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Esomeprazole Action Pathway
smpdb.ca/view/SMP0123196Drug actionThe bicarbonate ions go into the blood via the chloride anion exchanger on the basolateral membrane which exchanges the hydrogen bicarbonate for Cl- ions.
Enzymes: Chloride anion exchanger, Potassium-transporting ATPase alpha chain 1Lansoprazole Action Pathway
smpdb.ca/view/SMP0123261Drug actionThe bicarbonate ions go into the blood via the chloride anion exchanger on the basolateral membrane which exchanges the hydrogen bicarbonate for Cl- ions.
Enzymes: Chloride anion exchanger, Potassium-transporting ATPase alpha chain 1Nizatidine Action Pathway
smpdb.ca/view/SMP0000233Drug actionNizatidine (also known as Axid or Acinon) is a histamine H2 receptor antagonist, that can bind to histamine H2 receptor on gastric basolateral membrane, which can reduce the gastric acid response. Blocking of histamine binding to histami...
Enzymes: Chloride intracellular channel protein 2, Potassium-transporting ATPase alpha chain 1Metiamide Action Pathway
smpdb.ca/view/SMP0000735Drug actionMetiamide is a histamine H2-receptor antagonist that can bind and inhibit histamine H2-receptor to prevent the histamine effects on basolateral memrbane in gastric parietal cell. Binding and inhibition of histamine H2-receptor can lead t...
Enzymes: Chloride intracellular channel protein 2, Potassium-transporting ATPase alpha chain 1Ethacrynic Acid Diuretic Action Pathway
smpdb.ca/view/SMP0124515Drug actionEthacrynic acid may also inhibit sodium and chloride reabsorption in the proximal and distal tubules.
Enzymes: Chloride channel protein ClC-Ka, Sodium/potassium-transporting ATPase subunit alpha-1Kidney Function - Distal Convoluted Tubule
smpdb.ca/view/SMP0121012PhysiologicalIn addition, sodium, chlorine, and calcium are also reabsorbed back into the systemic circulation via their respective channels and exchangers. … As a result, a high concentration of sodium, chlorine, and calcium in the blood vessels occurs. The reabsorption of ions and water increases blood fluid volume and blood pressure.
Enzymes: Chloride channel protein ClC-Ka, Potassium-transporting ATPase alpha chain 1Kidney Function - Ascending Limb of The Loop of Henle
smpdb.ca/view/SMP0121010PhysiologicalChloride, potassium, and sodium are co-transported across the apical membrane (closest to the lumen) via transporters from the filtrate. … In addition, the three ions are transported across the basolateral membrane (closest to the renal interstitium) via other means such as the sodium potassium ATPase transports and the chloride channels
Enzymes: Chloride channel protein ClC-Ka, Sodium/potassium-transporting ATPase subunit alpha-1Triamterene Action Pathway (New)
smpdb.ca/view/SMP0126281Drug actionTriamterene maintains or increases sodium excretion, thereby increasing the excretion of water, and reducing the excess loss of potassium, hydrogen, and chloride ions by inhibiting the distal tubular exchange … This reduces the driving force for potassium movement into the tubular lumen and thus decreases potassium excretion.
Enzymes: Chloride channel protein ClC-Ka, Sodium/potassium-transporting ATPase subunit alpha-1Quinethazone Action Pathway
smpdb.ca/view/SMP0123030Drug actionIn the distal convoluted tubule (DCT), the regulation of ions such as sodium, potassium, calcium, chloride, and magnesium occurs. … transporter which transports chloride into the interstitium-blood.
Enzymes: Chloride channel protein ClC-Ka, Sodium/potassium-transporting ATPase subunit alpha-1Indapamide Diuretic Action Pathway
smpdb.ca/view/SMP0123031Drug actionIn the distal convoluted tubule (DCT), the regulation of ions such as sodium, potassium, calcium, chloride, and magnesium occurs. … transporter which transports chloride into the interstitium-blood.
Enzymes: Chloride channel protein ClC-Ka, Sodium/potassium-transporting ATPase subunit alpha-1