Search
Acetylcholine receptor subunit beta-type lev-1
go.drugbank.com/bio_entities/BE0004927TargetCaenorhabditis elegansNon-alpha subunit of nicotinic acetylcholine receptor (nAChR). Involved in nAChR sensitivity to nicotine.
Polypeptides: Acetylcholine receptor subunit beta-type lev-1Calcitonin gene-related peptide type 1 receptor
go.drugbank.com/bio_entities/BE0009009TargetHumansLigand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. … G protein-coupled receptor which specificity is determined by its interaction with receptor-activity-modifying proteins (RAMPs) (PubMed:32296767, PubMed:33602864, PubMed:8626685).
Polypeptides: Calcitonin gene-related peptide type 1 receptorSynonyms: Calcitonin receptor-like receptor, CGRP type 1 receptorReceptor-interacting serine/threonine-protein kinase 1
go.drugbank.com/bio_entities/BE0009531TargetHumansInhibits RIPK3-mediated necroptosis via FADD-mediated recruitment of CASP8, which cleaves RIPK1 and limits TNF-induced necroptosis (PubMed:19524512, PubMed:19524513, PubMed:29440439, PubMed:30988283).
Polypeptides: Receptor-interacting serine/threonine-protein kinase 1Synonyms: Receptor-interacting protein 1Receptor-interacting serine/threonine-protein kinase 4
go.drugbank.com/bio_entities/BE0009533TargetHumansRequired for embryonic skin development and correct skin homeostasis in adults, via phosphorylation of PKP1 and subsequent promotion of keratinocyte differentiation and cell adhesion (By similarity).
Polypeptides: Receptor-interacting serine/threonine-protein kinase 4Synonyms: Ankyrin repeat domain-containing protein 3Tyrosine-protein phosphatase non-receptor type 12
go.drugbank.com/bio_entities/BE0009940TargetHumansDephosphorylates cellular tyrosine kinases, such as ERBB2 and PTK2B/PYK2, and thereby regulates signaling via ERBB2 and PTK2B/PYK2 (PubMed:17329398, PubMed:27134172).
Polypeptides: Tyrosine-protein phosphatase non-receptor type 12Tumor necrosis factor receptor superfamily member 6
go.drugbank.com/bio_entities/BE0010463TargetHumansReceptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase CASP8 to the activated receptor.
Polypeptides: Tumor necrosis factor receptor superfamily member 6Synonyms: FASLG receptorTumor necrosis factor receptor superfamily member 4
go.drugbank.com/bio_entities/BE0010535TargetHumansReceptor for TNFSF4/OX40L/GP34. Is a costimulatory molecule implicated in long-term T-cell immunity
Polypeptides: Tumor necrosis factor receptor superfamily member 4Synonyms: OX40L receptor, TAX transcriptionally-activated glycoprotein 1 receptorTumor necrosis factor receptor superfamily member 10A
go.drugbank.com/bio_entities/BE0010564TargetHumansReceptor for the cytotoxic ligand TNFSF10/TRAIL (PubMed:26457518, PubMed:38532423). The adapter molecule FADD recruits caspase-8 to the activated receptor.
Polypeptides: Tumor necrosis factor receptor superfamily member 10ASynonyms: Death receptor 4, TRAIL receptor 1Inactive tyrosine-protein kinase transmembrane receptor ROR1
go.drugbank.com/bio_entities/BE0010828TargetHumansVia IGFBP5 ligand, forms a complex with ERBB2 to enhance CREB oncogenic signaling (PubMed:36949068) … Receptor for ligand WNT5A which activates downstream NFkB signaling pathway and may result in the inhibition of WNT3A-mediated signaling (PubMed:25029443, PubMed:27162350).
Polypeptides: Inactive tyrosine-protein kinase transmembrane receptor ROR1Synonyms: Neurotrophic tyrosine kinase, receptor-related 1Macrophage scavenger receptor types I and II
go.drugbank.com/bio_entities/BE0010942TargetHumansMembrane receptor that mediates the binding, endocytosis and phagocytosis of a broad range of ligands.
Polypeptides: Macrophage scavenger receptor types I and IISynonyms: Scavenger receptor class A member 1, Macrophage acetylated LDL receptor I and II