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Displaying results 1 - 10 of 253 in total
  1. Target

    Homeobox protein engrailed-2

    go.drugbank.com/bio_entities/BE0004484
    TargetHumans

    Synonyms: Hu-En-2, Homeobox protein en-2
  2. Target

    Interphotoreceptor matrix proteoglycan 2

    go.drugbank.com/bio_entities/BE0004942
    TargetHumans

    Chondroitin sulfate- and hyaluronan-binding proteoglycan involved in the organization of interphotoreceptor matrix; may participate in the maturation and maintenance of the light-sensitive photoreceptor outer segment. Binds heparin

    Synonyms: IPM 200, Interphotoreceptor matrix proteoglycan of 200 kDa
  3. Target

    Transitional endoplasmic reticulum ATPase

    go.drugbank.com/bio_entities/BE0004572
    TargetHumans

    The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. … Mediates the endoplasmic reticulum-associated degradation of CHRNA3 in cortical neurons as part of the STUB1-VCP-UBXN2A complex (PubMed:26265139).

    Synonyms: 15S Mg(2+)-ATPase p97 subunit
  4. Target

    tRNA-dihydrouridine(20a/20b) synthase [NAD(P)+]-like

    go.drugbank.com/bio_entities/BE0022092
    EnzymeHumans

    Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs

    Polypeptides: tRNA-dihydrouridine(20a/20b) synthase [NAD(P)+]-like
  5. Target

    Protein S100-A12

    go.drugbank.com/bio_entities/BE0001206
    TargetHumans

    S100A12 is a calcium-, zinc- and copper-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response.

    Synonyms: EN-RAGE
  6. Target

    Interleukin-20

    go.drugbank.com/bio_entities/BE0020481
    TargetHumans

    Exert its effects via the type I IL-20 receptor complex consisting of IL20RA and IL20RB (PubMed:11706020). … Alternatively, can mediate its activity through a second receptor complex called type II IL-20 receptor complex composed of IL22RA1 and IL20RB (PubMed:11564763).

    Polypeptides: Interleukin-20Synonyms: IL-20
  7. Target

    Copper

    go.drugbank.com/bio_entities/BE0004825
    TargetHumans

  8. Target

    20-ketosteroid reductase (20-hydroxysteroid dehydrogenase)

    go.drugbank.com/bio_entities/BE0009795
    EnzymeHumans and other mammals

    Catalyzes the inactivation of 5alpha-DHT and progesterone converting them into 3alpha/beta-androstanediols and (20S)-hydroxypregn-4-en-3-one, respectively (PubMed:10998348, PubMed:24434280). … Catalyzes the reduction of progesterone to less potent progestogen (20S)-hydroxypregn-4-en-3-one likely regulating ligand availability for progesterone receptors (PubMed:10998348, PubMed:11013348, PubMed

    Synonyms: 20-alpha-HSDFunction: 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase [NAD(P)+] activity
  9. Target

    Matrix metalloproteinase-20

    go.drugbank.com/bio_entities/BE0003696
    TargetHumans

    Degrades amelogenin, the major protein component of the enamel matrix and two of the macromolecules characterizing the cartilage extracellular matrix: aggrecan and the cartilage oligomeric matrix protein (COMP

    Polypeptides: Matrix metalloproteinase-20Synonyms: MMP-20
  10. Target

    Hyaluronidase PH-20

    go.drugbank.com/bio_entities/BE0010041
    TargetHumans

    Involved in sperm-egg adhesion. Upon fertilization sperm must first penetrate a layer of cumulus cells that surrounds the egg before reaching the zona pellucida. The cumulus cells are embedded in a matrix containing hyaluronic acid which...

    Polypeptides: Hyaluronidase PH-20Synonyms: Sperm surface protein PH-20, Hyaluronoglucosaminidase PH-20