Search
Zolpidem Action Pathway (New)
smpdb.ca/view/SMP0125072Drug actionZolpidem binding to the GABAA receptor chloride channel macromolecular complex is thought to lead to the sedative, anticonvulsant, anxiolytic, and myorelaxant drug effects of the drug. … Zolpidem is a sedative hypnotic used for the short-term treatment of insomnia to improve sleep latency.
Zolpidem Predicted Metabolism Pathway
smpdb.ca/view/SMP0174792MetabolicMetabolites of Zolpidem are predicted with biotransformer.
Mitochondrial Complex II Deficiency
smpdb.ca/view/SMP0125754DiseaseInterestingly, complex II deficiency gene mutation carriers may be at an increased risk for certain cancers. … Because complex II is found in the mitochondria, CII deficiency is technically considered a mitochondrial disease.
Enzymes: Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial, Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrialPyruvate Dehydrogenase Complex Deficiency
smpdb.ca/view/SMP0125772DiseasePDHA1 encodes the pyruvate dehydrogenase complex (PDC) a critical complex that converts pyruvate from glycolysis to acetyl CoA for the citric acid cycle. … Pyruvate dehydrogenase complex deficiency results from a mutation in the E1-alpha polypeptide gene (PDHA1).
Enzymes: Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial2-Ketoglutarate Dehydrogenase Complex Deficiency
smpdb.ca/view/SMP0000549Diseaseoxoglutarate dehydrogenase complex (OGDC). … 2-Ketoglutarate dehydrogenase complex deficiency, also known as alpha-ketoglutarate dehydrogenase deficiency or oxoglutaric aciduria, is an autosomal recessive disorder of the Krebs cycle caused by a defective
Enzymes: Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial, Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrialPyruvate Dehydrogenase Complex Deficiency
smpdb.ca/view/SMP0000212DiseasePDHA1 encodes the pyruvate dehydrogenase complex (PDC) a critical complex that converts pyruvate from glycolysis to acetyl CoA for the citric acid cycle. … Pyruvate dehydrogenase complex deficiency results from a mutation in the E1-alpha polypeptide gene (PDHA1).
Enzymes: Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrialMitochondrial Complex II Deficiency
smpdb.ca/view/SMP0000548DiseaseInterestingly, complex II deficiency gene mutation carriers may be at an increased risk for certain cancers. … Because complex II is found in the mitochondria, CII deficiency is technically considered a mitochondrial disease.
Enzymes: Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial, Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrialCopper gluconate Drug Metabolism
smpdb.ca/view/SMP0130548MetabolicCopper gluconate passes through the liver and is then excreted from the body mainly through the kidney. … Copper gluconate is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis.
Drugs: Copper gluconate2-Ketoglutarate Dehydrogenase Complex Deficiency
smpdb.ca/view/SMP0125755Diseaseoxoglutarate dehydrogenase complex (OGDC). … 2-Ketoglutarate dehydrogenase complex deficiency, also known as alpha-ketoglutarate dehydrogenase deficiency or oxoglutaric aciduria, is an autosomal recessive disorder of the Krebs cycle caused by a defective
Enzymes: Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial, Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrialUndecoylium chloride iodine complex Drug Metabolism
smpdb.ca/view/SMP0130610MetabolicUndecoylium chloride iodine complex passes through the liver and is then excreted from the body mainly through the kidney. … Undecoylium chloride iodine complex is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis.