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Displaying results 901 - 910 of 10000 in total
  1. Target

    Ephrin type-A receptor 8

    go.drugbank.com/bio_entities/BE0009440
    TargetHumans

    During development of the nervous system also plays a role in axon guidance. … The GPI-anchored ephrin-A EFNA2, EFNA3, and EFNA5 are able to activate EPHA8 through phosphorylation.

    Polypeptides: Ephrin type-A receptor 8
  2. Target

    Inositol-trisphosphate 3-kinase A

    go.drugbank.com/bio_entities/BE0001627
    TargetHumans

    Catalyzes the phosphorylation of 1D-myo-inositol 1,4,5-trisphosphate (InsP3) into 1D-myo-inositol 1,3,4,5-tetrakisphosphate and participates to the regulation of calcium homeostasis

    Polypeptides: Inositol-trisphosphate 3-kinase ASynonyms: IP3K A, IP3 3-kinase A
  3. Target

    Ephrin type-A receptor 1

    go.drugbank.com/bio_entities/BE0009436
    TargetHumans

    Also plays a role in angiogenesis and regulates cell proliferation. May play a role in apoptosis … Binds with a low affinity EFNA3 and EFNA4 and with a high affinity to EFNA1 which most probably constitutes its cognate/functional ligand.

    Polypeptides: Ephrin type-A receptor 1
  4. Target

    Complement C1q subcomponent subunit A

    go.drugbank.com/bio_entities/BE0002094
    TargetHumans

    The C1Q subcomplex is activated by a hexamer of IgG complexed with antigens, while it is activated by a pentameric IgM (PubMed:19706439, PubMed:24626930, PubMed:29449492). … Core component of the complement C1 complex, a multiprotein complex that initiates the classical pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens

    Polypeptides: Complement C1q subcomponent subunit A
  5. Target

    Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial

    go.drugbank.com/bio_entities/BE0000377
    TargetHumans

    Plays a role in the maintenance of normal spermatogenesis through the reduction of fatty acid accumulation in the testes (By similarity) … Plays a role in the control of insulin secretion by inhibiting the activation of glutamate dehydrogenase 1 (GLUD1), an enzyme that has an important role in regulating amino acid-induced insulin secretion

    Polypeptides: Hydroxyacyl-coenzyme A dehydrogenase, mitochondrialSynonyms: Medium and short-chain L-3-hydroxyacyl-coenzyme A dehydrogenase
  6. Target

    Acetyl-coenzyme A synthetase, cytoplasmic

    go.drugbank.com/bio_entities/BE0000350
    TargetEnzymeHumans

    Can also utilize propionate with a much lower affinity (PubMed:38369012). Catalyzes the conversion of lactate into lactoyl-CoA (PubMed:39561764). … Acts as a chromatin-bound transcriptional coactivator that up-regulates histone acetylation and expression of neuronal genes (By similarity).

    Polypeptides: Acetyl-coenzyme A synthetase, cytoplasmic
  7. Drug

    Pegfilgrastim

    go.drugbank.com/drugs/DB00019
    ApprovedInvestigational

    [L9974] NIOPEG (pegfilgrastim), a biosimilar of NEULASTA®, was approved by Health Canada in April 2024 for the prevention of febrile neutropenia in patients with non-myeloid malignancies receiving myelosuppressive … [A29,A187607] Due to a longer half-life and slower elimination rate than filgrastim, pegfilgrastim requires less frequent dosing than filgrastim; however, pegfilgrastim has a comparable pharmacological

    Categories: Compounds used in a research, industrial, or household setting, Complex MixturesSynonyms: 吉新芬, PEG-G-CSF
  8. Drug

    Pralidoxime

    go.drugbank.com/drugs/DB00733
    ApprovedInvestigationalVet approved

    Pralidoxime is an antidote to organophosphate pesticides and chemicals. … If given within 24 hours,after organophosphate exposure, pralidoxime reactivates the enzyme cholinesterase by cleaving the phosphate-ester bond formed between the organophosphate and acetylcholinesterase

    Categories: Compounds used in a research, industrial, or household settingSynonyms: 2-PAM
  9. Drug

    Citrus bioflavonoids

    go.drugbank.com/drugs/DB14586
    Approved

    Synonyms: Hesperidin complexMixtures: Nutriforte Non-Acidic Vitamin C 1000 mg with Bioflavonoids, NATURERICH ESTER-C COMPLEX TABLETS
  10. Drug

    Bortezomib

    go.drugbank.com/drugs/DB00188
    ApprovedInvestigational

    Bortezomib is a dipeptide boronic acid derivative and proteasome inhibitor used to treat multiple myeloma and mantle cell lymphoma. … [A204083] The 26S proteasome is a protein complex that degrades ubiquitinated proteins in the ubiquitin-proteasome pathway: reversible inhibition of the 26S proteasome, leading to cell cycle arrest and

    Synonyms: N-[(1R)-1-(DIHYDROXYBORYL)-3-methylbutyl]-N-(pyrazin-2-ylcarbonyl)-L-phenylalaninamide, [(1R)-3-methyl-1-({(2S)-3-phenyl-2-[(pyrazin-2-ylcarbonyl)amino]propanoyl}amino)butyl]boronic acidCategories: P-glycoprotein substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP1A2 Substrates with a Narrow Therapeutic Index