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Displaying results 1 - 10 of 100 in total
  1. Target

    Methionine aminopeptidase

    go.drugbank.com/bio_entities/BE0002012
    TargetEscherichia coli (strain K12)

    Removes the N-terminal methionine from nascent proteins. … Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

    Polypeptides: Methionine aminopeptidase
  2. Target

    Methionine synthase

    go.drugbank.com/bio_entities/BE0003310
    TargetThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)

    Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.

    Polypeptides: Methionine synthase
  3. Target

    Methionine synthase

    go.drugbank.com/bio_entities/BE0000734
    TargetEnzymeHumans

    MeCbl is an active form of cobalamin (vitamin B12) used as a cofactor for methionine biosynthesis. … efficiently cobalamin towards MTR in order to produce methionine (PubMed:16769880, PubMed:27771510)

    Polypeptides: Methionine synthaseSynonyms: Cobalamin-dependent methionine synthase, Vitamin-B12 dependent methionine synthase
  4. Target

    Methionine aminopeptidase

    go.drugbank.com/bio_entities/BE0001319
    TargetStaphylococcus aureus (strain MW2)

    Removes the N-terminal methionine from nascent proteins. … Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

    Polypeptides: Methionine aminopeptidase
  5. Target

    Methionine aminopeptidase

    go.drugbank.com/bio_entities/BE0004187
    TargetStaphylococcus aureus (strain Mu50 / ATCC 700699)

    Removes the N-terminal methionine from nascent proteins. … Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

    Polypeptides: Methionine aminopeptidase
  6. Target

    Methionine aminopeptidase 1

    go.drugbank.com/bio_entities/BE0004117
    TargetHumans

    Cotranslationally removes the N-terminal methionine from nascent proteins. … The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).

    Polypeptides: Methionine aminopeptidase 1
  7. Target

    Methionine synthase reductase

    go.drugbank.com/bio_entities/BE0000763
    TargetHumans

    Key enzyme in methionine and folate homeostasis responsible for the reactivation of methionine synthase (MTR/MS) activity by catalyzing the reductive methylation of MTR-bound cob(II)alamin (PubMed:17892308 … Also acts as a molecular chaperone for methionine synthase by stabilizing apoMTR and incorporating methylcob(III)alamin into apoMTR to form the holoenzyme (PubMed:16769880).

    Polypeptides: Methionine synthase reductaseFunction: [methionine synthase] reductase (NADPH) activity
  8. Target

    Methionine--tRNA ligase

    go.drugbank.com/bio_entities/BE0001537
    TargetEscherichia coli (strain K12)

    Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.

    Polypeptides: Methionine--tRNA ligase
  9. Target

    L-methionine gamma-lyase

    go.drugbank.com/bio_entities/BE0003208
    TargetEnzymePseudomonas putida

    Catalyzes the alpha,gamma-elimination of L-methionine to produce methanethiol, 2-oxobutanoate and ammonia (PubMed:6742420, PubMed:8586629). Is involved in L-methionine catabolism (PubMed:9190812). … In fact, shows a multicatalytic function since it also catalyzes gamma-replacement of L-methionine with thiol compounds, alpha,gamma-elimination and gamma-replacement reactions of L-homocysteine and its

    Polypeptides: L-methionine gamma-lyaseSynonyms: Methionine gamma-lyase, L-methioninase
  10. Target

    Methionine--tRNA ligase

    go.drugbank.com/bio_entities/BE0009227
    TargetPlasmodium falciparum (isolate 3D7)

    Polypeptides: Methionine--tRNA ligaseSynonyms: Methionine--tRNA ligase, putative