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Protein phosphatase 1 regulatory subunit 15A
go.drugbank.com/bio_entities/BE0011888TargetHumansPlays an essential role in autophagy by tuning translation during starvation, thus enabling lysosomal biogenesis and a sustained autophagic flux (PubMed:32978159). … Also acts a viral restriction factor by attenuating HIV-1 and influenza A virus replication (PubMed:31778897, PubMed:41747053).
Synonyms: Growth arrest and DNA damage-inducible protein GADD34Alpha-2-macroglobulin
go.drugbank.com/bio_entities/BE0000910TargetCarrierHumansFollowing cleavage in the bait region, a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase
Synonyms: C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1
go.drugbank.com/bio_entities/BE0000931TargetHumansHas ADP-ribosyltransferase activity toward GLP1R
Synonyms: ADP-ribosyltransferase C2 and C3 toxin-like 1SPARC
go.drugbank.com/bio_entities/BE0002145TargetHumansBinds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. … There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity
Synonyms: Secreted protein acidic and rich in cysteineZinc transporter ZIP4
go.drugbank.com/bio_entities/BE0009894TransporterHumansAlso exhibits polyspecific binding and transport of Cu(2+), Cd(2+) and possibly Ni(2+) but at higher concentrations (PubMed:22242765, PubMed:31914589) … Plays an essential role for dietary zinc uptake from small intestine (By similarity). The Zn(2+) uniporter activity is regulated by zinc availability (PubMed:17202136, PubMed:32348750).
Synonyms: Zrt- and Irt-like protein 4Zinc transporter ZIP3
go.drugbank.com/bio_entities/BE0009904TransporterHumansTransporter for the divalent cation Zn(2+). Mediates the influx of Zn(2+) into cells from extracellular space. Controls Zn(2+) accumulation into dentate gyrus granule cells in the hippocampus. Mediates Zn(2+) reuptake from the secreted m...
Synonyms: Zrt- and Irt-like protein 3Zinc transporter ZIP9
go.drugbank.com/bio_entities/BE0009905TransporterHumansThis pathway contributes to CLDN1 and CLDN5 expression and tight junction formation between adjacent Sertoli cells (By similarity). … Transports zinc ions across cell and organelle membranes into the cytoplasm and regulates intracellular zinc homeostasis (PubMed:19420709, PubMed:25014355, PubMed:28219737).
Synonyms: Zrt- and Irt-like protein 9Interphotoreceptor matrix proteoglycan 2
go.drugbank.com/bio_entities/BE0004942TargetHumansChondroitin sulfate- and hyaluronan-binding proteoglycan involved in the organization of interphotoreceptor matrix; may participate in the maturation and maintenance of the light-sensitive photoreceptor
Synonyms: Sialoprotein associated with cones and rods proteoglycanTransient receptor potential cation channel subfamily M member 5
go.drugbank.com/bio_entities/BE0020643TargetHumansdiacylglycerol (DAG) and inositol trisphosphate (IP3), IP3 binds to its receptors in the endoplasmic reticulum and cause calcium release. … Monovalent cation-selective ion channel activated by intracellular Ca(2+) in a voltage- and temperature-dependent manner (PubMed:14634208).
Synonyms: MLSN1- and TRP-related gene 1 proteinHydroxyproline dehydrogenase
go.drugbank.com/bio_entities/BE0020644EnzymeHumansDoes not react with other diastereomers of Hyp: trans-4-D-hydroxyproline and cis-4-L-hydroxyproline. … Ubiquininone analogs such as menadione, duroquinone and ubiquinone-1 react more efficiently than oxygen as the terminal electron acceptor during catalysis
Synonyms: Kidney and liver proline oxidase 1