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Displaying results 9521 - 9530 of 10000 in total
  1. Pathway

    Cardiolipin Biosynthesis CL(22:5(4Z,7Z,10Z,13Z,16Z)/22:5(7Z,10Z,13Z,16Z,19Z)/18:2(9Z,12Z)/20:4(5Z,8Z,11Z,14Z))

    smpdb.ca/view/SMP0255245
    Metabolic

    Third, the enzyme 1-acyl-sn-glycerol-3-phosphate acyltransferase converts LPA into phosphatidic acid (PA or 1,2-diacyl-sn-glycerol 3-phosphate) by esterifying an acyl-group to the sn-2 position of the

    Drugs: NADH · Cytidine-5'-Triphosphate · sn-glycerol 3-phosphate · Pyrophosphoric acid · Dihydroxyacetone phosphate
    Enzymes: Phosphatidate cytidylyltransferase 2
  2. Pathway

    Cardiolipin Biosynthesis CL(22:5(7Z,10Z,13Z,16Z,19Z)/22:5(7Z,10Z,13Z,16Z,19Z)/18:2(9Z,12Z)/20:4(5Z,8Z,11Z,14Z))

    smpdb.ca/view/SMP0255421
    Metabolic

    Third, the enzyme 1-acyl-sn-glycerol-3-phosphate acyltransferase converts LPA into phosphatidic acid (PA or 1,2-diacyl-sn-glycerol 3-phosphate) by esterifying an acyl-group to the sn-2 position of the

    Drugs: NADH · Cytidine-5'-Triphosphate · sn-glycerol 3-phosphate · Pyrophosphoric acid · Dihydroxyacetone phosphate
    Enzymes: Phosphatidate cytidylyltransferase 2
  3. Drug

    Eptinezumab

    go.drugbank.com/drugs/DB14040
    ApprovedInvestigational

    Eptinezumab is a fully-humanized IgG1 antibody manufactured using yeast (_Pichia pastoris_) and developed by Lundbeck Seattle Biopharmaceuticals.

    Products: Vyepti® 100 mg/mL concentrate for solution for infusion, VYEPTI CONCENTRATE FOR SOLUTION FOR INFUSION 100MG/ML
  4. Target

    17-beta-hydroxysteroid dehydrogenase type 2

    go.drugbank.com/bio_entities/BE0000006
    TargetEnzymeHumans

    Catalyzes the NAD-dependent oxidation of the highly active 17beta-hydroxysteroids, such as estradiol (E2), testosterone (T), and dihydrotestosterone (DHT), to their less active forms and thus regulates the biological potency of these ste...

    Polypeptides: 17-beta-hydroxysteroid dehydrogenase type 2Synonyms: 17-beta-HSD 2, Estradiol 17-beta-dehydrogenase 2
  5. Target

    11-beta-hydroxysteroid dehydrogenase type 2

    go.drugbank.com/bio_entities/BE0000131
    TargetEnzymeHumans

    hydroxycholesterol in vitro (PubMed:30902677). 7-beta-25-dihydroxycholesterol (not 7-oxo-25-hydroxycholesterol) acts as a ligand for the G protein-coupled receptor (GPCR) Epstein-Barr virus-induced gene 2

    Polypeptides: 11-beta-hydroxysteroid dehydrogenase type 2Synonyms: Corticosteroid 11-beta-dehydrogenase isozyme 2
  6. Target

    3-hydroxyacyl-CoA dehydrogenase type-2

    go.drugbank.com/bio_entities/BE0000317
    TargetEnzymeHumans

    Catalyzes the oxidation of 3-hydroxy-2-methylbutanoyl-CoA into 2-methyl-3-oxobutanoyl-CoA, a step in isoleucine degradation pathway (PubMed:18996107, PubMed:19706438, PubMed:20077426). … Acts as 3-hydroxy-2-methylbutyryl-CoA dehydrogenase in branched-chain amino acid catabolic pathway.

    Polypeptides: 3-hydroxyacyl-CoA dehydrogenase type-2Synonyms: Mitochondrial RNase P protein 2, 2-methyl-3-hydroxybutyryl-CoA dehydrogenase
  7. Target

    G protein-coupled receptor kinase 2

    go.drugbank.com/bio_entities/BE0000341
    TargetHumans

    Specifically phosphorylates the activated forms of G protein-coupled receptors (PubMed:14976224, PubMed:16179383, PubMed:19306925, PubMed:19715378, PubMed:21799898, PubMed:23077507, PubMed:30284927, PubMed:33859231, PubMed:39138140, PubM...

    Polypeptides: G protein-coupled receptor kinase 2
  8. Target

    Solute carrier family 13 member 2

    go.drugbank.com/bio_entities/BE0000447
    TransporterHumans

    Low-affinity sodium-dicarboxylate cotransporter, that mediates the entry of citric acid cycle intermediates, such as succinate, citrate, fumarate and alpha-ketoglutarate (2-oxoglutarate) into the small

    Polypeptides: Solute carrier family 13 member 2
  9. Target

    Receptor tyrosine-protein kinase erbB-2

    go.drugbank.com/bio_entities/BE0000511
    TargetEnzymeHumans

    Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with i...

    Polypeptides: Receptor tyrosine-protein kinase erbB-2Synonyms: Proto-oncogene c-ErbB-2
  10. Target

    Growth factor receptor-bound protein 2

    go.drugbank.com/bio_entities/BE0000917
    TargetHumans

    Functions also a role in B-cell activation by amplifying Ca(2+) mobilization and activation of the ERK MAP kinase pathway upon recruitment to the phosphorylated B-cell antigen receptor (BCR) (PubMed:25413232

    Polypeptides: Growth factor receptor-bound protein 2