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Methazolamide
go.drugbank.com/drugs/DB00703ApprovedA carbonic anhydrase inhibitor that is used as a diuretic and in the treatment of glaucoma.
Categories: Heterocyclic Compounds, 1-RingDobutamine
go.drugbank.com/drugs/DB00841ApprovedInvestigationalA beta-1 agonist catecholamine that has cardiac stimulant action without evoking vasoconstriction or tachycardia. It is proposed as a cardiotonic after myocardial infarction or open heart surgery.
Mixtures: DOCARIP® 1 MG/MLCategories: Adrenergic alpha-1 Receptor Agonists, Adrenergic beta-1 Receptor AgonistsP2 Purinoceptors
go.drugbank.com/bio_entities/BE0009827TargetThe affinity range is UTP = ATP > ATP-gamma-S >> 2-methylthio-ATP = ADP … G protein-coupled receptor for S-geranylgeranyl-glutathione (GGG), an endogenous metabolite present in lymphoid tissues.
Polypeptides: S-geranylgeranyl-glutathione receptor P2RY8gamma-Glutamyltransferase Deficiency
smpdb.ca/view/SMP0000183DiseaseGamma-Glutamyltransferase Deficiency is an autosomal recessive disorder caused by a mutation in the GGT1 gene which codes for gamma-glutamyltranspeptidase 1. A deficiency in this enzyme results in accumulation of L-cysteine, gamma-glutam...
Enzymes: Glutathione S-transferase omega-2Glutathione Synthetase Deficiency
smpdb.ca/view/SMP0000337DiseaseGlutathione Synthetase Deficiency (5-Oxoprolinuria; Pyroglutamic Aciduria; GSD) is a rare inborn error of metabolism (IEM) which arises from a disfunctional gene called GSS. This gene is responsible for glutathione synthetase. Glutathion...
Enzymes: Glutathione S-transferase omega-25-Oxoprolinuria
smpdb.ca/view/SMP0125615Disease5-Oxoprolinuria (5-Oxoprolinase deficiency) is a result of a defect in the gamma-glutamyl cycle due to either 5-oxoprolinase or glutathione synthetase deficiency. In the case of glutathione synthetase deficiency, the glycine is not incor...
Enzymes: Glutathione S-transferase omega-2gamma-Glutamyltranspeptidase Deficiency
smpdb.ca/view/SMP0125618DiseaseGamma-glutamyltranspeptidase deficiency, characterized by glutathionemia and glutathionuria, is an autosomal recessive disorder of glutathione metabolism caused by a defective gamma-glutamyl transpeptidase (GGT). GGT transfers glutamyl m...
Enzymes: Glutathione S-transferase omega-2Metformin
go.drugbank.com/drugs/DB00331ApprovedInvestigationalIt is commonly described as an "insulin sensitizer", leading to a decrease in insulin resistance and a clinically significant reduction of plasma fasting insulin levels. … Metformin is a biguanide antihyperglycemic agent and first-line pharmacotherapy used in the management of type II diabetes.
Mixtures: AMARYL® M SR, AMARYL® M SRCategories: MATE 1 Substrates, MATE 2 SubstratesCarboprost tromethamine Action Pathway
smpdb.ca/view/SMP0127007Drug actionCarboprost tromethamine is a medication primarily used in obstetrics and gynecology for two distinct purposes. First, it is employed as an abortifacient agent in the second trimester of pregnancy, typically between the 13th and 20th week...
Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1Alprostadil Action Pathway
smpdb.ca/view/SMP0127008Drug actionAlprostadil is a medication used for two distinct purposes. First, it is employed in the treatment of erectile dysfunction in men for whom oral treatment is either contraindicated or ineffective. It can be administered either through an ...
Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1