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Promazine
go.drugbank.com/drugs/DB00420ApprovedVet approvedWithdrawnA phenothiazine with actions similar to chlorpromazine but with less antipsychotic activity. It is primarily used in short-term treatment of disturbed behavior and as an antiemetic. … It is currently not approved for use in the United States.
Synonyms: N,N-dimethyl-3-(10H-phenothiazin-10-yl)-propan-1-amine, N-(3-Dimethylaminopropyl)phenothiazineCategories: Amino Acids, Peptides, and ProteinsMenotropins
go.drugbank.com/drugs/DB00032ApprovedInvestigationalIt is composed of LH with 2 subunits, alpha = 92 residues, beta = 121 residues and FSH with 2 subunits, alpha = 92 residues, beta=111 residues. … Menotropins contains follicle stimulating hormone (FSH) and luteinizing hormone (LH) purified from the urine of postmenopausal women.
Categories: Amino Acids, Peptides, and Proteins, Gonadotropins and AntigonadotropinsProducts: Menopur Powder for Injection and Solvent 75 IU, MENOPUR Multidose Powder and Solvent for Solution for Injection 600 IUSimoctocog alfa
go.drugbank.com/drugs/DB09108ApprovedThe harvested product is concentrated and purified by a series of chromatography steps. … plasma-derived FVIII, has been deleted and replaced by a 16 amino acid linker.
Categories: Amino Acids, Peptides, and ProteinsProducts: NUWIQ 500 UI, NUWIQ 2000 UINeomycin
go.drugbank.com/drugs/DB00994ApprovedInvestigationalVet approved[A175042] Neomycin is active against both gram-positive and gram-negative organisms and mediates its pharmacological action by binding to bacterial ribosomes and inhibiting protein synthesis, which is … caused by medical procedures in the ear.
Mixtures: Bus and Classroom Yellow, Care Bus and Classroom YellowCategories: Alimentary Tract and Metabolism, Blood and Blood Forming OrgansIntracellular Signalling Through Adenosine Receptor A2a and Adenosine
smpdb.ca/view/SMP0000320SignalingThe A2A receptor is also expressed in the brain, where it has important roles in the regulation of glutamate and dopamine release. … The A2A receptor is responsible for regulating myocardial blood flow by vasodilating the coronary arteries, which increases blood flow to the myocardium, but may lead to hypotension.
Drugs: ATP · Adenosine · Magnesium cation · Zinc · Cyclic adenosine monophosphate · Pyrophosphoric acidIntracellular Signalling Through Histamine H2 Receptor and Histamine
smpdb.ca/view/SMP0000335SignalingHistamine can mediate various actions by interacting with histamine receptors (H1, H2, H3 and H4). … Histamine is an organic nitrogenous compound that is involved in local immune responses and it is a neurotransmitter for brain.
Metabolism and Physiological Effects of Indoxyl glucoside (indican)
smpdb.ca/view/SMP0124742MetabolicIt is a uremic toxin as identified by the European Uremic Toxin Working Group and accumulates in the presence of Lactobacillus bacteria in the gut. … in tryptophan metabolism, leading to an increase in indican synthesis.
Metabolism and Phsyiological Effects of Asymmetric dimethylarginine (ADMA)
smpdb.ca/view/SMP0124747MetabolicL-arginine is obtained from protein-rich foods like red meat, poultry, dairy and eggs. It is absorbed in the intestine to the blood. … It enters cells in the body and is metabolized to ADMA via the enzyme protein arginine methyltransferase-1. ADMA inhibits nitric oxide synthase, preventing the formation of nitric oxide.
Metabolism and Physiological Effects of Symmetric dimethylarginine (SDMA)
smpdb.ca/view/SMP0124764MetabolicL-arginine is obtained from protein-rich foods like red meat, poultry, dairy and eggs. It is absorbed in the intestine to the blood. … It enters cells in the body and is metabolized to SDMA via the enzyme protein arginine methyltransferase-5 or protein arginine methyltransferase-7.
Metabolism and Physiological Effects of β-Hydroxybutyric acid
smpdb.ca/view/SMP0126987MetabolicIn the liver mitochondrial matrix, the enzyme can also catalyze the reverse reaction, a step in ketogenesis. Hepatocytes are the main cell type in the liver (~80%). … Glucose is metabolized into pyruvate through glycolysis in the cytoplasm, and pyruvate is completely oxidized to generate ATP through the TCA cycle and oxidative phosphorylation in the mitochondria.