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Sphingolipid Signaling (Receptor)
smpdb.ca/view/SMP0524344SignalingThrough these receptor‑specific G protein couplings—spanning cAMP suppression, Ca²⁺ mobilization, PKC activation, Rho GTPase–driven cytoskeletal remodeling, and PI3K/Akt and MAPK pathways—S1P orchestrates
Enzymes: Sphingosine 1-phosphate receptor 2, Sphingosine 1-phosphate receptor 4Histamine H1 Receptor Activation
smpdb.ca/view/SMP0063452SignalingThis results in the dissociation of a Gαq-GTP monomer and a Gβγ dimer from the receptor . … Upon binding by histamine, the H1 receptor allosterically activates the G-protein by exchanging GDP for GTP at the G-protein's alpha subunit (Gαq).
Drugs: CalciumEnzymes: Histamine H1 receptor, Inositol 1,4,5-trisphosphate receptor type 1Minaprine Serotonin receptor Antidepressant Action Pathway
smpdb.ca/view/SMP0126747Drug actionMinaprine is an amino-phenylpyridazine antidepressant. It is indicated in the treatment of various depressive states. Minaprine acts on many targets in the neurons. Firstly, this drug binds as an antagonist to the serotonin type 2 recept...
Enzymes: 5-hydroxytryptamine receptor 2A, 5-hydroxytryptamine receptor 2CIntracellular Signalling Through Prostacyclin Receptor and Prostacyclin
smpdb.ca/view/SMP0000354SignalingThe receptor is a G-protein coupled receptor, upon its binding it activates G proteins causing the activation of adenylyl cyclase and production of cAMP messenger molecules. cAMP activates PKA (protein … Prostacyclin binding to its receptor increases vasodilation and decreases platelet aggregation.
Enzymes: Prostacyclin receptorTrimebutine M3 Receptor Intestine Relaxation Action Pathway
smpdb.ca/view/SMP0126338Drug actionTrimebutine is a spasmolytic agent used for the symptomatic treatment of irritable bowel syndrome (IBS) and treatment of postoperative paralytic ileus following abdominal surgery. Trimebutine is a spasmolytic agent that regulates intesti...
Drugs: ATP · Nitric Oxide · Potassium cation · Calcium · Magnesium cation · Cyclic adenosine monophosphate +3 moreEnzymes: Mu-type opioid receptor, Muscarinic acetylcholine receptor M3Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
smpdb.ca/view/SMP0000321SignalingThe adenosine receptor A2b activates G(s) proteins which lead to the activation of adenylyl cyclase which produces the secondary messenger cAMP. cAMP activates PKA (protein kinase A) which phosphorylates
Drugs: ATP · Adenosine · Magnesium cation · Zinc · Cyclic adenosine monophosphate · Pyrophosphoric acidEnzymes: Adenosine receptor A2bIntracellular Signalling Through Adenosine Receptor A2a and Adenosine
smpdb.ca/view/SMP0000320SignalingThe A2A receptor is also expressed in the brain, where it has important roles in the regulation of glutamate and dopamine release. … The A2A receptor is responsible for regulating myocardial blood flow by vasodilating the coronary arteries, which increases blood flow to the myocardium, but may lead to hypotension.
Drugs: ATP · Adenosine · Magnesium cation · Zinc · Cyclic adenosine monophosphate · Pyrophosphoric acidEnzymes: Adenosine receptor A2aIntracellular Signalling Through Histamine H2 Receptor and Histamine
smpdb.ca/view/SMP0000335SignalingThe H2 receptor activates G(s) proteins which lead to the activation of adenylyl cyclase which produces the secondary messenger cAMP. cAMP activates PKA (protein kinase A) which phosphorylates downstream
Enzymes: Histamine H2 receptorFc Epsilon Receptor I Signaling in Mast Cells
smpdb.ca/view/SMP0000358SignalingFc epsilon receptor 1 (Fc epsilon RI) is a high-affinity receptor for the Fc region of immunoglobulin E (IgE), an antibody isotope involved in allergies.
Enzymes: Growth factor receptor-bound protein 2, High affinity immunoglobulin epsilon receptor subunit alphaActivation of PKC Through G Protein-Coupled Receptor
smpdb.ca/view/SMP0000749SignalingIP3 can bind Ins3P receptor to open calcium channel by diffusion from cytoplasm to ER. Activated calcium channel will release the calcium from ER into cytoplasm.
Drugs: CalciumEnzymes: Inositol 1,4,5-trisphosphate receptor type 1