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Guanylate cyclase soluble subunit alpha-2
go.drugbank.com/bio_entities/BE0003578TargetEnzymeHumansAlpha subunit of soluble guanylate cyclase (sGC), a central enzyme in nitric oxide (NO) signaling. Functions as the main intracellular receptor for NO. Upon NO binding, catalyzes the conversion of GTP to cyclic GMP (cGMP) and thereby tra...
Polypeptides: Guanylate cyclase soluble subunit alpha-2Synonyms: GCS-alpha-2Solute carrier family 22 member 2
go.drugbank.com/bio_entities/BE0003647TransporterCarrierHumansElectrogenic voltage-dependent uniporter that mediates the transport of a variety of organic cations such as endogenous bioactive amines, cationic drugs and xenobiotics (PubMed:9260930, PubMed:9687576). Functions as a Na(+)-independent, ...
Polypeptides: Solute carrier family 22 member 2Synonyms: Organic cation transporter 2Geranylgeranyl transferase type-2 subunit beta
go.drugbank.com/bio_entities/BE0004073TargetHumansCatalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A (PubMed:7991565). Catalytic su...
Polypeptides: Geranylgeranyl transferase type-2 subunit betaAmyloid beta precursor like protein 2
go.drugbank.com/bio_entities/BE0009093TargetHumansMay bind to the DNA 5'-GTCACATG-3'(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein.
Polypeptides: Amyloid beta precursor like protein 2Synonyms: APLP-2, Amyloid-like protein 2Far upstream element-binding protein 2
go.drugbank.com/bio_entities/BE0009095TargetHumansBinds to the dendritic targeting element and may play a role in mRNA trafficking (By similarity). Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that ...
Polypeptides: Far upstream element-binding protein 2Synonyms: FUSE-binding protein 25,6-dihydroxyindole-2-carboxylic acid oxidase
go.drugbank.com/bio_entities/BE0010503TargetHumansCatalyzes the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid in the presence of bound Cu(2+) ions, but not in the presence of Zn(2+) (PubMed:28661582
Polypeptides: 5,6-dihydroxyindole-2-carboxylic acid oxidaseC-X-C motif chemokine 2
go.drugbank.com/bio_entities/BE0010525TargetHumansGRO-beta(5-73) shows a highly enhanced hematopoietic activity
Polypeptides: C-X-C motif chemokine 2Synonyms: Macrophage inflammatory protein 2-alphaBaculoviral IAP repeat-containing protein 2
go.drugbank.com/bio_entities/BE0010675TargetHumansMulti-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling, and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ...
Polypeptides: Baculoviral IAP repeat-containing protein 2Synonyms: hIAP-2, Inhibitor of apoptosis protein 2Cyclic nucleotide-gated channel alpha-2
go.drugbank.com/bio_entities/BE0014924TargetHumansThe rise of intracellular Ca(2+) levels potentiates the olfactory response by activating Ca(2+)-dependent Cl(-) channels, but it also serves as a negative feedback signal to desensitize the channel for … Mediates odorant-induced cAMP-dependent Ca(2+) influx triggering neuron depolarization.
Polypeptides: Cyclic nucleotide-gated channel alpha-2Synonyms: CNG-2, CNG channel alpha-2Potassium channel subfamily T member 2
go.drugbank.com/bio_entities/BE0015626TargetHumansSodium-activated and chloride-activated potassium channel (PubMed:14684870, PubMed:16687497, PubMed:25214519, PubMed:27682982, PubMed:29069600, PubMed:29740868). Produces rapidly activating outward rectifier K(+) currents (PubMed:1468487...
Polypeptides: Potassium channel subfamily T member 2