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Protein C Action Pathway
smpdb.ca/view/SMP0126878Drug actionProtein C is an endogenous plasma protein, a zymogen that interacts with thrombomodulin in order to be converted to its active form. … Activated Protein C acts as a serine protease that acts by inactivating coagulation factors V and VIII, decreasing clot formation.
Enzymes: Protein CPhospholipase C Signaling Pathway
smpdb.ca/view/SMP0063783SignalingIt functions to activate inositol lipid signalling pathways causing the hydrolysis of PIP2 by PLC to IP3 and diacylglycerol to activate protein kinase C. … Phospholipase C pathways is one of the major intracellular signalling pathways regulating hormones.
Drugs: CalciumEnzymes: Protein kinase C alpha type, RAC-alpha serine/threonine-protein kinaseMuscular Gs Protein Cascade
smpdb.ca/view/SMP0126976PhysiologicalThe transducer in this system is a heterotrimeric G protein, composed of three subunits: a Gα protein such as Gsα, and a complex of two tightly linked proteins called Gβ and Gγ in a Gβγ complex. … G proteins belong to the larger group of enzymes called GTPases. Heterotrimeric G proteins located within the cell are activated by G protein-coupled receptors (GPCRs) that span the cell membrane.
Enzymes: Protein kinase C alpha type, cAMP-dependent protein kinase catalytic subunit alphaMuscular Gi Protein Cascade
smpdb.ca/view/SMP0126972Physiologicalprotein kinase. … Gi protein alpha subunit is a family of heterotrimeric G protein alpha subunits.
Enzymes: Protein kinase C alpha type, Protein kinase C beta typeActivation of PKC Through G Protein-Coupled Receptor
smpdb.ca/view/SMP0000749SignalingG protein-coupled receptors sense stimuli outside the cell and transmit signals across the plasma membrane. Activation of protein kinase C (PKC) is one of the common signaling pathways. … When a class of GPCRs are activated by a ligand, they activate Gq protein to bind GTP instead of GDP.
Drugs: CalciumEnzymes: Protein kinase C alpha type, Guanine nucleotide-binding protein G(q) subunit alphaMuscular Gq Protien Cascade
smpdb.ca/view/SMP0126980PhysiologicalGq proteins couple to G protein-coupled receptors to activate beta-type phospholipase C (PLC-β) enzymes. … Gq protein alpha subunit is a family of heterotrimeric G protein alpha subunits.
Drugs: CalciumEnzymes: Protein kinase C alpha type, Guanine nucleotide-binding protein G(i) subunit alpha-1Esmirtazapine H1-Antihistamine Immune Response Action Pathway
smpdb.ca/view/SMP0175136Drug actionReducing the activity of the NF-κB immune response transcription factor through the phospholipase C and the phosphatidylinositol (PIP2) signalling pathways also decreases antigen presentation and the expression
Enzymes: Protein kinase C beta type, Protein kinase C alpha typeMianserin H1-Antihistamine Immune Response Action Pathway
smpdb.ca/view/SMP0175135Drug actionReducing the activity of the NF-κB immune response transcription factor through the phospholipase C and the phosphatidylinositol (PIP2) signalling pathways also decreases antigen presentation and the expression
Enzymes: Protein kinase C beta type, Protein kinase C alpha typeMirtazapine H1-Antihistamine Immune Response Action Pathway
smpdb.ca/view/SMP0175072Drug actionReducing the activity of the NF-κB immune response transcription factor through the phospholipase C and the phosphatidylinositol (PIP2) signalling pathways also decreases antigen presentation and the expression
Enzymes: Protein kinase C beta type, Protein kinase C alpha typeEpinastine H1-Antihistamine Immune Response Action Pathway
smpdb.ca/view/SMP0175131Drug actionReducing the activity of the NF-κB immune response transcription factor through the phospholipase C and the phosphatidylinositol (PIP2) signalling pathways also decreases antigen presentation and the expression
Enzymes: Protein kinase C beta type, Protein kinase C alpha type