Alpha-1-acid glycoprotein 1

Details

Name
Alpha-1-acid glycoprotein 1
Kind
protein
Synonyms
  • AGP 1
  • AGP1
  • OMD 1
  • Orosomucoid-1
Gene Name
ORM1
UniProtKB Entry
P02763Swiss-Prot
Organism
Humans
NCBI Taxonomy ID
9606
Amino acid sequence
>lcl|BSEQ0055618|Alpha-1-acid glycoprotein 1
MALSWVLTVLSLLPLLEAQIPLCANLVPVPITNATLDRITGKWFYIASAFRNEEYNKSVQ
EIQATFFYFTPNKTEDTIFLREYQTRQDQCIYNTTYLNVQRENGTISRYVGGQEHFAHLL
ILRDTKTYMLAFDVNDEKNWGLSVYADKPETTKEQLGEFYEALDCLRIPKSDVVYTDWKK
DKCEPLEKQHEKERKQEEGES
Number of residues
201
Molecular Weight
23539.43
Theoretical pI
4.66
GO Classification
Processes
positive regulation of interleukin-1 beta production / positive regulation of interleukin-1 production / positive regulation of tumor necrosis factor production
Components
collagen-containing extracellular matrix / platelet alpha granule lumen / specific granule lumen / tertiary granule lumen
General Function
Functions as a transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain. Also binds synthetic drugs and influences their distribution and availability in the body. Appears to function in modulating the activity of the immune system during the acute-phase reaction
Specific Function
Not Available
Pfam Domain Function
Signal Regions
1-18
Transmembrane Regions
Not Available
Cellular Location
Secreted
Gene sequence
>lcl|BSEQ0010649|Alpha-1-acid glycoprotein 1 (ORM1)
ATGGCGCTGTCCTGGGTTCTTACAGTCCTGAGCCTCCTACCTCTGCTGGAAGCCCAGATC
CCATTGTGTGCCAACCTAGTACCGGTGCCCATCACCAACGCCACCCTGGACCGGATCACT
GGCAAGTGGTTTTATATCGCATCGGCCTTTCGAAACGAGGAGTACAATAAGTCGGTTCAG
GAGATCCAAGCAACCTTCTTTTACTTCACCCCCAACAAGACAGAGGACACGATCTTTCTC
AGAGAGTACCAGACCCGACAGGACCAGTGCATCTATAACACCACCTACCTGAATGTCCAG
CGGGAAAATGGGACCATCTCCAGATACGTGGGAGGCCAAGAGCATTTCGCTCACTTGCTG
ATCCTCAGGGACACCAAGACCTACATGCTTGCTTTTGACGTGAACGATGAGAAGAACTGG
GGGCTGTCTGTCTATGCTGACAAGCCAGAGACGACCAAGGAGCAACTGGGAGAGTTCTAC
GAAGCTCTCGACTGCTTGCGCATTCCCAAGTCAGATGTCGTGTACACCGATTGGAAAAAG
GATAAGTGTGAGCCACTGGAGAAGCAGCACGAGAAGGAGAGGAAACAGGAGGAGGGGGAA
TCCTAG
Chromosome Location
9
Locus
9q32
External Identifiers
ResourceLink
UniProtKB IDP02763
UniProtKB Entry NameA1AG1_HUMAN
GenBank Protein ID757907
GenBank Gene IDX02544
GeneCard IDORM1
GenAtlas IDORM1
HGNC IDHGNC:8498
PDB ID(s)3KQ0
KEGG IDhsa:5004
NCBI Gene ID5004
General References
  1. Dente L, Pizza MG, Metspalu A, Cortese R: Structure and expression of the genes coding for human alpha 1-acid glycoprotein. EMBO J. 1987 Aug;6(8):2289-96. [Article]
  2. Board PG, Jones IM, Bentley AK: Molecular cloning and nucleotide sequence of human alpha 1 acid glycoprotein cDNA. Gene. 1986;44(1):127-31. [Article]
  3. Dente L, Ciliberto G, Cortese R: Structure of the human alpha 1-acid glycoprotein gene: sequence homology with other human acute phase protein genes. Nucleic Acids Res. 1985 Jun 11;13(11):3941-52. [Article]
  4. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [Article]
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  6. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
  7. Schmid K, Kaufmann H, Isemura S, Bauer F, Emura J, Motoyama T, Ishiguro M, Nanno S: Structure of 1 -acid glycoprotein. The complete amino acid sequence, multiple amino acid substitutions, and homology with the immunoglobulins. Biochemistry. 1973 Jul 3;12(14):2711-24. [Article]
  8. Ikenaka T, Ishiguro M, Emura J, Kaufmann H, Isemura S, Bauer W, Schmid K: Isolation and partial characterization of the cyanogen bromide fragments of 1 -acid glycoprotein and the elucidation of the amino acid sequence of the carboxyl-terminal cyanogen bromide fragment. Biochemistry. 1972 Sep 26;11(20):3817-29. [Article]
  9. Schmid K, Burgi W, Collins JH, Nanno S: The disulfide bonds of alpha1-acid glycoprotein. Biochemistry. 1974 Jun 18;13(13):2694-7. [Article]
  10. Treuheit MJ, Costello CE, Halsall HB: Analysis of the five glycosylation sites of human alpha 1-acid glycoprotein. Biochem J. 1992 Apr 1;283 ( Pt 1):105-12. [Article]
  11. Zhang H, Li XJ, Martin DB, Aebersold R: Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry. Nat Biotechnol. 2003 Jun;21(6):660-6. Epub 2003 May 18. [Article]
