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Noncanonical Wnt/Ca2+ signaling
smpdb.ca/view/SMP0468891SignalingThe Wnt/Ca²⁺ pathway is activated by the binding of the Wnt ligand to a Frizzled receptor.
3-dehydroquinate dehydratase
go.drugbank.com/bio_entities/BE0001819TargetSalmonella typhiInvolved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-d...
Synonyms: Type I DHQase, Type I dehydroquinaseImatinib
go.drugbank.com/drugs/DB00619ApprovedInvestigationalThe discovery of imatinib also established a new group of therapy called "targeted therapy", since treatment can be tailored specifically to the unique cancer genetics of each patient. … [L42220] Imatinib was approved on February 1st ,2001 by the FDA and November 7th, 2001 by the EMA; however, its European approval has been withdrawn in October 2023.[A263036,L49746,L49751]
Categories: P-glycoprotein inhibitors, P-glycoprotein substratesSynonyms: α-(4-methyl-1-piperazinyl)-3'-((4-(3-pyridyl)-2-pyrimidinyl)amino)-p-toluidideAcute Non-Lymphocytic Leukemia
go.drugbank.com/conditions/DBCOND0038781Drugs: TioguanineSynonyms: Acute myeloid leukemia, no ICD-O subtype (morphologic abnormality), Acute myeloid leukemia, no International Classification of Diseases for Oncology subtypeCutaneous Melanoma
go.drugbank.com/conditions/DBCOND0040978Drugs: IpilimumabSynonyms: Malignant melanoma, no ICD-O subtype, Malignant melanoma, no International Classification of Diseases for Oncology subtypeMelanoma
go.drugbank.com/conditions/DBCOND0020306Synonyms: Malignant melanoma, no ICD-O subtype, Malignant melanoma, no International Classification of Diseases for Oncology subtypeIsocarboxazid
go.drugbank.com/drugs/DB01247Approved[T115] It was first introduced by Roche pharmaceuticals, further developed by Validus pharms Inc and first FDA approved as a prescription drug on July 1st, 1959. … Isocarboxazid has the formula 1-benzyl-2-(5-methyl-3-isoxazolylcarbonyl)hydrazine-isocarboxazid. It is a monoamine oxidase inhibitor.
Categories: Monoamine Oxidase Inhibitors, Non-Selective, Monoamine Oxidase A Inhibitors for interaction with Monoamine Oxidase A substratesSulisobenzone
go.drugbank.com/drugs/DB11185ApprovedSulisobenzone is approved by the FDA in concentrations of up to 10% and in Canada, is approved by Health Canada at the same concentrations [F38]. … It works to filter out both UVA and UVB rays, protecting the skin from sun UV damage [L2153].
Salts: Benzophenone-5Mixtures: Givenchy Radically No Surgetics, Nioxin Scalp Treatment System 6 SPF 15 Sunscreen - Medium to Coarse HairProteasome subunit beta type-2
go.drugbank.com/bio_entities/BE0002349TargetHumansThis type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex) … 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no
Synonyms: Macropain subunit C7-I, Proteasome component C7-ITranscobalamin-1
go.drugbank.com/bio_entities/BE0000238TargetTransporterCarrierHumansBinds vitamin B12 with femtomolar affinity and protects it from the acidic environment of the stomach
Synonyms: TC I, Transcobalamin I