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Trabectedin
go.drugbank.com/drugs/DB05109ApprovedInvestigationalIt is approved for use in Europe, Russia and South Korea for the treatment of advanced soft tissue sarcoma. … It is currently under evaluation for the treatment of breast cancer, prostate cancer, in addition to pediatric sarcomas. Both the European Commission and the U.S.
Categories: Cytochrome P-450 CYP2C19 Substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP2C9 Substrates with a Narrow Therapeutic IndexProducts: Yolisar 1 mg I.V. İnfüzyonluk Çözelti Hazırlamada Kullanılacak Konsantre İçin Toz, 1 ADET, YONDELIS® 1MG POLVO LIOFILIZADO PARA INYECCIÓNTalc
go.drugbank.com/drugs/DB09511ApprovedInvestigationalTalc is a mineral composed primarily of magnesium, silicon and oxygen. … It is a substance often found in cosmetic and personal hygiene products including baby powder, adult body powders and facial powders.
Synonyms: E-553(III)Categories: Compounds used in a research, industrial, or household settingBaricitinib
go.drugbank.com/drugs/DB11817ApprovedInvestigational[A248400] The EC later approved baricitinib for the treatment of atopic dermatitis, making it the first JAK inhibitor used for this indication in Europe. … Baricitinib is a Janus kinase (JAK) inhibitor. JAKs are tyrosine protein kinases that play an important role in pro-inflammatory signaling pathways.
Categories: MATE 2 Substrates with a Narrow Therapeutic Index, P-glycoprotein substrates with a Narrow Therapeutic IndexProducts: UNAMİTY 4 MG FİLM KAPLI TABLET, 7 ADET, UNAMİTY 2 MG FİLM KAPLI TABLET, 7 ADETFlubendazole
go.drugbank.com/drugs/DB08974ApprovedInvestigationalWithdrawnFlubendazole is an anthelmintic that is used to treat worm infection in humans. It is available OTC in Europe.
Synonyms: methyl 5-(p-fluorobenzoyl)-2-benzimidazolecarbamate, (5-(4-fluorobenzoyl)-1H-benzimidazole-2-yl)carbamic acid methyl esterCategories: Heterocyclic Compounds, 2-RingZinc oxide
go.drugbank.com/drugs/DB09321ApprovedInvestigationalZinc oxide is an inorganic compound used in a number of manufacturing processes. … It occurs naturally as the mineral zincite, but most zinc oxide is produced synthetically.
Synonyms: Zinc (as oxide), Zinc (as zinc oxide)Mixtures: UNGUENTO S. LAZARO, S-Oint PRODERM SKIN PROTECTANTBrimonidine
go.drugbank.com/drugs/DB00484ApprovedInvestigational[A178951] It is considered to be a third generation alpha-2 aadrenergic receptor agonist, since it displays preferential binding at alpha-2 adrenoceptors over alpha-1 receptors. … Brimonidine is an alpha-adrenergic agonist and 2-imidazoline derivative that was first introduced in 1996.
Synonyms: 5-Bromo-6-(2-imidazolin-2-ylamino)quinoxalineMixtures: NEFRIDAXEM B+D, Brimonidine Tartrate 0.25% / Ivermectin 1% / Metronidazole 1% / Niacinamide 4%Excitatory Neural Signalling Through 5-HTR 6 and Serotonin
smpdb.ca/view/SMP0000312SignalingThe 5-HT6 receptor activates G(s) proteins which lead to the activation of adenylyl cyclase which produces the secondary messenger cAMP. cAMP activates PKA (protein kinase A) which phosphorylates downstream
Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12, Guanine nucleotide-binding protein G(s) subunit alpha isoforms shortDemecarium
go.drugbank.com/drugs/DB00944ApprovedDemecarium is an indirect-acting parasympathomimetic agent that is used to treat glaucoma. It is a cholinesterase inhibitor or an anticholinesterase. … The outflow of the aqueous humor is facilitated, which leads to a reduction in intraocular pressure.
Sultopride
go.drugbank.com/drugs/DB13273ApprovedSultopride is used in Japan, Hong Kong, and Europe to treat schizophrenia. It is of the drug class atypical antipsychotics [L5626].
Benmoxin
go.drugbank.com/drugs/DB09246ApprovedWithdrawnBenmoxin is an irreversible and nonselective monoamine oxidase inhibitor (MAOI) of the hydrazine class. It was first synthesized in 1967 and rapidly used in Europe as an antidepressant. … However, this agent is no longer marketed.