  12. Hagglund P, Bunkenborg J, Elortza F, Jensen ON, Roepstorff P: A new strategy for identification of N-glycosylated proteins and unambiguous assignment of their glycosylation sites using HILIC enrichment and partial deglycosylation. J Proteome Res. 2004 May-Jun;3(3):556-66. [Article]
  13. Kristiansen TZ, Bunkenborg J, Gronborg M, Molina H, Thuluvath PJ, Argani P, Goggins MG, Maitra A, Pandey A: A proteomic analysis of human bile. Mol Cell Proteomics. 2004 Jul;3(7):715-28. Epub 2004 Apr 14. [Article]
  14. Bunkenborg J, Pilch BJ, Podtelejnikov AV, Wisniewski JR: Screening for N-glycosylated proteins by liquid chromatography mass spectrometry. Proteomics. 2004 Feb;4(2):454-65. [Article]
  15. Liu T, Qian WJ, Gritsenko MA, Camp DG 2nd, Monroe ME, Moore RJ, Smith RD: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. J Proteome Res. 2005 Nov-Dec;4(6):2070-80. [Article]
  16. Fitos I, Visy J, Zsila F, Mady G, Simonyi M: Selective binding of imatinib to the genetic variants of human alpha1-acid glycoprotein. Biochim Biophys Acta. 2006 Nov;1760(11):1704-12. Epub 2006 Aug 25. [Article]
  17. Ramachandran P, Boontheung P, Xie Y, Sondej M, Wong DT, Loo JA: Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry. J Proteome Res. 2006 Jun;5(6):1493-503. [Article]
  18. Zsila F, Iwao Y: The drug binding site of human alpha1-acid glycoprotein: insight from induced circular dichroism and electronic absorption spectra. Biochim Biophys Acta. 2007 May;1770(5):797-809. Epub 2007 Jan 28. [Article]
  19. Chen R, Jiang X, Sun D, Han G, Wang F, Ye M, Wang L, Zou H: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. J Proteome Res. 2009 Feb;8(2):651-61. doi: 10.1021/pr8008012. [Article]
  20. Nilsson J, Ruetschi U, Halim A, Hesse C, Carlsohn E, Brinkmalm G, Larson G: Enrichment of glycopeptides for glycan structure and attachment site identification. Nat Methods. 2009 Nov;6(11):809-11. doi: 10.1038/nmeth.1392. Epub 2009 Oct 18. [Article]
  21. Halim A, Nilsson J, Ruetschi U, Hesse C, Larson G: Human urinary glycoproteomics; attachment site specific analysis of N- and O-linked glycosylations by CID and ECD. Mol Cell Proteomics. 2012 Apr;11(4):M111.013649. doi: 10.1074/mcp.M111.013649. Epub 2011 Dec 14. [Article]
  22. Schonfeld DL, Ravelli RB, Mueller U, Skerra A: The 1.8-A crystal structure of alpha1-acid glycoprotein (Orosomucoid) solved by UV RIP reveals the broad drug-binding activity of this human plasma lipocalin. J Mol Biol. 2008 Dec 12;384(2):393-405. doi: 10.1016/j.jmb.2008.09.020. Epub 2008 Sep 16. [Article]
  23. Yuasa I, Umetsu K, Vogt U, Nakamura H, Nanba E, Tamaki N, Irizawa Y: Human orosomucoid polymorphism: molecular basis of the three common ORM1 alleles, ORM1*F1, ORM1*F2, and ORM1*S. Hum Genet. 1997 Mar;99(3):393-8. [Article]

Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
Disopyramideapprovednocarrierother/unknownDetails
Tamsulosinapproved, investigationalnocarrierDetails
Quinidineapproved, investigationalunknowncarrierbinderDetails
Phenprocoumonapproved, investigationalnocarrierDetails
Penbutololapproved, investigationalunknowncarrierother/unknownDetails
AprindineexperimentalunknowncarrierDetails
Acenocoumarolapproved, investigationalnocarrierDetails
WarfarinapprovednocarrierDetails
Alfentanilapproved, illicitunknowncarrierDetails
NortriptylineapprovednocarrierbinderDetails
AmitriptylineapprovednocarrierbinderDetails
Saquinavirapproved, investigationalunknowncarrierDetails
Olanzapineapproved, investigationalnocarrierbinderDetails
AmoxapineapprovednocarrierDetails
PrazosinapprovednocarriersubstrateDetails
Propranololapproved, investigationalnocarrierDetails
ImipramineapprovednocarrierDetails
Desipramineapproved, investigationalnocarrierDetails
Nomifensineapproved, withdrawnnocarrierDetails
BupropionapprovednocarrierantagonistDetails
Maprotilineapproved, investigationalnocarrierDetails
Ajmalineapproved, experimentalunknowncarrierDetails
MeperidineapprovedunknowncarrierbinderDetails
