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Displaying results 1 - 10 of 1512 in total
  1. Target

    Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide

    go.drugbank.com/bio_entities/BE0001300
    TargetHumans

    May act as a B-cell-associated adapter that regulates B-cell antigen receptor (BCR)-signaling downstream of PI3K

    Polypeptides: Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide
  2. Target

    Hyaluronan and proteoglycan link protein 3

    go.drugbank.com/bio_entities/BE0004935
    TargetHumans

    May function in hyaluronic acid binding

    Polypeptides: Hyaluronan and proteoglycan link protein 3Function: hyaluronic acid binding
  3. Target

    Signal transducer and activator of transcription 3

    go.drugbank.com/bio_entities/BE0003462
    TargetHumans

    Following JAK/STAT signaling activation and as part of a complex with NFATC3 and NFATC4, binds to the alpha-beta E4 promoter region of CRYAB and activates transcription in cardiomyocytes (By similarity … and IL6ST) (PubMed:9188471)

    Polypeptides: Signal transducer and activator of transcription 3
  4. Target

    Cleavage and polyadenylation specificity factor subunit 3

    go.drugbank.com/bio_entities/BE0021153
    TargetHumans

    Has endonuclease activity, and functions as an mRNA 3'-end-processing endonuclease (PubMed:30507380). Also involved in the histone 3'-end pre-mRNA processing (PubMed:30507380). … U7 snRNP-dependent protein that induces both the 3'-endoribonucleolytic cleavage of histone pre-mRNAs and acts as a 5' to 3' exonuclease for degrading the subsequent downstream cleavage product (DCP) of

    Polypeptides: Cleavage and polyadenylation specificity factor subunit 3Synonyms: Cleavage and polyadenylation specificity factor 73 kDa subunit, mRNA 3'-end-processing endonuclease CPSF-73
  5. Target

    Sodium- and chloride-dependent GABA transporter 3

    go.drugbank.com/bio_entities/BE0004733
    TargetHumans

    Can also mediate transport of beta-alanine and to a lower extent that of taurine and hypotaurine (By similarity) … Mediates sodium- and chloride-dependent transport of gamma-aminobutyric acid (GABA) (PubMed:7874447).

    Polypeptides: Sodium- and chloride-dependent GABA transporter 3Synonyms: GAT-3
  6. Target

    Bile acids

    go.drugbank.com/bio_entities/BE0004809
    TargetHumans

  7. Target

    Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)

    go.drugbank.com/bio_entities/BE0000423
    TargetTransporterHumans

    Transports non-alpha-amino acids such as beta-alanine with low affinity, and has a higher affinity for dipolar and cationic amino acids such as leucine and lysine (PubMed:18599538). … Amino acid transporter that plays an important role in the absorption of amino acids in the intestinal tract.

    Polypeptides: Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)Synonyms: Amino acid transporter ATB0+
  8. Target

    NACHT, LRR and PYD domains-containing protein 3

    go.drugbank.com/bio_entities/BE0010347
    TargetHumans

    NLRP3 activation stimuli include extracellular ATP, nigericin, reactive oxygen species, crystals of monosodium urate or cholesterol, amyloid-beta fibers, environmental or industrial particles and nanoparticles … Recruitment of pro-caspase-1 (proCASP1) to the NLRP3 inflammasome promotes caspase-1 (CASP1) activation, which subsequently cleaves and activates inflammatory cytokines IL1B and IL18 and gasdermin-D (GSDMD

    Polypeptides: NACHT, LRR and PYD domains-containing protein 3
  9. Target

    B- and T-lymphocyte attenuator

    go.drugbank.com/bio_entities/BE0010629
    TargetHumans

    Inhibitory receptor on lymphocytes that negatively regulates antigen receptor signaling via PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed:12796776, PubMed:14652006, PubMed:15568026, PubMed:18193050). … In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state.

    Polypeptides: B- and T-lymphocyte attenuatorSynonyms: B- and T-lymphocyte-associated protein
  10. Target

    Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A

    go.drugbank.com/bio_entities/BE0003558
    TargetHumans

    Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'-GMP, respectively (PubMed:10725373, PubMed:10906126, PubMed:11050148) … Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP (PubMed:10725373, PubMed:10906126, PubMed:11050148, PubMed:16330539).

    Polypeptides: Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11ASynonyms: cAMP and cGMP phosphodiesterase 11A