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Copper chaperone for superoxide dismutase
go.drugbank.com/bio_entities/BE0005815CarrierTargetHumansDelivers copper to copper zinc superoxide dismutase (SOD1)
Polypeptides: Copper chaperone for superoxide dismutaseReceptor for retinol uptake STRA6
go.drugbank.com/bio_entities/BE0009879TransporterHumansImportant for the homeostasis of vitamin A and its derivatives, such as retinoic acid (PubMed:18316031). … Accepts all-trans retinol from the extracellular retinol-binding protein RBP4, facilitates retinol transport across the cell membrane, and then transfers retinol to the cytoplasmic retinol-binding protein
Polypeptides: Receptor for retinol uptake STRA6Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide
go.drugbank.com/bio_entities/BE0001300TargetHumansMay act as a B-cell-associated adapter that regulates B-cell antigen receptor (BCR)-signaling downstream of PI3K
Polypeptides: Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositideAdvanced glycation end product-specific receptor
go.drugbank.com/bio_entities/BE0010032TransporterTargetHumansContributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons (PubMed:19906677). … Protects cells from DNA replication stress by localizing to damaged replication forks where it stabilizes the MCM2-7 complex and promotes faithful progression of the replication fork (PubMed:36807739).
Synonyms: Receptor for advanced glycation end products, Receptor for advanced glycosylation end productsCalcium-dependent secretion activator 2
go.drugbank.com/bio_entities/BE0008710TargetHumansRegulates neurotrophin release from granule cells leading to regulate cell differentiation and survival during cerebellar development.
Synonyms: Calcium-dependent activator protein for secretion 2Afadin
go.drugbank.com/bio_entities/BE0004342TargetHumansEssential for the organization of adherens junctions (PubMed:30463011)
Synonyms: ALL1-fused gene from chromosome 6 proteinHyaluronan mediated motility receptor
go.drugbank.com/bio_entities/BE0004702TargetHumansReceptor for hyaluronic acid (HA) (By similarity). Involved in cell motility (By similarity). When hyaluronan binds to HMMR, the phosphorylation of a number of proteins, including PTK2/FAK1 occurs.
Synonyms: Receptor for hyaluronan-mediated motilityCalcium-dependent secretion activator 1
go.drugbank.com/bio_entities/BE0008704TargetHumansCalcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates catecholamine loading o...
Synonyms: Calcium-dependent activator protein for secretion 1Interleukin-33
go.drugbank.com/bio_entities/BE0010097TargetHumansActs as a chemoattractant for Th2 cells, and may function as an 'alarmin', that amplifies immune responses during tissue injury (PubMed:17853410, PubMed:18836528). … Induces rapid UCP2-dependent mitochondrial rewiring that attenuates the generation of reactive oxygen species and preserves the integrity of Krebs cycle required for persistent production of itaconate
Synonyms: Nuclear factor from high endothelial venulesG protein-coupled bile acid receptor 1
go.drugbank.com/bio_entities/BE0005788TargetHumansG protein-coupled receptor for bile acid (PubMed:12419312, PubMed:12524422, PubMed:32698187, PubMed:32747649, PubMed:35858343). … Apart from their role in lipid dietary absorption and cholesterol catabolism, bile acids act as an important signaling molecule, involved in processes, such as energy expenditure or tissue inflammation
Synonyms: Membrane-type receptor for bile acids