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G protein-coupled receptor kinase 5
go.drugbank.com/bio_entities/BE0013072TargetHumansSuch receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their down-regulation. … Phosphorylation of ST13 regulates internalization of the chemokine receptor. Phosphorylates rhodopsin (RHO) (in vitro) and a non G protein-coupled receptor, LRP6 during Wnt signaling (in vitro)
Polypeptides: G protein-coupled receptor kinase 5Synonyms: G protein-coupled receptor kinase GRK5Interleukin-12 receptor subunit beta-1
go.drugbank.com/bio_entities/BE0013218TargetHumansFunctions as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12 transduction. Associated with IL12RB2 it forms a functional, high affinity receptor for IL12. … Also associates with IL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade
Polypeptides: Interleukin-12 receptor subunit beta-1Synonyms: IL-12 receptor beta component, IL-12 receptor subunit beta-1Short transient receptor potential channel 1
go.drugbank.com/bio_entities/BE0013282TargetHumansForms a receptor-activated non-selective calcium permeant cation channel (PubMed:11139478, PubMed:15016832, PubMed:39478185).
Polypeptides: Short transient receptor potential channel 1Synonyms: Transient receptor protein 1Interleukin-12 receptor subunit beta-2
go.drugbank.com/bio_entities/BE0018860TargetHumansReceptor for interleukin-12. This subunit is the signaling component coupling to the JAK2/STAT4 pathway. Promotes the proliferation of T-cells as well as NK cells.
Polypeptides: Interleukin-12 receptor subunit beta-2Synonyms: IL-12 receptor subunit beta-2Taste receptor type 2 member 10
go.drugbank.com/bio_entities/BE0020463TargetHumansGustducin-coupled strychnine receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract.
Polypeptides: Taste receptor type 2 member 10Synonyms: Taste receptor family B member 2Short transient receptor potential channel 4
go.drugbank.com/bio_entities/BE0020751TargetHumansForms a receptor-activated non-selective calcium permeant cation channel (PubMed:11042129, PubMed:11713258, PubMed:16144838, PubMed:39478185).
Polypeptides: Short transient receptor potential channel 4Short transient receptor potential channel 5
go.drugbank.com/bio_entities/BE0021113TargetHumansForms a receptor-activated non-selective calcium permeant cation channel (PubMed:16284075, PubMed:38959890, PubMed:37137991).
Polypeptides: Short transient receptor potential channel 5Synonyms: Transient receptor protein 5Taste receptor type 2 member 14
go.drugbank.com/bio_entities/BE0023216TargetHumansGustducin-linked G protein-coupled receptor that plays a role in the perception of bitterness (PubMed:38600377, PubMed:38776963). … The activity of this receptor stimulates GNAT3, activating the gustducin G protein pathway (PubMed:38600377, PubMed:38776963).
Polypeptides: Taste receptor type 2 member 14Synonyms: Taste receptor family B member 1Pitolisant
go.drugbank.com/drugs/DB11642ApprovedInvestigationalPitolisant is a selective antagonist or inverse agonist of the histamine H3 receptor used to treat type 1 or 2 narcolepsy.
Categories: Histamine-3 Receptor Antagonist/Inverse Agonist, Histamine-3 (H3) Receptor Antagonists/Inverse AgonistsViltolarsen
go.drugbank.com/drugs/DB15005ApprovedInvestigationalDuchenne muscular dystrophy (DMD) is an X-linked recessive allelic disorder characterized by a lack of functional dystrophin protein, which leads to progressive ambulatory, pulmonary, and cardiac function and is invariably fatal. A relat...