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Displaying all 7 results
  1. Target

    Serine hydrolase BPHL

    go.drugbank.com/bio_entities/BE0004370
    TargetHumans

    Catalyzes the hydrolytic activation of amino acid ester prodrugs of nucleoside analogs such as valacyclovir and valganciclovir, converting them into their active forms (acyclovir and ganciclovir) (PubMed

    Synonyms: Valacyclovir hydrolase
  2. Target

    Afadin

    go.drugbank.com/bio_entities/BE0004342
    TargetHumans

    Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs) (By similarity). Nectin- and actin...

    Synonyms: ALL1-fused gene from chromosome 6 protein
  3. Target

    Interleukin-33

    go.drugbank.com/bio_entities/BE0010097
    TargetHumans

    Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells (PubMed:16286016, PubMed:19841166). Involved in the maturation of Th2 cells inducing the se...

    Synonyms: Nuclear factor from high endothelial venules
  4. Target

    Serine/threonine-protein kinase TAO2

    go.drugbank.com/bio_entities/BE0004632
    TargetHumans

    Serine/threonine-protein kinase involved in different processes such as membrane blebbing and apoptotic bodies formation DNA damage response and MAPK14/p38 MAPK stress-activated MAPK cascade. Phosphorylates itself, MBP, activated MAPK8, ...

    Synonyms: Kinase from chicken homolog C
  5. Target

    Serine/threonine-protein kinase TAO1

    go.drugbank.com/bio_entities/BE0009392
    TargetHumans

    Acts as a regulator of cytoskeleton stability by phosphorylating 'Thr-208' of MARK2, leading to activate MARK2 kinase activity and subsequent phosphorylation and detachment of MAPT/TAU from microtubules

    Synonyms: Kinase from chicken homolog B
  6. Target

    Forkhead box protein M1

    go.drugbank.com/bio_entities/BE0014280
    TargetHumans

    Transcription factor regulating the expression of cell cycle genes essential for DNA replication and mitosis (PubMed:19160488, PubMed:20360045). Plays a role in the control of cell proliferation (PubMed:19160488). Also plays a role in DN...

    Synonyms: Winged-helix factor from INS-1 cells
  7. Target

    Serine/threonine-protein kinase TAO3

    go.drugbank.com/bio_entities/BE0009393
    TargetHumans

    Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38...

    Synonyms: Kinase from chicken homolog A