Nateglinideapproved, investigationalunknowncarrierDetails
UlipristalapprovednocarriersubstrateDetails
VandetanibapprovedunknowncarrierbinderDetails
Telaprevirapproved, withdrawnnocarriersubstrateDetails
AbirateroneapprovedunknowncarrierbinderDetails
VemurafenibapprovedunknowncarriersubstrateDetails
Vismodegibapproved, investigationalunknowncarrierbinderDetails
MirabegronapprovednocarrierbinderDetails
IvacaftorapprovednocarriercarrierDetails
PitavastatinapprovedunknowncarriersubstrateDetails
CanagliflozinapprovedunknowncarriersubstrateDetails
Erlotinibapproved, investigationalunknowncarriersubstrateDetails
Fluoxetineapproved, vet_approvedunknowncarriersubstrateDetails
Gefitinibapproved, investigationalunknowncarriersubstrateDetails
ImatinibapprovednocarrierbinderDetails
Tacrolimusapproved, investigationalunknowncarriersubstrateDetails
RiociguatapprovedunknowncarriersubstrateDetails
GrazoprevirapprovednocarriersubstrateDetails
TopiroxostatexperimentalunknowncarrierbinderDetails
Amsacrineapproved, investigationalunknowntargetDetails
Progesteroneapproved, vet_approvedunknowntargetbinderDetails
DipyridamoleapprovedunknowntargetDetails
Lidocaineapproved, vet_approvedunknowntargetDetails
Lacidipineapproved, investigationalunknowncarrierbinderDetails
ArotinololinvestigationalnocarriersubstrateDetails
AranidipineexperimentalnocarrierbinderDetails
Butambenapproved, withdrawnnocarriersubstrateDetails
Delamanidapproved, investigationalunknowncarriersubstrateDetails
Ranolazineapproved, investigationalnocarrierbinderDetails
Doxepinapproved, investigationalnocarrierbinderDetails
Dutasterideapproved, investigationalnocarrierbinderDetails
Diltiazemapproved, investigationalnocarrierbinderDetails
Raloxifeneapproved, investigationalnocarrierbinderDetails
Buspironeapproved, investigationalunknowncarrierbinderDetails
Pexidartinibapproved, investigationalunknowncarrierbinderDetails
MethadoneapprovednocarrierDetails
Metoclopramideapproved, investigationalunknowncarrierbinderDetails
Oxybutyninapproved, investigationalunknowncarrierbinderDetails
VerapamilapprovedunknowncarriersubstrateDetails
Clindamycinapproved, vet_approvedunknowncarriersubstrateDetails
ZiprasidoneapprovedunknowncarrierDetails
DarunavirapprovedunknowncarriersubstrateDetails
LopinavirapprovedunknowncarriersubstrateDetails
Ritonavirapproved, investigationalunknowncarriersubstrateDetails
Pitolisantapproved, investigationalnocarrierbinderDetails
Risperidoneapproved, investigationalunknowncarrierbinderDetails
Lurbinectedinapproved, investigationalunknowncarrierbinderDetails
Relugolixapproved, investigationalunknowncarrierbinderDetails
Tepotinibapproved, investigationalunknowncarrierbinderDetails
Alfuzosinapproved, investigationalunknowncarrierbinderDetails
Temozolomideapproved, investigationalnocarrierbinderDetails
AvanafilapprovedunknowncarrierbinderDetails
Daptomycinapproved, investigationalnocarrierbinderDetails
Estetrolapproved, investigationalunknowncarrierbinderDetails
Lincomycinapproved, vet_approvednocarrierbinderDetails
Belumosudilapproved, investigationalnocarrierbinderDetails
Sirolimusapproved, investigationalnocarrierbinderDetails
Maribavirapproved, investigationalnocarrierbinderDetails
OlaparibapprovedunknowncarrierbinderDetails
NelfinavirapprovednocarrierbinderDetails
RopivacaineapprovednocarrierbinderDetails
Atropineapproved, vet_approvedunknowncarrierbinderDetails
Futibatinibapproved, investigationalnocarrierbinderDetails
Vonoprazanapproved, investigationalunknowncarrierbinderDetails
Cobimetinibapproved, investigationalnocarrierbinderDetails
ClozapineapprovednocarrierbinderDetails
Clobazamapproved, illicitnocarrierbinderDetails
Midazolamapproved, illicitnocarrierbinderDetails
Brexpiprazoleapproved, investigationalnocarriersubstrateDetails
Fluticasone furoateapprovednocarrierbinderDetails
UmeclidiniumapprovedunknowncarrierbinderDetails
MelphalanapprovedunknowncarrierbinderDetails
BedaquilineapprovednocarrierbinderDetails
Iptacopanapproved, investigationalyescarrierbinderDetails