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5-hydroxytryptamine 2 receptor
go.drugbank.com/bio_entities/BE0004881TargetHumansPlays a role in the regulation of dopamine and 5-hydroxytryptamine release, 5-hydroxytryptamine uptake and in the regulation of extracellular dopamine and 5-hydroxytryptamine levels, and thereby affects … G protein-coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:12970106, PubMed:18703043, PubMed:19057895, PubMed:29398112, PubMed:7895773).
Polypeptides: 5-hydroxytryptamine receptor 2A, 5-hydroxytryptamine receptor 2BSynonyms: 5-HT-2, 5-HT-2A5-hydroxytryptamine receptor 2
go.drugbank.com/bio_entities/BE0004957TargetHumansPlays a role in the regulation of dopamine and 5-hydroxytryptamine release, 5-hydroxytryptamine uptake and in the regulation of extracellular dopamine and 5-hydroxytryptamine levels, and thereby affects … G protein-coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:12970106, PubMed:18703043, PubMed:19057895, PubMed:29398112, PubMed:7895773).
Polypeptides: 5-hydroxytryptamine receptor 2A, 5-hydroxytryptamine receptor 2BSynonyms: 5-HT-2, 5-HT-2ATryptophan 5-hydroxylase 2
go.drugbank.com/bio_entities/BE0000080EnzymeTargetHumansNeuron-specific enzyme that catalyzes the conversion of L-tryptophan into 5-hydroxy-L-tryptophan, the rate-limiting step in serotonin production, using Fe(2+) as cofactor and molecular oxygen and tetrahydrobiopterin
Polypeptides: Tryptophan 5-hydroxylase 2Synonyms: Tryptophan 5-monooxygenase 2Pyrroline-5-carboxylate reductase 2
go.drugbank.com/bio_entities/BE0000728TargetHumansOxidoreductase that catalyzes the last step in proline biosynthesis, which corresponds to the reduction of pyrroline-5-carboxylate to L-proline using NAD(P)H (PubMed:23024808, PubMed:2722838, PubMed:6894153
Polypeptides: Pyrroline-5-carboxylate reductase 2Synonyms: P5CR 2, P5C reductase 2Inosine-5'-monophosphate dehydrogenase 2
go.drugbank.com/bio_entities/BE0000722TargetEnzymeHumansCatalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays
Polypeptides: Inosine-5'-monophosphate dehydrogenase 2Synonyms: Inosine-5'-monophosphate dehydrogenase type II, IMPD 22'-5'-oligoadenylate synthase 1
go.drugbank.com/bio_entities/BE0004585TargetHumansCatalyzes the formation of 2'-5'-oligoadenylates (2-5A) from polymerization of ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent … Can generate high levels of 2',5'-oligoadenylates in transformed cells, targeting them to innate and adaptive immunesurveillance mechanisms (PubMed:40010341).
Polypeptides: 2'-5'-oligoadenylate synthase 1Synonyms: (2-5')oligo(A) synthase 1, 2-5A synthase 1Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2
go.drugbank.com/bio_entities/BE0002192TargetHumansForms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links
Polypeptides: Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2Synonyms: Lysyl hydroxylase 2Keratin-associated protein 5-2
go.drugbank.com/bio_entities/BE0004492TargetHumansIn the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through ...
Polypeptides: Keratin-associated protein 5-2Synonyms: Keratin-associated protein 5-8Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1
go.drugbank.com/bio_entities/BE0000087TargetHumansPart of a complex composed of PLOD1, P3H3 and P3H4 that catalyzes hydroxylation of lysine residues in collagen alpha chains and is required for normal assembly and cross-linkling of collagen fibrils (By similarity). Forms hydroxylysine r...
Polypeptides: Procollagen-lysine,2-oxoglutarate 5-dioxygenase 15-oxoprolinase
go.drugbank.com/bio_entities/BE0002268TargetEnzymeHumansCatalyzes the cleavage of 5-oxo-L-proline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate
Polypeptides: 5-oxoprolinaseSynonyms: 5-OPase, 5-oxo-L-prolinase