatty acyl-L-serine, thereby acting as a physiological regulator of specific subsets … Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates (PubMed:17015445, PubMed:9122178).
Polypeptides: Fatty-acid amide hydrolase 1Synonyms: Fatty acid ester hydrolaseExcitatory amino acid transporter 5
go.drugbank.com/bio_entities/BE0002267TargetHumansSodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate. … Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion (PubMed:9108121).
Polypeptides: Excitatory amino acid transporter 5