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  1. Pathway

    Venlafaxine Metabolism Pathway

    smpdb.ca/view/SMP0000636
    Drug metabolism

    Venlafaxine is well absorbed into the circulation system. Venlafaxine is also metabolized to N-desmethylvenlafaxine. The N-demethylation is catalyzed by CYP3A4 and CYP2C19. … Venlafaxine is exported via two transporters: Multidrug resistance protein 1 and ATP-binding cassette sub-family G member 2.

    Drugs: NADH · Venlafaxine · Mesoheme · Formaldehyde · Desvenlafaxine
  2. Pathway

    Desvenlafaxine SNRI - Serotonin reuptake Inhibition Action Pathway

    smpdb.ca/view/SMP0126423
    Drug action

    Venlafaxine and ODV are also weak inhibitors of dopamine reuptake. … The exact mechanism of action of venlafaxine in the treatment of various psychiatric conditions has not been fully elucidated; however, it is understood that venlafaxine and its active metabolite O-desmethylvenlafaxine

    Drugs: Pyridoxal phosphate · Tryptophan · Venlafaxine · Sapropterin · Iron · Mesoheme +2 more
  3. Pathway

    Desvenlafaxine SNRI - Norepinephrine reuptake Inhibition Action Pathway

    smpdb.ca/view/SMP0126425
    Drug action

    The exact mechanism of action of venlafaxine in the treatment of various psychiatric conditions has not been fully elucidated; however, it is understood that venlafaxine and its active metabolite O-desmethylvenlafaxine … Venlafaxine and desvenlafaxine are also weak inhibitors of dopamine reuptake.

    Drugs: Pyridoxal phosphate · Ascorbic acid · Tyrosine · Venlafaxine · Norepinephrine · Dopamine +6 more