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Displaying results 1 - 10 of 49 in total
  1. Target

    Melanoma antigen preferentially expressed in tumors

    go.drugbank.com/bio_entities/BE0010493
    TargetHumans

    In the nucleus, the CRL2(PRAME) complex is recruited to epigenetically and transcriptionally active promoter regions bound by nuclear transcription factor Y (NFY) and probably plays a role in chromstin

    Polypeptides: Melanoma antigen preferentially expressed in tumors
  2. Target

    Membrane protein involved in aromatic hydrocarbon degradation

    go.drugbank.com/bio_entities/BE0003979
    TargetPseudomonas putida (strain F1 / ATCC 700007)

    Polypeptides: Membrane protein involved in aromatic hydrocarbon degradation
  3. Target

    Laminin subunit alpha-1

    go.drugbank.com/bio_entities/BE0002108
    TargetHumans

    As a subunit of laminin-1 (also known as laminin-111 or EHS laminin), it is involved in the stimulation of agrin-induced receptor clustering through a MuSK-independent pathway … As a ligand for alpha-dystroglycan, it is involved in a number of processes including epithelium branching morphogenesis, down-regulation of apoptotic signals in muscle via the activation of PI3K/AKT signaling

    Polypeptides: Laminin subunit alpha-1Synonyms: Laminin A chain, Laminin-1 subunit alpha
  4. Target

    Laminin subunit alpha-5

    go.drugbank.com/bio_entities/BE0002103
    TargetHumans

    Plays a role in the regulation of skeletogenesis, through a mechanism that involves integrin-mediated signaling and PTK2B/PYK2 (PubMed:33242826) … Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular

    Polypeptides: Laminin subunit alpha-5Synonyms: Laminin-10 subunit alpha, Laminin-11 subunit alpha
  5. Target

    Laminin subunit gamma-1

    go.drugbank.com/bio_entities/BE0002107
    TargetHumans

    As a subunit of laminin-1 (also known as laminin-111 or EHS laminin), it is involved in the stimulation of agrin-induced receptor clustering through a MuSK-independent pathway … Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular

    Polypeptides: Laminin subunit gamma-1Synonyms: Laminin B2 chain, Laminin-1 subunit gamma
  6. Target

    Laminin subunit alpha-3

    go.drugbank.com/bio_entities/BE0002111
    TargetEnzymeHumans

    Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular

    Polypeptides: Laminin subunit alpha-3Synonyms: Laminin-5 subunit alpha, Laminin-6 subunit alpha
  7. Target

    Laminin subunit beta-1

    go.drugbank.com/bio_entities/BE0002106
    TargetHumans

    As a subunit of laminin-1 (also known as laminin-111 or EHS laminin), it is involved in the stimulation of agrin-induced receptor clustering through a MuSK-independent pathway (By similarity) … Involved in the organization of the laminar architecture of the cerebral cortex (PubMed:23472759).

    Polypeptides: Laminin subunit beta-1Synonyms: Laminin B1 chain, Laminin-1 subunit beta
  8. Target

    Linear primary-alkylsulfatase

    go.drugbank.com/bio_entities/BE0003744
    TargetPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)

    In addition, contributes to the in vivo virulence of P.aeruginosa by playing a central role in the degradation of mucin, a glycoprotein that is the primary component of the mucus overlaying the host epithelial … Plays a role in the degradation of both protein and carbohydrate moieties in mucin via the release of sulfate from mucin, D-galactose 6-sulfate (Gal-6S) and N-acetyl-D-glucosamine 6-sulfate (GlcNAc-6S)

    Polypeptides: Linear primary-alkylsulfataseSynonyms: Type III linear primary-alkylsulfatase
  9. Target

    Interferon-inducible protein AIM2

    go.drugbank.com/bio_entities/BE0011287
    TargetHumans

    Inflammasomes are supramolecular complexes that assemble in the cytosol in response to pathogens and other damage-associated signals and play critical roles in innate immunity and inflammation (PubMed: … Also acts as a regulator of neurodevelopment via its role in the DNA damage response: acts by promoting neural cell death in response to DNA damage in the developing brain, thereby purging genetically

    Synonyms: Absent in melanoma 2
  10. Target

    GTP-binding protein Rheb

    go.drugbank.com/bio_entities/BE0004594
    TargetHumans

    In response to starvation, RHEB is inactivated by the TSC-TBC complex, preventing activation of mTORC1 (PubMed:24529379, PubMed:33157014). Has low intrinsic GTPase activity (PubMed:15340059) … In response to nutrients, growth factors or amino acids, specifically activates the protein kinase activity of MTOR, the catalytic component of the mTORC1 complex: acts by causing a conformational change

    Synonyms: Ras homolog enriched in brain