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Triggering receptor expressed on myeloid cells 2
go.drugbank.com/bio_entities/BE0020451TargetHumansForms a receptor signaling complex with TYROBP which mediates signaling and cell activation following ligand binding (PubMed:10799849). Acts as a receptor for amyloid-beta protein 42, a cleavage product of the amyloid-beta precursor prot...
Polypeptides: Triggering receptor expressed on myeloid cells 2Synonyms: Triggering receptor expressed on monocytes 2Triggering receptor expressed on myeloid cells 1
go.drugbank.com/bio_entities/BE0001288TargetHumansCell surface receptor that plays important roles in innate and adaptive immunity by amplifying inflammatory responses (PubMed:10799849, PubMed:21393102). Upon activation by various ligands such as PGLYRP1, HMGB1 or HSP70, multimerizes an...
Polypeptides: Triggering receptor expressed on myeloid cells 1Synonyms: Triggering receptor expressed on monocytes 1Polycomb protein SCMH1
go.drugbank.com/bio_entities/BE0004637TargetHumansAssociates with Polycomb group (PcG) multiprotein complexes; the complex class is required to maintain the transcriptionally repressive state of some genes
Synonyms: Sex comb on midleg homolog 1Immunoglobulin heavy constant mu
go.drugbank.com/bio_entities/BE0005098TargetHumansConstant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglo...
Synonyms: Ig mu chain C region OUProstaglandin D2 receptor 2
go.drugbank.com/bio_entities/BE0003561TargetHumansReceptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin-sensitive decreases in cAMP levels and Ca(2+) mobilization. PI3K signaling is also implicated in mediating PTGDR2 effect...
Synonyms: Chemoattractant receptor-homologous molecule expressed on Th2 cellsSPARC
go.drugbank.com/bio_entities/BE0002145TargetHumansAppears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites;...
Synonyms: ONNuclear receptor subfamily 0 group B member 1
go.drugbank.com/bio_entities/BE0000074TargetHumansNuclear receptor that lacks a DNA-binding domain and acts as a corepressor that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions (PubMed:12482977, PubMed:32433991). Component of a cascad...
Synonyms: DSS-AHC critical region on the X chromosome protein 1Immunoglobulin kappa constant
go.drugbank.com/bio_entities/BE0003836TargetHumansConstant region of immunoglobulin light chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglo...
Synonyms: Ig kappa chain C region OUAnoctamin-1
go.drugbank.com/bio_entities/BE0004746TargetHumansCalcium-activated chloride channel (CaCC) (PubMed:20056604, PubMed:22178883, PubMed:22946059, PubMed:32487539). Plays a role in transepithelial anion transport and smooth muscle contraction. Required for the normal functioning of the int...
Synonyms: Discovered on gastrointestinal stromal tumors protein 1