Search
Calaspargase pegol
go.drugbank.com/drugs/DB14730ApprovedInvestigationalCalaspargase pegol, also known as _asparlas_, is an asparagine specific enzyme which is indicated as a part of a multi-agent chemotherapy regimen for the treatment of ALL [L4890]. … The asparagine specific enzyme is derived from Escherichia coli, as a conjugate of L-asparaginase (L-asparagine amidohydrolase) and monomethoxypolyethylene glycol (mPEG) with a succinimidyl carbonate (
Categories: Compounds used in a research, industrial, or household settingGimeracil
go.drugbank.com/drugs/DB09257ApprovedInvestigationalThis allows higher concentrations of 5-FU to be achieved with a lower dose of tegafur, thereby also reducing toxic side effects. … The main active ingredient in Teysuno is [DB09256], a pro-drug of [DB00544] (5-FU), which is a cytotoxic anti-metabolite drug that acts on rapidly dividing cancer cells.
Mixtures: TS-ONE OD Tablet 20, TS-ONE OD Tablet 25Acetyl sulfisoxazole
go.drugbank.com/drugs/DB14033ApprovedVet approvedThis process causes an inhibition of bacterial folic acid synthesis and de novo synthesis of purines and pyrimidines, resulting in cell growth arrest and cell death [L2788]. … Sulfisoxazole acetyl is an ester of _sulfisoxazole_, a broad-spectrum sulfanilamide and a synthetic analog of para-aminobenzoic acid (PABA) with antibacterial activity.
Categories: combinations of sulfonamidesClofarabine
go.drugbank.com/drugs/DB00631ApprovedInvestigationalClofarabine is used in paediatrics to treat a type of leukaemia called relapsed or refractory acute lymphoblastic leukaemia (ALL), only after at least two other types of treatment have failed. … Clofarabine is a purine nucleoside antimetabolite that is being studied in the treatment of cancer. It is marketed as Clolar in the U.S. and Canada, or Evoltra in Europe, Australia, and New Zealand.
Categories: OCT2 Substrates with a Narrow Therapeutic Index, OAT3/SLC22A8 Substrates with a Narrow Therapeutic IndexSynonyms: Cl-F-Ara-A, (2R,3R,4S,5R)-5-(6-amino-2-chloropurin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-olMoxidectin
go.drugbank.com/drugs/DB11431ApprovedInvestigationalVet approvedDue to these modifications, moxidectin is classified as a second generation macrocyclic lactone. … Moxidectin differs by the absence of a disaccharide moiety on carbon 13, a substituted olefinic side chain at carbon 25 and a unique methoxime moiety at carbon 23.
Mixtures: Advocate Spot-on Solution for Small Dogs, Advocate Spot-on Solution for Large DogsCategories: Compounds used in a research, industrial, or household settingSelenic acid
go.drugbank.com/drugs/DB11068ApprovedIt may be found in over-the-counter daily dietary supplements as a source of [DB11135], an essential trace mineral for human health. … Selenic acid is an organic compound with the chemical formula H2SeO4.
Mixtures: One-A-day Advance Men's, Beta A With Vitamins C and E Plus SeleniumCategories: Compounds used in a research, industrial, or household settingHydralazine
go.drugbank.com/drugs/DB01275ApprovedInvestigational[A186841] Hydralazine is a hydrazine derivative vasodilator used alone or as adjunct therapy in the treatment of hypertension and only as adjunct therapy in the treatment of heart failure. … [A186820,L8782,L8785] Hydralazine is no longer a first line therapy for these indications since the development of newer antihypertensive medications.
Mixtures: Ser-Ap-Es, Ser-AP-ES TabCategories: Arteriolar Smooth Muscle, Agents Acting OnBenzatropine
go.drugbank.com/drugs/DB00245ApprovedInvestigationalpotency for dopamine uptake inhibition as well as a decreased inhibition of serotonin and norepinephrine. … The generation of structure-activity relationships proved that benztropine derivatives with the presence of a chlorine substituent in the para position in one of the phenyl rings produces an increased
Categories: Ethers of Tropine or Tropine DerivativesPipradrol
go.drugbank.com/drugs/DB11584ApprovedWithdrawnPipradrol was made illegal in many countries in 1970s because of its potential for abuse. It is currently classified under the Misuse of Drugs Act as a Class C substance [L2522]. … Pipradrol (Meratran) [L2523] was initially developed in the 1950s as an antidepressant, however, the adverse effects associated with its use and its abuse potential led to its withdrawal and international
Empagliflozin
go.drugbank.com/drugs/DB09038ApprovedInvestigational[A203501] Attempts at overcoming these limitations first saw the development of O-glucoside analogs of phlorizin (e.g. … Empagliflozin is an inhibitor of sodium-glucose co-transporter-2 (SGLT2), the transporters primarily responsible for the reabsorption of glucose in the kidney.
Synonyms: (1S)-1,5-anhydro-1-(4-chloro-3-{4-[(3S)-tetrahydrofuran-3-yloxy]benzyl}phenyl)-D-glucitolMixtures: JARDIANZ DUO, JARDIANCE DUO