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Displaying all 7 results
  1. Target

    Endothelial PAS domain-containing protein 1

    go.drugbank.com/bio_entities/BE0009679
    TargetHumans

    Transcription factor involved in the induction of oxygen regulated genes. Heterodimerizes with ARNT; heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters (By similarity). ...

    Polypeptides: Endothelial PAS domain-containing protein 1Synonyms: Member of PAS protein 2, PAS domain-containing protein 2
  2. Target

    Endothelin receptor type B

    go.drugbank.com/bio_entities/BE0000043
    TargetHumans

    Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system

    Synonyms: ET-B, ET-BR
  3. Target

    Endothelin-1 receptor

    go.drugbank.com/bio_entities/BE0000521
    TargetHumans

    The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3

    Synonyms: ET-A
  4. Target

    Solute carrier family 22 member 4

    go.drugbank.com/bio_entities/BE0000757
    TargetTransporterHumans

    Transporter that mediates the transport of endogenous and microbial zwitterions and organic cations (PubMed:10215651, PubMed:15107849, PubMed:15795384, PubMed:16729965, PubMed:20601551, PubMed:22206629, PubMed:22569296, PubMed:29530864)....

    Synonyms: ET transporter
  5. Target

    Hypoxia-inducible factor 1-alpha

    go.drugbank.com/bio_entities/BE0002374
    TargetHumans

    Functions as a master transcriptional regulator of the adaptive response to hypoxia (PubMed:11292861, PubMed:11566883, PubMed:15465032, PubMed:16973622, PubMed:17610843, PubMed:18658046, PubMed:20624928, PubMed:22009797, PubMed:30125331,...

    Synonyms: Member of PAS protein 1, PAS domain-containing protein 8
  6. Target

    Platelet glycoprotein 4

    go.drugbank.com/bio_entities/BE0010538
    TargetTransporterHumans

    Multifunctional glycoprotein that acts as a receptor for a broad range of ligands. Ligands can be of proteinaceous nature like thrombospondin, fibronectin, collagen or amyloid-beta as well as of lipidic nature such as oxidized low-densit...

    Synonyms: PAS-4, PAS IV
  7. Target

    Hypoxia-inducible factor 1

    go.drugbank.com/bio_entities/BE0010297
    TargetHumans

    Transcription factor that functions as an obligate heterodimerization partner for several basic helix-loop-helix PER-ARNT-SIM (bHLH-PAS) proteins.

    Synonyms: Member of PAS protein 1, PAS domain-containing protein 8