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Epoprostenol Action Pathway
smpdb.ca/view/SMP0126492Drug actionEpoprostenol is a platelet aggregator inhibitor also known under the brand name of Flolan and Veletri, used to manage hypertension in patients with heart failure. It is synthesized from prostaglandin endoperoxides in human vascular tissu...
Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1Lafutidine H2 Anti-Histamine Action Pathway
smpdb.ca/view/SMP0051038Drug actionLafutidine (also known as INN) is a second generation histamine H2 receptor antagonist that can be used for treating ulcers and reflux. Inhibition of histamine H2 receptor can inhibit histamine-stimulated gastric acid secretion which wil...
Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12, Guanine nucleotide-binding protein G(s) subunit alpha isoforms shortMetipranolol
go.drugbank.com/drugs/DB01214ApprovedWithdrawnA beta-adrenergic antagonist effective for both beta-1 and beta-2 receptors. It is used as an antiarrhythmic, antihypertensive, and antiglaucoma agent.
Synonyms: Acetic acid 4-(2-hydroxy-3-isopropylamino-propoxy)-2,3,6-trimethyl-phenyl esterCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2D6 SubstratesGi Muscarinic Cardiac Muscle Contraction
smpdb.ca/view/SMP0126951PhysiologicalThe M2 muscarinic receptors are located in the heart, where they act to slow the heart rate down to normal sinus rhythm after negative stimulatory actions of the parasympathetic nervous system, by slowing the speed of depolarization. The...
Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1Cyclophosphamide Action Pathway
smpdb.ca/view/SMP0000447Drug actionCyclophosphamide is an alkylating agent used in the treatment of certain cancers. Following absorption, cyclophosphamide is converted into 4-hydroxyphosphamide by a variety of cytochrome P450 isozymes in the liver. 4-Hydroxyphosphamide i...
Enzymes: Glutathione S-transferase Mu 1Methohexital
go.drugbank.com/drugs/DB00474ApprovedAn intravenous anesthetic with a short duration of action that may be used for induction of anesthesia.
Synonyms: (±)-5-allyl-1-methyl-5-(1-methyl-2-pentynyl)barbituric acid, 5-Allyl-5-(3-hexyn-2-yl)-1-methylbarbituric acidCategories: Heterocyclic Compounds, 1-RingTalbutal
go.drugbank.com/drugs/DB00306ApprovedIllicitTalbutal, also called 5-allyl-5-sec-butylbarbituric acid, is a barbiturate with a short to intermediate duration of action. Talbutal is a schedule III drug in the U.S.
Synonyms: (RS)-5-allyl-5-sec-butylpyrimidine-2,4,6(1H,3H,5H)-trione, 5-allyl-5-sec-butylbarbituric acidCategories: Heterocyclic Compounds, 1-RingArsenate Detoxification
smpdb.ca/view/SMP0121123MetabolicFrom here, it forms methylarsonite via the glutathione S-transferase omega-1 enzyme again. … The methylarsonite reacts with S-adenosylmethionine, catalyzed by arsenite methyltransferase, in order to become dimethylarsinate.
Enzymes: Glutathione S-transferase omega-1Gq Serotonergic Smooth Muscle Contraction
smpdb.ca/view/SMP0126954PhysiologicalAlthough numerous GPCRs have the ability to couple to more than one heterotrimeric G protein, a given GPCR is typically classified based on the G protein subfamily (e.g., Gs, Gi/o, or Gq/11) it preferentially activates. Signaling via Gq-...
Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2Carmustine
go.drugbank.com/drugs/DB00262ApprovedInvestigational(From Merck Index, 11th ed) … A cell-cycle phase nonspecific alkylating antineoplastic agent. It is used in the treatment of brain tumors and various other malignant neoplasms.
Synonyms: N,N'-Bis(2-chloroethyl)-N-nitrosoureaCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 Substrates