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BDNF/NT-3 growth factors receptor
go.drugbank.com/bio_entities/BE0003605TargetHumansReceptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4. … Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2 (PubMed:15494731, PubMed:7574684).
Polypeptides: BDNF/NT-3 growth factors receptorSynonyms: Neurotrophic tyrosine kinase receptor type 2Receptor-type tyrosine-protein phosphatase beta
go.drugbank.com/bio_entities/BE0003769TargetHumansPlays an important role in blood vessel remodeling and angiogenesis. Not necessary for the initial formation of blood vessels, but is essential for their maintenance and remodeling. Can induce dephosphorylation of TEK/TIE2, CDH5/VE-cadhe...
Polypeptides: Receptor-type tyrosine-protein phosphatase betaT cell receptor beta constant 1
go.drugbank.com/bio_entities/BE0003779TargetHumansConstant region of T cell receptor (TR) beta chain (PubMed:24600447).
Polypeptides: T cell receptor beta constant 1Cation-dependent mannose-6-phosphate receptor
go.drugbank.com/bio_entities/BE0004494TargetTransporterHumansLysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal
Polypeptides: Cation-dependent mannose-6-phosphate receptorSynonyms: CD Man-6-P receptor, 46 kDa mannose 6-phosphate receptorReceptor tyrosine-protein kinase erbB-4
go.drugbank.com/bio_entities/BE0004772TargetHumansActs as cell-surface receptor for the neuregulins NRG1, NRG2, NRG3 and NRG4 and the EGF family members BTC, EREG and HBEGF. … Ligand binding triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors.
Polypeptides: Receptor tyrosine-protein kinase erbB-4Synonyms: Tyrosine kinase-type cell surface receptor HER4Membrane-associated progesterone receptor component 1
go.drugbank.com/bio_entities/BE0004896TargetHumansForms a ternary complex with TMEM97 receptor and low density lipid receptor/LDLR, which increases LDLR-mediated LDL lipoprotein internalization (PubMed:30443021)
Polypeptides: Membrane-associated progesterone receptor component 1GABA(A) Receptor Benzodiazepine Binding Site
go.drugbank.com/bio_entities/BE0008668TargetHumansGABAARs function also as histamine receptor where histamine binds at the interface of two neighboring beta subunits and potentiates GABA response (By similarity). … GABAARs function also as histamine receptor where histamine binds at the interface of two neighboring beta subunits and potentiates GABA response in a gamma-2 subunit-controlled manner (By similarity)
Polypeptides: Gamma-aminobutyric acid receptor subunit alpha-1, Gamma-aminobutyric acid receptor subunit alpha-2Synonyms: GABA(A) receptor subunit alpha-1, GABA(A) receptor subunit alpha-2Taste receptor type 2 member 16
go.drugbank.com/bio_entities/BE0009016TargetHumansGustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5
Polypeptides: Taste receptor type 2 member 16Function: bitter taste receptor activityBone morphogenetic protein receptor type-1A
go.drugbank.com/bio_entities/BE0009272TargetHumansOn ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. … Receptor for BMP2, BMP4, GDF5 and GDF6. Positively regulates chondrocyte differentiation through GDF5 interaction. Mediates induction of adipogenesis by GDF6.
Polypeptides: Bone morphogenetic protein receptor type-1ASynonyms: BMP type-1A receptor, Activin receptor-like kinase 3Bone morphogenetic protein receptor type-2
go.drugbank.com/bio_entities/BE0009324TargetHumansOn ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases.
Polypeptides: Bone morphogenetic protein receptor type-2Synonyms: BMP type II receptor, BMP type-2 receptor