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Displaying results 1 - 10 of 605 in total
  1. Target

    Coagulation factor IX

    go.drugbank.com/bio_entities/BE0000364
    TargetHumans

    Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids … , and factor VIIIa (PubMed:8295821, PubMed:2592373, PubMed:20121197, PubMed:20121198, PubMed:1730085, PubMed:19846852, PubMed:39880037)

    Polypeptides: Coagulation factor IXSynonyms: Christmas factor
  2. Target

    Coagulation factor IX (F9)

    go.drugbank.com/bio_entities/BE0010964
    TargetHumans

  3. Target

    Coagulation factor VII

    go.drugbank.com/bio_entities/BE0000333
    TargetHumans

    Factor VIIa also converts factor IX to factor IXa in the presence of tissue factor and calcium (PubMed:271951) … In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis.

    Polypeptides: Coagulation factor VII
  4. Target

    Coagulation factor V

    go.drugbank.com/bio_entities/BE0000041
    TargetCarrierHumans

    It serves as a critical cofactor for the prothrombinase activity of factor Xa that results in the activation of prothrombin to thrombin

    Polypeptides: Coagulation factor VSynonyms: Proaccelerin, labile factor
  5. Target

    Coagulation factor X

    go.drugbank.com/bio_entities/BE0000216
    TargetEnzymeHumans

    Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting (PubMed:22409427, PubMed:39880037). … Triggers activation of the transcription factor NF-kappa-B in dermal microvascular endothelial cells and atrial tissues (PubMed:24041930, PubMed:35738824).

    Polypeptides: Coagulation factor XSynonyms: Stuart factor, Stuart-Prower factor
  6. Target

    Coagulation factor VIII

    go.drugbank.com/bio_entities/BE0000016
    TargetCarrierEnzymeHumans

    Factor VIII, along with calcium and phospholipid, acts as a cofactor for F9/factor IXa when it converts F10/factor X to the activated form, factor Xa

    Polypeptides: Coagulation factor VIIISynonyms: Antihemophilic factor
  7. Target

    Coagulation factor XI

    go.drugbank.com/bio_entities/BE0001021
    TargetHumans

    Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX

    Polypeptides: Coagulation factor XI
  8. Target

    Coagulation factor XII

    go.drugbank.com/bio_entities/BE0004672
    TargetHumans

    Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. … Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then trypsin cleaves it to beta-factor XIIa.

    Polypeptides: Coagulation factor XIISynonyms: Hageman factor
  9. Target

    Coagulation factor VIII (F8)

    go.drugbank.com/bio_entities/BE0010225
    TargetHumans

  10. Target

    Alcohol dehydrogenase

    go.drugbank.com/bio_entities/BE0001853
    TargetEnzymeGeobacillus stearothermophilus

    Thermophilic NAD(+)-dependent alcohol dehydrogenase. Bears mainly an ethanol-dehydrogenase activity.

    Polypeptides: Alcohol dehydrogenaseFunction: alcohol dehydrogenase (NAD+) activity