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Macrophage receptor MARCO
go.drugbank.com/bio_entities/BE0009001TargetHumansPattern recognition receptor (PRR) which binds Gram-positive and Gram-negative bacteria (PubMed:9468508). Also plays a role in binding of unopsonized particles by alveolar macrophages (By similarity). Binds to the secretoglobin SCGB3A2 (...
Polypeptides: Macrophage receptor MARCOBone marrow proteoglycan
go.drugbank.com/bio_entities/BE0002114TargetHumansCytotoxin and helminthotoxin. Also induces non-cytolytic histamine release from human basophils. Involved in antiparasitic defense mechanisms and immune hypersensitivity reactions. The proform acts as a proteinase inhibitor, reducing the...
Polypeptides: Bone marrow proteoglycanBone morphogenetic protein 10
go.drugbank.com/bio_entities/BE0010910TargetHumansRequired for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors s...
Polypeptides: Bone morphogenetic protein 10Forkhead box protein M1
go.drugbank.com/bio_entities/BE0014280TargetHumansTranscription factor regulating the expression of cell cycle genes essential for DNA replication and mitosis (PubMed:19160488, PubMed:20360045). Plays a role in the control of cell proliferation (PubMed:19160488). Also plays a role in DN...
Polypeptides: Forkhead box protein M1Bone morphogenetic protein 4
go.drugbank.com/bio_entities/BE0009000TargetHumansGrowth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including neurogenesis, vascular development, angiogenesis and osteogenesis (PubMed:31363885). Acts in concert with PTHLH/PTHRP to stim...
Polypeptides: Bone morphogenetic protein 4Synonyms: Bone morphogenetic protein 2BTATA-box-binding protein
go.drugbank.com/bio_entities/BE0012882TargetHumansTFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:2194289, PubMed:2363050 … During assembly of the core PIC on the promoter, as part of TFIID, TBP binds to and also bends promoter DNA, irrespective of whether the promoter contains a TATA box (PubMed:33795473).
Polypeptides: TATA-box-binding proteinSynonyms: TATA-box factorDisulfide bond formation protein B
go.drugbank.com/bio_entities/BE0004378TargetEscherichia coli (strain K12)Required for disulfide bond formation in some periplasmic proteins such as PhoA or OmpA. Acts by oxidizing the DsbA protein.
Polypeptides: Disulfide bond formation protein BF-box only protein 41
go.drugbank.com/bio_entities/BE0009024TargetHumansSubstrate-recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex. Required in the developing brain for neuronal migration and long-term cerebellar integrity.
Polypeptides: F-box only protein 41T-box transcription factor T
go.drugbank.com/bio_entities/BE0011656TargetHumansInvolved in the transcriptional regulation of genes required for mesoderm formation and differentiation. Binds to a palindromic T site 5'-TTCACACCTAGGTGTGAA-3' DNA sequence and activates gene transcription when bound to such a site
Polypeptides: T-box transcription factor TBone morphogenetic protein receptor type-1A
go.drugbank.com/bio_entities/BE0009272TargetHumansOn ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SM...
Polypeptides: Bone morphogenetic protein receptor type-1A