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Melanoma antigen preferentially expressed in tumors
go.drugbank.com/bio_entities/BE0010493TargetHumansSubstrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex, which mediates ubiquitination of target proteins, leading to their degradation (PubMed:21822215, PubMed:26138980). The CRL2(PRAME) complex mediate...
Polypeptides: Melanoma antigen preferentially expressed in tumorsSynonyms: Preferentially expressed antigen of melanomaTriggering receptor expressed on myeloid cells 2
go.drugbank.com/bio_entities/BE0020451TargetHumansForms a receptor signaling complex with TYROBP which mediates signaling and cell activation following ligand binding (PubMed:10799849). Acts as a receptor for amyloid-beta protein 42, a cleavage product of the amyloid-beta precursor prot...
Polypeptides: Triggering receptor expressed on myeloid cells 2Synonyms: Triggering receptor expressed on monocytes 2Triggering receptor expressed on myeloid cells 1
go.drugbank.com/bio_entities/BE0001288TargetHumansCell surface receptor that plays important roles in innate and adaptive immunity by amplifying inflammatory responses (PubMed:10799849, PubMed:21393102). Upon activation by various ligands such as PGLYRP1, HMGB1 or HSP70, multimerizes an...
Polypeptides: Triggering receptor expressed on myeloid cells 1Synonyms: Triggering receptor expressed on monocytes 1Transmembrane channel-like protein 1
go.drugbank.com/bio_entities/BE0017493TargetHumansPore-forming subunit of the mechanotransducer (MET) non-selective cation channel complex located at the tips of stereocilia of cochlear hair cells and that mediates sensory transduction in the auditory system (By similarity). The MET com...
Synonyms: Transmembrane cochlear-expressed protein 1Transmembrane channel-like protein 2
go.drugbank.com/bio_entities/BE0017488TargetHumansPore-forming subunit of the mechanotransducer (MET) non-selective cation channel complex located at the tips of stereocilia of cochlear hair cells and that mediates sensory transduction in the auditory system (PubMed:11850618). The MET c...
Synonyms: Transmembrane cochlear-expressed protein 2Ubiquitin-like protein NEDD8
go.drugbank.com/bio_entities/BE0014813TargetHumansUbiquitin-like protein which plays an important role in cell cycle control and embryogenesis via its conjugation to a limited number of cellular proteins, such as cullins or p53/TP53 (PubMed:10318914, PubMed:10597293, PubMed:11953428, Pu...
Synonyms: Neural precursor cell expressed developmentally down-regulated protein 8Hepcidin
go.drugbank.com/bio_entities/BE0009858EnzymeTargetHumansLiver-produced hormone that constitutes the main circulating regulator of iron absorption and distribution across tissues. Acts by promoting endocytosis and degradation of ferroportin/SLC40A1, leading to the retention of iron in iron-exp...
Synonyms: Liver-expressed antimicrobial peptide 1Cell growth-regulating nucleolar protein
go.drugbank.com/bio_entities/BE0008958TargetMousePlays a role in the maintenance of the appropriate processing of 47S/45S pre-rRNA to 32S/30S pre-rRNAs and their subsequent processing to produce 18S and 28S rRNAs (By similarity). Also acts at the level of transcription regulation. Alon...
Synonyms: Protein expressed in male leptotene and zygotene spermatocytes 264Platelet-derived growth factor D
go.drugbank.com/bio_entities/BE0003411TargetHumansGrowth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Plays an important role in wound healing....
Synonyms: Iris-expressed growth factorProstaglandin D2 receptor 2
go.drugbank.com/bio_entities/BE0003561TargetHumansReceptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin-sensitive decreases in cAMP levels and Ca(2+) mobilization. PI3K signaling is also implicated in mediating PTGDR2 effect...
Synonyms: Chemoattractant receptor-homologous molecule expressed on Th2 cells