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Ephrin type-A receptor 3
go.drugbank.com/bio_entities/BE0009437TargetHumansHighly promiscuous for ephrin-A ligands it binds preferentially EFNA5 (By similarity). … Also activated by EFNA1, inhibiting epithelial-to-mesenchymal transition of cardiac cells and playing a role in heart development (PubMed:12794130). Involved in the retinotectal mapping of neurons.
Polypeptides: Ephrin type-A receptor 3Ephrin type-A receptor 6
go.drugbank.com/bio_entities/BE0009439TargetHumansReceptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells.
Polypeptides: Ephrin type-A receptor 6ATP-dependent RNA helicase A
go.drugbank.com/bio_entities/BE0014303TargetHumansPlays a role as a transcriptional coactivator acting as a bridging factor between polymerase II holoenzyme and transcription factors or cofactors, such as BRCA1, CREBBP, RELA and SMN1 (PubMed:11038348, … Plays a role in mRNA translation (PubMed:28355180).
Polypeptides: ATP-dependent RNA helicase ASynonyms: RNA helicase ADocusate
go.drugbank.com/drugs/DB11089ApprovedDocusate, or dioctyl sulfosuccinate, is a stool softener indicated for the treatment of constipation[A32201]. … Additionally, it does not appear to lessen symptoms associated with constipation such as abdominal cramps. Still docusate is available in over-the-counter products as a common laxative.
Mixtures: EX-lax Light Formula Lax W Stool Soften Tab, Natalvirt CaProducts: Lax-A Soft, Non-Habit Forming Stool SoftenerAcetyl-coenzyme A synthetase, cytoplasmic
go.drugbank.com/bio_entities/BE0000350TargetEnzymeHumansCan also utilize propionate with a much lower affinity (PubMed:38369012). Catalyzes the conversion of lactate into lactoyl-CoA (PubMed:39561764). … Acts as a chromatin-bound transcriptional coactivator that up-regulates histone acetylation and expression of neuronal genes (By similarity).
Polypeptides: Acetyl-coenzyme A synthetase, cytoplasmicHydroxyacyl-coenzyme A dehydrogenase, mitochondrial
go.drugbank.com/bio_entities/BE0000377TargetHumansPlays a role in the maintenance of normal spermatogenesis through the reduction of fatty acid accumulation in the testes (By similarity) … Plays a role in the control of insulin secretion by inhibiting the activation of glutamate dehydrogenase 1 (GLUD1), an enzyme that has an important role in regulating amino acid-induced insulin secretion
Polypeptides: Hydroxyacyl-coenzyme A dehydrogenase, mitochondrialSynonyms: Medium and short-chain L-3-hydroxyacyl-coenzyme A dehydrogenaseEphrin type-A receptor 2
go.drugbank.com/bio_entities/BE0000841TargetHumansWith ephrin-A2/EFNA2 may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis … May also participate in UV radiation-induced apoptosis and have a ligand-independent stimulatory effect on chemotactic cell migration.
Polypeptides: Ephrin type-A receptor 2Ribose-5-phosphate isomerase A
go.drugbank.com/bio_entities/BE0001557TargetThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
Polypeptides: Ribose-5-phosphate isomerase ASynonyms: Phosphoriboisomerase AInositol-trisphosphate 3-kinase A
go.drugbank.com/bio_entities/BE0001627TargetHumansCatalyzes the phosphorylation of 1D-myo-inositol 1,4,5-trisphosphate (InsP3) into 1D-myo-inositol 1,3,4,5-tetrakisphosphate and participates to the regulation of calcium homeostasis
Polypeptides: Inositol-trisphosphate 3-kinase ASynonyms: IP3K A, IP3 3-kinase A