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Paliperidone

go.drugbank.com/drugs/DB01267
ApprovedInvestigational

Paliperidone is the primary active metabolite of risperidone. The mechanism of action is unknown but it is likely to act via a similar pathway to risperidone. It has been proposed that the drug's therapeutic activity in schizophrenia is mediated through a combination of central dopamine Type 2 (D2) and serotonin Typ...

  1. Pathway

    Paliperidone Serotonin Antagonist Action Pathway

    smpdb.ca/view/SMP0126597
    Drug action

    Paliperidone is the primary active metabolite of risperidone. … Paliperidone, by contrast, is predominantly excreted unchanged in the urine The mechanism of action of paliperidone is unknown but it is likely to act via a similar pathway to risperidone as second generation

    Drugs: Pyridoxal phosphate · Tryptophan · Sapropterin · Paliperidone · Calcium · Iron +1 more
  2. Pathway

    Paliperidone Dopamine Antagonist Action Pathway

    smpdb.ca/view/SMP0126592
    Drug action

    Paliperidone is the primary active metabolite of risperidone. … Paliperidone, by contrast, is predominantly excreted unchanged in the urine The mechanism of action of paliperidone is unknown but it is likely to act via a similar pathway to risperidone as second generation

    Drugs: Pyridoxal phosphate · Tyrosine · Sapropterin · Dopamine · Levodopa · Paliperidone +2 more
  3. Indication

    Schizoaffective Disorders

    go.drugbank.com/conditions/DBCOND0033299
    Drugs: Paliperidone
  4. Pathway

    Risperidone Serotonin Antagonist Action Pathway

    smpdb.ca/view/SMP0126598
    Drug action

    Paliperidone is the primary active metabolite of risperidone. … Paliperidone, by contrast, is predominantly excreted unchanged in the urine. The major active metabolite, 9-hydroxyrisperidone, contributes to the pharmacological effects of this drug.

    Drugs: Pyridoxal phosphate · Tryptophan · Sapropterin · Risperidone · Paliperidone · Calcium +3 more
  5. Pathway

    Risperidone Dopamine Antagonist Action Pathway

    smpdb.ca/view/SMP0126599
    Drug action

    Paliperidone is the primary active metabolite of risperidone. … Paliperidone, by contrast, is predominantly excreted unchanged in the urine. The main route of risperidone metabolism is in the liver by the enzyme CYP2D6.

    Drugs: Pyridoxal phosphate · Tyrosine · Sapropterin · Risperidone · Dopamine · Levodopa +4 more
  6. Drug

    Risperidone

    go.drugbank.com/drugs/DB00734
    ApprovedInvestigational

    [Paliperidone], another commonly used SGA, is the primary active metabolite of risperidone (i.e. 9-hydroxyrisperidone).

  7. Drug

    Lumateperone

    go.drugbank.com/drugs/DB06077
    ApprovedInvestigational

    [L10902] Although there are several antipsychotics including [aripiprazole], [paliperidone] and [clozapine] available for clinical use, they are generally accompanied by significant metabolic and/or neurological

  8. Indication

    Schizophrenias

    go.drugbank.com/conditions/DBCOND0033618
    Drugs: Aripiprazole · Aripiprazole lauroxil · Asenapine · Brexpiprazole · Cariprazine · Chlorpromazine +28 more