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Displaying results 951 - 960 of 6949 in total
  1. Target

    Thyroid hormone receptor beta

    go.drugbank.com/bio_entities/BE0000315
    TargetHumans

    Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine

    Polypeptides: Thyroid hormone receptor betaSynonyms: Nuclear receptor subfamily 1 group A member 2
  2. Target

    Follicle-stimulating hormone receptor

    go.drugbank.com/bio_entities/BE0000387
    TargetHumans

    G protein-coupled receptor for follitropin, the follicle-stimulating hormone (PubMed:11847099, PubMed:24058690, PubMed:24692546). … Also affects hepatic cholesterol metabolism by increasing serum total and low-density-lipoprotein cholesterol (LDL-C) by inhibiting the expression of LDL receptor (LDLR) (PubMed:26583582)

    Polypeptides: Follicle-stimulating hormone receptorSynonyms: Follitropin receptor
  3. Target

    Muscarinic acetylcholine receptor M4

    go.drugbank.com/bio_entities/BE0000405
    TargetHumans

    The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action

    Polypeptides: Muscarinic acetylcholine receptor M4Function: G protein-coupled acetylcholine receptor activity
  4. Target

    Delta-type opioid receptor

    go.drugbank.com/bio_entities/BE0000420
    TargetHumans

    G protein-coupled receptor that functions as a receptor for endogenous enkephalins and for a subset of other opioids.

    Polypeptides: Delta-type opioid receptorFunction: G protein-coupled enkephalin receptor activity
  5. Target

    5-hydroxytryptamine receptor 2A

    go.drugbank.com/bio_entities/BE0000451
    TargetHumans

    G protein-coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:1330647, PubMed:18703043, PubMed:19057895, PubMed:21645528, PubMed:22300836, PubMed:35084960, PubMed:38552625). … Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD) (PubMed

    Polypeptides: 5-hydroxytryptamine receptor 2ASynonyms: Serotonin receptor 2A
  6. Target

    Neurotensin receptor type 2

    go.drugbank.com/bio_entities/BE0000464
    TargetHumans

    Receptor for the tridecapeptide neurotensin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system

    Polypeptides: Neurotensin receptor type 2Synonyms: Levocabastine-sensitive neurotensin receptor
  7. Target

    Melatonin receptor type 1A

    go.drugbank.com/bio_entities/BE0000515
    TargetHumans

    High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. … The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.

    Polypeptides: Melatonin receptor type 1ASynonyms: Mel1a receptor
  8. Target

    Muscarinic acetylcholine receptor M2

    go.drugbank.com/bio_entities/BE0000560
    TargetHumans

    Muscarinic receptor for acetylcholine, a neurotransmitter found in the brain, neuromuscular junctions and the autonomic ganglia (PubMed:24256733, PubMed:3443095, PubMed:36690613).

    Polypeptides: Muscarinic acetylcholine receptor M2
  9. Target

    Alpha-2B adrenergic receptor

    go.drugbank.com/bio_entities/BE0000572
    TargetHumans

    Alpha-2 adrenergic receptors are G protein-coupled receptors for catecholamines that activate G(i/o) protein pathway, thereby promoting adenylyl cyclase inhibition, ERK1/2 stimulation, and voltage-gated calcium channels suppression (PubM...

    Polypeptides: Alpha-2B adrenergic receptorSynonyms: Alpha-2 adrenergic receptor subtype C2
  10. Target

    Hydroxycarboxylic acid receptor 2

    go.drugbank.com/bio_entities/BE0000635
    TargetHumans

    Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated … Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis

    Polypeptides: Hydroxycarboxylic acid receptor 2Synonyms: Niacin receptor 1, Nicotinic acid receptor