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Chloroquine Action Pathway
smpdb.ca/view/SMP0125864Drug actionChloroquine is an antimalarial drug used to treat susceptible infections with P. vivax, P. malariae, P. ovale, and P. falciparum. It is also used for second line treatment for rheumatoid arthritis. … The raised pH in endosomes, prevent virus particles from utilizing their activity for fusion and entry into the cell.
Indocyanine green acid form Drug Metabolism
smpdb.ca/view/SMP0130870MetabolicIndocyanine green acid form passes through the liver and is then excreted from the body mainly through the kidney. … Indocyanine green acid form is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis.
Drugs: Indocyanine green acid formMultiple Carboxylase Deficiency, Neonatal or Early Onset Form
smpdb.ca/view/SMP0000564DiseaseThe BTD gene encodes for biotinidase and the HLCS gene encodes for holocarboxylase synthetase. … Holocarboxylase synthetase deficiency also called Multiple Carboxylase Deficiency, Neonatal or Early Onset Form, is a rare inborn error of metabolism (IEM) and autosomal recessive disorder of either mutations
2-Hydroxyglutric Aciduria (D and L Form)
smpdb.ca/view/SMP0000136DiseaseD-2-Hydroxyglutaric Aciduria is an autosomal recessive disease caused by a mutation in the D2HGDH gene which does for D-2-Hydroxygluarate dehydrogenase. … L-2-Hydroxyglutaric Aciduria (D-2-Hydroxyglutaric Aciduria ) is an autosomal recessive disease caused by a mutation in the L2HGDH gene which codes for L-2-Hydroxygluarate dehydrogenase.
Drugs: Pyridoxal phosphate · Pyruvic acid · Biotin · Aspartic acid · L-Glutamine · Adenosine phosphate +17 moreMultiple Carboxylase Deficiency, Neonatal or Early Onset Form
smpdb.ca/view/SMP0125778DiseaseThe BTD gene encodes for biotinidase and the HLCS gene encodes for holocarboxylase synthetase. … Holocarboxylase synthetase deficiency also called Multiple Carboxylase Deficiency, Neonatal or Early Onset Form, is a rare inborn error of metabolism (IEM) and autosomal recessive disorder of either mutations
Fc Epsilon Receptor I Signaling in Mast Cells
smpdb.ca/view/SMP0000358SignalingFc epsilon receptor 1 (Fc epsilon RI) is a high-affinity receptor for the Fc region of immunoglobulin E (IgE), an antibody isotope involved in allergies.
Enzymes: Linker for activation of T-cells family member 1mTOR Signaling pathway
smpdb.ca/view/SMP0535455SignalingmTOR is a serine/threonine kinase forming two distinct multiprotein complexes—mTORC1 (composed of mTOR, Raptor, PRAS40, DEPTOR, and mLST8) and mTORC2 (composed of mTOR, Rictor, mSIN1, Protor, DEPTOR, and mLST8)—that integrate environment...
Enzymes: Cytosolic arginine sensor for mTORC1 subunit 1