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Displaying results 1 - 10 of 103 in total
  1. Target

    Apolipoprotein B-100

    go.drugbank.com/bio_entities/BE0009908
    TargetHumans

    Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). … Apo B-100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor

    Polypeptides: Apolipoprotein B-100Synonyms: Apo B-100
  2. Target

    mRNA of ApoB-100

    go.drugbank.com/bio_entities/BE0004845
    TargetHumans

  3. Target

    cDNA FLJ60754, moderately similar to Survival motor neuron protein

    go.drugbank.com/bio_entities/BE0009143
    TargetHumans

    Polypeptides: cDNA FLJ60754, moderately similar to Survival motor neuron proteinSynonyms: cDNA FLJ60754, moderately similar to Survival motor neuron protein
  4. Target

    Transitional endoplasmic reticulum ATPase

    go.drugbank.com/bio_entities/BE0004572
    TargetHumans

    The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic … Recruited to stalled replication forks by SPRTN: may act by mediating extraction of DNA polymerase eta (POLH) to prevent excessive translesion DNA synthesis and limit the incidence of mutations induced

    Synonyms: 15S Mg(2+)-ATPase p97 subunit
  5. Target

    Protein S100-A1

    go.drugbank.com/bio_entities/BE0001090
    TargetHumans

    In response to an increase in intracellular Ca(2+) levels, binds calcium which triggers conformational changes (PubMed:23351007). … Facilitates diastolic Ca(2+) dissociation and myofilament mechanics in order to improve relaxation during diastole (PubMed:11717446)

    Synonyms: S-100 protein alpha chain, S-100 protein subunit alpha
  6. Target

    Protein S100-B

    go.drugbank.com/bio_entities/BE0001177
    TargetHumans

    Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase (By similarity). … Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer (PubMed:20950652, PubMed:6487634).

    Synonyms: S-100 protein beta chain, S-100 protein subunit beta
  7. Target

    Vascular cell adhesion protein 1

    go.drugbank.com/bio_entities/BE0001114
    TargetHumans

    During inflammatory responses, binds ligands on the surface of activated endothelial cells to initiate the activation of calcium channels and the plasma membrane-associated small GTPase RAC1 leading to … Acts as a major regulator of leukocyte adhesion to the endothelium through interaction with different types of integrins (PubMed:10209034).

    Synonyms: INCAM-100
  8. Target

    Protein RIC-3

    go.drugbank.com/bio_entities/BE0009005
    TargetHumans

    Molecular chaperone which facilitates proper subunit assembly and surface trafficking of alpha-7 (CHRNA7) and alpha-8 (CHRNA8) nicotinic acetylcholine receptors (PubMed:12821669, PubMed:15504725, PubMed:16120769, PubMed:18691158, PubMed:...

    Synonyms: Resistant to inhibitor of cholinesterase 3
  9. Target

    Splicing factor, proline- and glutamine-rich

    go.drugbank.com/bio_entities/BE0008965
    TargetHumans

    Binds to pre-mRNA in spliceosome C complex, and specifically binds to intronic polypyrimidine tracts. Involved in regulation of signal-induced alternative splicing. … During splicing of PTPRC/CD45, a phosphorylated form is sequestered by THRAP3 from the pre-mRNA in resting T-cells; T-cell activation and subsequent reduced phosphorylation is proposed to lead to release

    Synonyms: 100 kDa DNA-pairing protein, DNA-binding p52/p100 complex, 100 kDa subunit
  10. Target

    Sortilin

    go.drugbank.com/bio_entities/BE0018732
    TargetHumans

    The receptor is then recycled back to the Golgi for another round of trafficking through its binding to the retromer. Also required for protein transport from the Golgi apparatus to the endosomes. … These vesicles provide a stable pool of SLC2A4 and confer increased responsiveness to insulin. May also mediate transport from the endoplasmic reticulum to the Golgi

    Synonyms: 100 kDa NT receptor