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Displaying results 1 - 10 of 13 in total
  1. Target

    GABA(A) Receptor Benzodiazepine Binding Site

    go.drugbank.com/bio_entities/BE0008668
    TargetHumans

    GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit … GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit

  2. Target

    DMD-001 gene (exon 51 target site)

    go.drugbank.com/bio_entities/BE0008666
    TargetHumans

  3. Target

    DMD gene (exon 53 viltolarsen target site)

    go.drugbank.com/bio_entities/BE0010012
    TargetHumans

  4. Target

    DMD gene (exon 45 casimersen target site)

    go.drugbank.com/bio_entities/BE0010036
    TargetHumans

  5. Target

    Beta-secretase 1

    go.drugbank.com/bio_entities/BE0000988
    TargetHumans

    Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-c...

    Synonyms: Beta-site APP cleaving enzyme 1, Beta-site amyloid precursor protein cleaving enzyme 1
  6. Target

    Beta-secretase 2

    go.drugbank.com/bio_entities/BE0021401
    TargetHumans

    Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-assoc...

    Synonyms: Beta-site APP cleaving enzyme 2, Beta-site amyloid precursor protein cleaving enzyme 2
  7. Target

    Endonuclease III-like protein 1

    go.drugbank.com/bio_entities/BE0013972
    EnzymeTargetHumans

    The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. … The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines.

    Synonyms: Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase
  8. Target

    Cytohesin-2

    go.drugbank.com/bio_entities/BE0002654
    TargetHumans

    Acts as a guanine-nucleotide exchange factor (GEF). Promotes guanine-nucleotide exchange on ARF1, ARF3 and ARF6. Activates ARF factors through replacement of GDP with GTP (By similarity). The cell membrane form, in association with ARL4 ...

    Synonyms: ARF nucleotide-binding site opener
  9. Target

    Cytohesin-3

    go.drugbank.com/bio_entities/BE0004433
    TargetHumans

    Promotes guanine-nucleotide exchange on ARF1 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. Plays a role in the epithelial polarization (By similarity)

    Synonyms: ARF nucleotide-binding site opener 3
  10. Target

    Endonuclease 8-like 1

    go.drugbank.com/bio_entities/BE0003175
    TargetHumans

    Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.

    Synonyms: DNA-(apurinic or apyrimidinic site) lyase Neil1Function: class I DNA-(apurinic or apyrimidinic site) endonuclease activity