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Displaying results 961 - 970 of 10000 in total
  1. Target

    Peptidyl-prolyl cis-trans isomerase A

    go.drugbank.com/bio_entities/BE0001014
    TargetHumans

    Inhibits replication of influenza A virus (IAV) (PubMed:19207730). … Exerts a strong chemotactic effect on leukocytes partly through activation of one of its membrane receptors BSG/CD147, initiating a signaling cascade that culminates in MAPK/ERK activation (PubMed:11943775

    Polypeptides: Peptidyl-prolyl cis-trans isomerase ASynonyms: PPIase A, Rotamase A
  2. Target

    Ribosomal small subunit pseudouridine synthase A

    go.drugbank.com/bio_entities/BE0001276
    TargetHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)

    Responsible for synthesis of pseudouridine from uracil-516 in 16S ribosomal RNA.

    Polypeptides: Ribosomal small subunit pseudouridine synthase ASynonyms: rRNA-uridine isomerase A, rRNA pseudouridylate synthase A
  3. Target

    Methane monooxygenase component A alpha chain

    go.drugbank.com/bio_entities/BE0003331
    TargetEnzymeMethylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath)

    It also catalyzes the monohydroxylation of a variety of unactivated alkenes, alicyclic, aromatic and heterocyclic compounds.

    Polypeptides: Methane monooxygenase component A alpha chain
  4. Target

    DNA polymerase epsilon catalytic subunit A

    go.drugbank.com/bio_entities/BE0003614
    TargetHumans

    Along with DNA polymerase POLD1 and DNA polymerase POLK, has a role in excision repair (NER) synthesis following UV irradiation (PubMed:20227374)

    Polypeptides: DNA polymerase epsilon catalytic subunit ASynonyms: DNA polymerase II subunit A
  5. Indication

    Prevention of subtype A viruses contained in the 2015 formula Influenza A Virus Infection

    go.drugbank.com/conditions/DBCOND0112773
    Drugs: Influenza A virus A/Slovenia/2903/2015 (H1N1) live (attenuated) antigen
    Synonyms: Prevention of subtype A viruses contained in the 2015 formula Influenza A Virus Infection
  6. Drug

    Etanercept

    go.drugbank.com/drugs/DB00005
    ApprovedInvestigational

    It is used to treat or manage a variety of inflammatory conditions including rheumatoid arthritis (RA), ankylosing spondylitis (AS), and juvenile idiopathic poly-articular arthritis (JIA). … Etanercept is produced by recombinant DNA technology in a Chinese hamster ovary (CHO) mammalian cell expression system. It consists of 934 amino acids.

    Products: Enbrel Solution for Injection in a Pre-filled Pen 50mg, Enbrel Solution for Injection in a Pre-filled Syringe 50mg
  7. Target

    Methylmalonic aciduria type A protein, mitochondrial

    go.drugbank.com/bio_entities/BE0000320
    TargetHumans

    Plays a dual role as both a protectase and a reactivase for MMUT (PubMed:21138732, PubMed:28943303). … Functions as a G protein chaperone that assists AdoCbl cofactor delivery from MMAB to the methylmalonyl-CoA mutase (MMUT) (PubMed:20876572, PubMed:28497574).

    Polypeptides: Methylmalonic aciduria type A protein, mitochondrial
  8. Target

    Ribosomal small subunit pseudouridine synthase A

    go.drugbank.com/bio_entities/BE0002034
    TargetEscherichia coli (strain K12)

    Responsible for synthesis of pseudouridine from uracil-516 in 16S ribosomal RNA.

    Polypeptides: Ribosomal small subunit pseudouridine synthase ASynonyms: rRNA-uridine isomerase A, rRNA pseudouridylate synthase A
  9. Target

    Peroxisomal acyl-coenzyme A oxidase 1

    go.drugbank.com/bio_entities/BE0004135
    TargetEnzymeHumans

    May play a role in peroxisomal beta-oxidation step in polyunsaturated fatty acids (PUFAs) biosynthesis. … Catalyzes the desaturation of fatty acyl-CoAs that have a saturated bond between C2 and C3 (2,3-saturated acyl-CoA) to 2-trans-enoyl-CoAs ((2E)-enoyl-CoAs), and donates electrons directly to molecular

    Polypeptides: Peroxisomal acyl-coenzyme A oxidase 1
  10. Target

    GABA(A) Receptor Benzodiazepine Binding Site

    go.drugbank.com/bio_entities/BE0008668
    TargetHumans

    GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit … GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit

    Synonyms: GABA(A) receptor subunit alpha-1, GABA(A) receptor subunit alpha-2Function: GABA-A receptor activity, GABA-A receptor activity