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Sphingolipid Signaling (Receptor)
smpdb.ca/view/SMP0524344SignalingSphingosine‑1‑phosphate (S1P) is a potent bioactive lipid mediator synthesized intracellularly by the phosphorylation of sphingosine by sphingosine kinases SphK1 and SphK2 at the plasma membrane and is … activation, Rho GTPase–driven cytoskeletal remodeling, and PI3K/Akt and MAPK pathways—S1P orchestrates context‑dependent outcomes such as migration, proliferation, contraction, or cytoskeletal organization in a
Enzymes: Ras-related C3 botulinum toxin substrate 2, Ras-related C3 botulinum toxin substrate 3Mercaptopurine Action Pathway
smpdb.ca/view/SMP0000428Drug action, inhibition of de novo synthesis of purine nucleotides, and inhibition of Ras-related C3 botulinum toxin substrate 1, which induces apoptosis of activated T cells. … The thioguanosine triphosphate metabolite also inhibits Ras-related C3 botulinum toxin substrate 1, a plasma membrane-associated small GTPase that regulates cellular processes, inducing apoptosis in activated
Drugs: Tetrahydrofolic acid · Ademetionine · Aspartic acid · L-Glutamine · Adenosine phosphate · Glutamic acid +26 moreEnzymes: Ras-related C3 botulinum toxin substrate 1, Adenylate cyclase type 10Azathioprine Action Pathway
smpdb.ca/view/SMP0000427Drug action, inhibition of de novo synthesis of purine nucleotides, and inhibition of Ras-related C3 botulinum toxin substrate 1, which induces apoptosis of activated T cells. … The thioguanosine triphosphate metabolite also inhibits Ras-related C3 botulinum toxin substrate 1, a plasma membrane-associated small GTPase that regulates cellular processes, inducing apoptosis in activated
Drugs: Tetrahydrofolic acid · Ademetionine · Aspartic acid · L-Glutamine · Adenosine phosphate · Glutamic acid +27 moreEnzymes: Ras-related C3 botulinum toxin substrate 1, Adenylate cyclase type 10Thioguanine Action Pathway (old)
smpdb.ca/view/SMP0000430Drug actionThe thioguanosine triphosphate metabolite also inhibits Ras-related C3 botulinum toxin substrate 1, a plasma membrane-associated small GTPase that regulates cellular processes, inducing apoptosis in activated … Thioguanine exerts cytotoxic effects via incorporation of thiodeoxyguanosine triphosphate into DNA and thioguanosine triphosphate into RNA and inhibition of Ras-related C3 botulinum toxin substrate 1,
Drugs: Tetrahydrofolic acid · Ademetionine · Aspartic acid · L-Glutamine · Adenosine phosphate · Glutamic acid +27 moreEnzymes: Ras-related C3 botulinum toxin substrate 1, Adenylate cyclase type 10Fc Epsilon Receptor I Signaling in Mast Cells
smpdb.ca/view/SMP0000358SignalingFc epsilon receptor 1 (Fc epsilon RI) is a high-affinity receptor for the Fc region of immunoglobulin E (IgE), an antibody isotope involved in allergies. … This activates the mast cells and results in degranulation, a process by which preformed granules containing histamine, proteoglycans, and serine proteases, are released.
Enzymes: Ras-related C3 botulinum toxin substrate 1, Protein kinase C alpha type