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Cyclophosphamide Action Pathway
smpdb.ca/view/SMP0000447Drug actionCyclophosphamide is an alkylating agent used in the treatment of certain cancers. Following absorption, cyclophosphamide is converted into 4-hydroxyphosphamide by a variety of cytochrome P450 isozymes in the liver. 4-Hydroxyphosphamide i...
Enzymes: Glutathione S-transferase Mu 1Methohexital
go.drugbank.com/drugs/DB00474ApprovedAn intravenous anesthetic with a short duration of action that may be used for induction of anesthesia.
Synonyms: (±)-5-allyl-1-methyl-5-(1-methyl-2-pentynyl)barbituric acid, 5-Allyl-5-(3-hexyn-2-yl)-1-methylbarbituric acidCategories: Heterocyclic Compounds, 1-RingTalbutal
go.drugbank.com/drugs/DB00306ApprovedIllicitTalbutal, also called 5-allyl-5-sec-butylbarbituric acid, is a barbiturate with a short to intermediate duration of action. Talbutal is a schedule III drug in the U.S.
Categories: Heterocyclic Compounds, 1-RingSynonyms: (RS)-5-allyl-5-sec-butylpyrimidine-2,4,6(1H,3H,5H)-trione, 5-allyl-5-sec-butylbarbituric acidArsenate Detoxification
smpdb.ca/view/SMP0121123MetabolicFrom here, it forms methylarsonite via the glutathione S-transferase omega-1 enzyme again. … The methylarsonite reacts with S-adenosylmethionine, catalyzed by arsenite methyltransferase, in order to become dimethylarsinate.
Enzymes: Glutathione S-transferase omega-1Gq Serotonergic Smooth Muscle Contraction
smpdb.ca/view/SMP0126954PhysiologicalAlthough numerous GPCRs have the ability to couple to more than one heterotrimeric G protein, a given GPCR is typically classified based on the G protein subfamily (e.g., Gs, Gi/o, or Gq/11) it preferentially activates. Signaling via Gq-...
Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2Lysophosphatidic Acid LPA6 Signalling
smpdb.ca/view/SMP0063759SignalingThe Gα12/13 subunit regulates cell motility and cytoskeletal remodelling by activating the Rho/ROCK and Rho/SRF pathways.
Enzymes: Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLasMuscular Gs Protein Cascade
smpdb.ca/view/SMP0126976PhysiologicalG proteins regulate metabolic enzymes, ion channels, transporter proteins, and other parts of the cell machinery, controlling transcription, motility, contractility, and secretion, which in turn regulate
Enzymes: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1Thioguanine Action Pathway
smpdb.ca/view/SMP0122727Drug actionThioguanine is an antineoplastic compound used to treat acute leukemia. It is usually administered orally and delivered to the site of action through the blood. Thioguanine has similar properties to 6-mercaptopurine as they share similar...
Drugs: Ademetionine · ATP · Tioguanine · Magnesium cation · 5-O-phosphono-alpha-D-ribofuranosyl diphosphate · Pyrophosphoric acidEnzymes: Thiopurine S-methyltransferaseDipivefrin
go.drugbank.com/drugs/DB00449ApprovedWithdrawnDipivefrin is a prodrug of adrenaline, which is used to treat glaucoma. It is available as ophthalmic solution (eye drops).
Synonyms: 1-(3',4'-dipivaloyloxyphenyl)-2-methylamino-1-ethanol, (±)-4-[1-hydroxy-2-(methylamino)ethyl]-o-phenylene divavalateInternational brands: D EpifrinTreprostinil Action Pathway
smpdb.ca/view/SMP0126517Drug actionTreprostinil is a stable tricyclic analogue of prostacyclin, it promotes vasodilation and inhibition of platelet aggregation. Treprostinil is administered either subcutaneously, orally or through inhalation used to treat pulmonary arteri...
Drugs: Treprostinil · Potassium cation · Calcium · Magnesium cation · Cyclic adenosine monophosphateEnzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1