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Displaying results 961 - 970 of 10000 in total
  1. Target

    Interleukin-6 receptor subunit beta

    go.drugbank.com/bio_entities/BE0010013
    TargetHumans

    Functions as a shared signal-transducing subunit not only for IL6 but also for other cytokine receptor complexes, including IL6, LIF, OSM, CNTF, IL11, CTF1, BSF3, MT-RNR2/humanin, CLCF1 and the heterodimeric … Binding of cytokines, such as IL6 or IL11 to the alpha-chains of their specific cell surface receptor triggers homodimerization of IL6ST/gp130 (PubMed:19915009, PubMed:2261637, PubMed:23294003, PubMed:

    Polypeptides: Interleukin-6 receptor subunit betaSynonyms: IL-6 receptor subunit beta, Oncostatin-M receptor subunit alpha
  2. Target

    Free fatty acid receptor 2

    go.drugbank.com/bio_entities/BE0010131
    TargetHumans

    Exhibits a SCFA-independent constitutive G protein-coupled receptor activity (PubMed:23066016) … G protein-coupled receptor that is activated by a major product of dietary fiber digestion, the short chain fatty acids (SCFAs), and that plays a role in the regulation of whole-body energy homeostasis

    Polypeptides: Free fatty acid receptor 2Synonyms: G protein-coupled receptor 43
  3. Target

    Uracil nucleotide/cysteinyl leukotriene receptor

    go.drugbank.com/bio_entities/BE0010169
    TargetHumans

    Dual specificity receptor for uracil nucleotides and cysteinyl leukotrienes (CysLTs). Signals through G(i) and inhibition of adenylyl cyclase.

    Polypeptides: Uracil nucleotide/cysteinyl leukotriene receptorSynonyms: P2Y-like receptor, UDP/CysLT receptor
  4. Target

    Platelet-derived growth factor receptor

    go.drugbank.com/bio_entities/BE0010249
    TargetHumans

    Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor … Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor

    Polypeptides: Platelet-derived growth factor receptor alpha, Platelet-derived growth factor receptor betaSynonyms: Alpha platelet-derived growth factor receptor, Platelet-derived growth factor receptor 2
  5. Target

    Aryl hydrocarbon receptor nuclear translocator

    go.drugbank.com/bio_entities/BE0010296
    TargetHumans

    Forms heterodimers with the aryl hydrocarbon receptor (AHR) to mediate the transcriptional response to xenobiotics by binding xenobiotic response elements (XREs) or dioxin response elements (DREs) in target

    Polypeptides: Aryl hydrocarbon receptor nuclear translocatorSynonyms: Dioxin receptor, nuclear translocator
  6. Target

    Interleukin-1 receptor accessory protein

    go.drugbank.com/bio_entities/BE0010488
    TargetHumans

    Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. … The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor. Coreceptor for IL1RL1 in the IL-33 signaling system.

    Polypeptides: Interleukin-1 receptor accessory proteinSynonyms: Interleukin-1 receptor 3, IL-1 receptor accessory protein
  7. Target

    Interleukin-15 receptor subunit alpha

    go.drugbank.com/bio_entities/BE0010620
    TargetHumans

    High-affinity receptor for interleukin-15 (PubMed:8530383). Can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells (By similarity).

    Polypeptides: Interleukin-15 receptor subunit alphaSynonyms: IL-15 receptor subunit alpha
  8. Target

    GDNF family receptor alpha-3

    go.drugbank.com/bio_entities/BE0011826
    TargetHumans

    ARTN-binding leads to autophosphorylation and activation of the RET receptor (PubMed:31535977, PubMed:9883723) … Receptor for artemin (ARTN), a growth factor that supports the survival of sensory and sympathetic peripheral neurons (PubMed:31535977, PubMed:9883723).

    Polypeptides: GDNF family receptor alpha-3Synonyms: GDNF receptor alpha-3
  9. Target

    Vasoactive intestinal polypeptide receptor 2

    go.drugbank.com/bio_entities/BE0013151
    TargetHumans

    G protein-coupled receptor activated by the neuropeptides vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (ADCYAP1/PACAP) (PubMed:7811244, PubMed:35477937, PubMed

    Polypeptides: Vasoactive intestinal polypeptide receptor 2Synonyms: VPAC2 receptor, PACAP type III receptor
  10. Target

    Interleukin-1 receptor-like 1

    go.drugbank.com/bio_entities/BE0013861
    TargetHumans

    Receptor for interleukin-33 (IL-33) which plays crucial roles in innate and adaptive immunity, contributing to tissue homeostasis and responses to environmental stresses together with coreceptor IL1RAP

    Polypeptides: Interleukin-1 receptor-like 1Function: cytokine receptor activity