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Displaying results 1 - 10 of 178 in total
  1. Target

    Insulin

    go.drugbank.com/bio_entities/BE0003491
    TargetHumans

    Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids.

    Polypeptides: Insulin
  2. Target

    Insulin receptor

    go.drugbank.com/bio_entities/BE0000033
    TargetHumans

    In addition to binding insulin, the insulin receptor can bind insulin-like growth factors (IGFI and IGFII). Isoform Short has a higher affinity for IGFII binding. … Receptor tyrosine kinase which mediates the pleiotropic actions of insulin.

    Polypeptides: Insulin receptor
  3. Target

    Insulin-degrading enzyme

    go.drugbank.com/bio_entities/BE0001183
    TargetEnzymeHumans

    Substrate binding induces important conformation changes, making it possible to bind and degrade larger substrates, such as insulin (PubMed:23922390, PubMed:26394692, PubMed:29596046). … Plays a role in the cellular breakdown of insulin, APP peptides, IAPP peptides, natriuretic peptides, glucagon, bradykinin, kallidin, and other peptides, and thereby plays a role in intercellular peptide

    Polypeptides: Insulin-degrading enzymeSynonyms: Insulin protease, Insulinase
  4. Target

    Insulin receptor substrate 1

    go.drugbank.com/bio_entities/BE0000977
    TargetHumans

    Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:7541045 … Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of

    Polypeptides: Insulin receptor substrate 1Function: insulin receptor binding
  5. Target

    Insulin receptor substrate 2

    go.drugbank.com/bio_entities/BE0021286
    TargetHumans

    Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:25879670 … Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of

    Polypeptides: Insulin receptor substrate 2
  6. Target

    Insulin receptor-related protein

    go.drugbank.com/bio_entities/BE0009451
    TargetHumans

    Receptor with tyrosine-protein kinase activity. Functions as a pH sensing receptor which is activated by increased extracellular pH. Activates an intracellular signaling pathway that involves IRS1 and AKT1/PKB

    Polypeptides: Insulin receptor-related protein
  7. Target

    Insulin-induced gene 2 protein

    go.drugbank.com/bio_entities/BE0021304
    TargetHumans

    Oxysterol-binding protein that mediates feedback control of cholesterol synthesis by controlling both endoplasmic reticulum to Golgi transport of SCAP and degradation of HMGCR (PubMed:12242332, PubMed:16606821, PubMed:32322062). Acts as ...

    Polypeptides: Insulin-induced gene 2 protein
  8. Target

    Insulin-like growth factor 1

    go.drugbank.com/bio_entities/BE0003418
    TargetHumans

    The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. … Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to

    Polypeptides: Insulin-like growth factor 1Synonyms: Insulin-like growth factor I
  9. Target

    Insulin-like growth factor 2

    go.drugbank.com/bio_entities/BE0010370
    TargetHumans

    The insulin-like growth factors possess growth-promoting activity (By similarity). Major fetal growth hormone in mammals. Plays a key role in regulating fetoplacental development.

    Polypeptides: Insulin-like growth factor 2Synonyms: Insulin-like growth factor II
  10. Target

    Insulin-induced gene 1 protein

    go.drugbank.com/bio_entities/BE0011639
    TargetHumans

    Oxysterol-binding protein that mediates feedback control of cholesterol synthesis by controlling both endoplasmic reticulum to Golgi transport of SCAP and degradation of HMGCR (PubMed:12202038, PubMed:12535518, PubMed:16168377, PubMed:16...

    Polypeptides: Insulin-induced gene 1 protein