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Tyrosine-protein phosphatase non-receptor type 6
go.drugbank.com/bio_entities/BE0009941TargetHumansModulates the signaling of several cytokine receptors including IL-4 receptor (PubMed:9065461). … Dephosphorylates and negatively regulate several receptor tyrosine kinases (RTKs) such as EGFR, PDGFR and FGFR, thereby modulating their signaling activities (PubMed:21258366, PubMed:9733788).
Polypeptides: Tyrosine-protein phosphatase non-receptor type 6Tumor necrosis factor receptor superfamily member 17
go.drugbank.com/bio_entities/BE0010010TargetHumansReceptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK
Polypeptides: Tumor necrosis factor receptor superfamily member 17Function: signaling receptor activityC-X-C chemokine receptor type 2
go.drugbank.com/bio_entities/BE0010516TargetHumansReceptor for interleukin-8 which is a powerful neutrophil chemotactic factor (PubMed:1891716). Binding of IL-8 to the receptor causes activation of neutrophils.
Polypeptides: C-X-C chemokine receptor type 2Synonyms: GRO/MGSA receptor, IL-8 receptor type 2Tumor necrosis factor receptor superfamily member 16
go.drugbank.com/bio_entities/BE0010540TargetHumansLow affinity receptor which can bind to NGF, BDNF, NTF3, and NTF4. … Forms a heterodimeric receptor with SORCS2 that binds the precursor forms of NGF, BDNF and NTF3 with high affinity, and has much lower affinity for mature NGF and BDNF (PubMed:24908487).
Polypeptides: Tumor necrosis factor receptor superfamily member 16Synonyms: NGF receptor, Low affinity neurotrophin receptor p75NTRAntiviral innate immune response receptor RIG-I
go.drugbank.com/bio_entities/BE0012418TargetHumansInnate immune receptor that senses cytoplasmic viral nucleic acids and activates a downstream signaling cascade leading to the production of type I interferons and pro-inflammatory cytokines (PubMed:15208624
Polypeptides: Antiviral innate immune response receptor RIG-ISynonyms: RIG-I-like receptor 1Tumor necrosis factor receptor superfamily member 13C
go.drugbank.com/bio_entities/BE0018598TargetHumansB-cell receptor specific for TNFSF13B/TALL1/BAFF/BLyS. Promotes the survival of mature B-cells and the B-cell response
Polypeptides: Tumor necrosis factor receptor superfamily member 13CSynonyms: BAFF receptor, BLyS receptor 3Tumor necrosis factor receptor superfamily member 12A
go.drugbank.com/bio_entities/BE0020009TargetHumansReceptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins
Polypeptides: Tumor necrosis factor receptor superfamily member 12ASynonyms: Tweak-receptorAcetylcholine receptor subunit alpha-type acr-16
go.drugbank.com/bio_entities/BE0027703TargetCaenorhabditis elegansA subunit of the levamisole-insensitive nicotinic receptor.
Polypeptides: Acetylcholine receptor subunit alpha-type acr-16Iodine
go.drugbank.com/drugs/DB05382ApprovedInvestigationalIodine is commonly used as an antiseptic for minor cuts and abrasions, preventing infections that may result from contaminated wounds. Additionally, iodine has been studied in the treatment of fibrocystic disease and breast cancer.
Mixtures: Revit Multi-vitamins and MineralsMitomycin
go.drugbank.com/drugs/DB00305ApprovedInvestigational[A193419] Mitomycin's cross-linking activity has resulted in its approval for the treatment of a variety of cancers - the most recent of which is an April 2020 approval for its use in low-grade Upper