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Displaying results 941 - 950 of 10000 in total
  1. Target

    Thioesterase 1/protease 1/lysophospholipase L1

    go.drugbank.com/bio_entities/BE0002014
    TargetEscherichia coli (strain K12)

    TesA is a multifunctional esterase that can act as a thioesterase, lysophospholipase and protease (PubMed:10423542, PubMed:1864840, PubMed:238979, PubMed:4554913, PubMed:4945109, PubMed:791643, PubMed:

    Synonyms: Thioesterase I/protease I, TEP-I
  2. Drug

    Dioxybenzone

    go.drugbank.com/drugs/DB11221
    ApprovedWithdrawn

    Dioxybenzone is an approved sunscreen ingredient in concentrations up to 3% [L2525]. … Dioxybenzone, or benzophenone-8, is an organic compound derived from [DB01878] that is used as a sunscreen agent. It absorbed UV-B and UV-AII rays.

    Synonyms: 2,2'-Dihydroxy-4-methoxybenzophenone
  3. Drug

    Phenelzine

    go.drugbank.com/drugs/DB00780
    ApprovedInvestigational

    [A15753] It was developed by Parke Davis and originally FDA approved on June 9th, 1961. It is currently approved under prescription by the name of Nardil. … Phenelzine, with the formula β-phenylethylhydrazine, is a monoamine oxidase inhibiting antidepressant that is effective in the treatment of panic disorder and social anxiety disorder.

    Categories: Monoamine Oxidase Inhibitors, Non-Selective, Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome
  4. Drug

    Lofexidine

    go.drugbank.com/drugs/DB04948
    ApprovedInvestigational

    [T209] Lofexidine was developed by US Woldmeds LLC and it was approved by the FDA on May 16, 2018.[L2794] … [A33084] It was first studied for use as an antihypertensive in 1980, but its researched was stopped as it was found less effective for the treatment of hypertension than clonidine.

    Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome, Drugs Used in Opioid DependenceSynonyms: 2-(alpha-(2,6-Dichlorophenoxy)ethyl)2-imidazoline
  5. Target

    Dynamin-1

    go.drugbank.com/bio_entities/BE0013996
    TargetHumans

    Depending on the curvature imposed on the tubules, membrane detachment from the helical polymer upon GTP hydrolysis can cause spontaneous hemifission followed by complete fission (PubMed:19084269). … Mediates rapid endocytosis (RE), a Ca(2+)-dependent and clathrin- and K(+)-independent process in chromaffin cells (By similarity).

    Synonyms: Dynamin I
  6. Drug

    Technetium Tc-99m nofetumomab merpentan

    go.drugbank.com/drugs/DB09336
    ApprovedWithdrawn

    It was after discontinued on August 13, 2013, but in the 2018 FDA submission list, it can be found as a substance type II (Drug substance) with an active status.[L1650, L1082] … [FDA label] Tc-99m nm was developed by Boehringer Ingelheim Pharma KG and FDA approved on September 14, 1992.

  7. Drug

    Montelukast

    go.drugbank.com/drugs/DB00471
    ApprovedInvestigational

    Montelukast was first approved for clinical use by the US FDA in 1998 as Merck's brand name Singulair. … worldwide via millions of prescriptions annually and has since become available as a generic and as a brand name product.

    Mixtures: BROCRIPTIN® 10 MG/ 5 MG, GLEMONT L® TABLETAS RECUBIERTASCategories: Agents to Treat Airway Disease, Cytochrome P-450 Substrates
  8. Drug

    Mepyramine

    go.drugbank.com/drugs/DB06691
    ApprovedVet approved

    It has been found in over-the-counter combination products for colds and menstrual symptoms, but is considered to be an unapproved prescription medication used for cough, cold, or allergic conditions. … It is a first generation antihistamine. However, it rapidly permeates the brain and so often causes drowsiness as a side effect.

    Synonyms: N-(p-methoxybenzyl)-N',N'-dimethyl-N-(α-pyridyl)ethylenediamine, N',N'-dimethyl-N-(p-methoxybenzyl)-N-(2-pyridyl)ethylenediamineMixtures: I D M Expectorant Tab, K-FENIDEX JEL 30 G
  9. Drug

    Sodium acetate

    go.drugbank.com/drugs/DB09395
    ApprovedInvestigational

    It can be used also in metabolic acidosis and for urine alkalinization. … Medically, sodium acetate is important component as an electrolyte replenisher when given intravenously. It is mainly indicated to correct sodium levels in hyponatremic patients.

    Synonyms: Acetic acid, sodium salt (1:1)Mixtures: INYECCION MULTIPLE DE ELECTROLITOS TIPO I, OLICLINOMEL N4-550 E EMULSION FOR INFUSION
  10. Target

    Lactoylglutathione lyase

    go.drugbank.com/bio_entities/BE0000962
    TargetEnzymeHumans

    Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione (PubMed:20454679, PubMed:23122816, PubMed:9705294). Involved in the regulation of TNF-induced transcriptional activity of NF-ka...

    Synonyms: Glx I, Glyoxalase I