Displaying drugs 3501 - 3525 of 11866 in total
Nicotine
Nicotine is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Nicotine is also important medically because of its presence in tobacco smoke.
Approved
Matched Categories: … Monoamine Oxidase A Inhibitors for interaction with Monoamine Oxidase A substrates …
Diphemanil
Approved
Vet approved
Withdrawn
Tripelennamine
A histamine H1 antagonist with low sedative action but frequent gastrointestinal irritation. It is used to treat asthma; HAY fever; urticaria; and rhinitis; and also in veterinary applications. Tripelennamine is administered by various routes, including topically.
Approved
Vet approved
Matched Description: … A histamine H1 antagonist with low sedative action but frequent gastrointestinal irritation. …
Teplizumab
Teplizumab (teplizumab-mzwv) is a humanized IgG1 kappa CD3-directed monoclonal antibody used to delay the onset of type 1 diabetes (T1D).[A241480,A241045,A241475,L44091] T1D is an autoimmune condition in which T cell-mediated destruction of pancreatic β cells leads to loss of insulin production, impaired glycemic control, and reliance on exogenous insulin. Anti-CD3 therapy...
Approved
Investigational
Matched Description: … Teplizumab (teplizumab-mzwv) is a humanized IgG1 kappa CD3-directed monoclonal antibody used to delay …
Tezepelumab
Asthma is a heterogeneous chronic obstructive respiratory disease with both "type 2" (T2) and T2-low endotypes characterized by reduced airflow, chronic inflammation, and airway remodelling.[A243764, A243769] Thymic stromal lymphopoietin (TSLP), an innate pleiotropic IL-2-family cytokine, has emerged as a key upstream regulator of chronic inflammation across asthma endotypes. Blocking the...
Approved
Investigational
Matched Description: … Asthma is a heterogeneous chronic obstructive respiratory disease with both "type 2" (T2) and T2-low ... A243769] Thymic stromal lymphopoietin (TSLP), an innate pleiotropic IL-2-family cytokine, has emerged as a ... [A243764, A243769, A243774]
Tezepelumab is a human monoclonal IgG2λ antibody directed against TSLP …
Taurolidine
Taurolidine is an antimicrobial used for the prevention of catheter-related infections. It is a derivative of the amino acid taurine.
It was first synthesized in the 1970s and was originally used as a prophylactic against intraperitoneal bacterial infections in patients with peritonitis. In November 2023, a catheter lock solution of...
Approved
Investigational
Matched Description: … It is a derivative of the amino acid [taurine]. ... It was first synthesized in the 1970s and was originally used as a prophylactic against intraperitoneal ... and Antifungal Drugs (LPAD pathway) for the prevention of catheter-related bloodstream infections in a …
Juniperus californica pollen
Juniperus californica pollen is the pollen of the Juniperus californica plant. Juniperus californica pollen is mainly used in allergenic testing.
Approved
Artemisia douglasiana pollen
Artemisia douglasiana pollen is the pollen of the Artemisia douglasiana plant. Artemisia douglasiana pollen is mainly used in allergenic testing.
Approved
Desloratadine
Desloratadine is a second generation, tricyclic antihistamine that which has a selective and peripheral H1-antagonist action. It is the active descarboethoxy metabolite of loratidine (a second generation histamine). Desloratidine has a long-lasting effect and does not cause drowsiness because it does not readily enter the central nervous system.
Approved
Investigational
Matched Description: … Desloratadine is a second generation, tricyclic antihistamine that which has a selective and peripheral ... It is the active descarboethoxy metabolite of loratidine (a second generation histamine). ... Desloratidine has a long-lasting effect and does not cause drowsiness because it does not readily enter …
Mebeverine
Mebeverine has been investigated for the treatment of Irritable Bowel Syndrome and Post-cholecystectomy Gastrointestinal Spasms.
Approved
Investigational
Lumateperone
Schizophrenia is a complex mental illness and impacts approximately 1% of the population. Although there are several antipsychotics including aripiprazole, paliperidone and clozapine available for clinical use, they are generally accompanied by significant metabolic and/or neurological adverse effects. Lumateperone is a newly approved 2nd generation antipsychotic currently indicated for the...
Approved
Investigational
Matched Description: … Schizophrenia is a complex mental illness and impacts approximately 1% of the population. ... [A189093]
Lumateperone is a newly approved 2nd generation antipsychotic currently indicated for the ... [A189093] Both characteristics lend to a more favourable adverse effect profile and ultimately safer …
Foreskin fibroblast (neonatal)
Foreskin fibroblast-like stromal cells (FDSCs) are progenitors isolated from human tissue that can differentiate into various cell types .
Also known as Dermagraft, this device is a cryopreserved human fibroblast-derived dermal substitute. Composed of fibroblasts, extracellular matrix, and a bioabsorbable scaffold, it effectively supports wound healing .
Dermagraft has only...
Approved
Matched Description: … Also known as Dermagraft, this device is a cryopreserved human fibroblast-derived dermal substitute. ... Composed of fibroblasts, extracellular matrix, and a bioabsorbable scaffold, it effectively supports ... Dermagraft has been combined with [DB10772] to create a drug beneficial to patients with open burn wounds …
Foreskin keratinocyte (neonatal)
Skin, the largest organ of the human body, plays the main role in protecting the body from mechanical damage. It is composed of epidermal, dermal and hypodermal layers. The barrier function of the skin owed to its avascular epidermal layer, which is made mainly of keratinocytes. The keratinocytes form a...
Approved
Matched Description: … Foreskin keratinocytes are a form of skin cells that are cultured as a skin cell replacement for wounds ... Keratinocytes are derived from neonatal foreskins and used to create a drug called _Apligraf_, a mixture ... To construct a "living" alternative, a dermal substitute based on collagen I gel was created with mesenchymal …
Diosmin
Chronic venous insufficiency is a common condition the western population. Compression and pharmacotherapy are frequently used to manage chronic venous insufficiency, improving circulation and symptoms of venous disease. Diosmin is a bioflavonoid isolated from various plants or synthesized from hesperidin. It is used for the improvement of capillary fragility or...
Approved
Investigational
Matched Description: … Diosmin is widely available over-the-counter and demonstrates a favourable a favorable safety profile ... Chronic venous insufficiency is a common condition the western population. ... [A232885]
Diosmin is a bioflavonoid isolated from various plants or synthesized from [hesperidin]. …
Voxilaprevir
Voxilaprevir is a Direct-Acting Antiviral (DAA) medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most common...
Approved
Investigational
Matched Description: … Voxilaprevir is a Direct-Acting Antiviral (DAA) medication used as part of combination therapy to treat ... HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 ... Voxilaprevir has been available since July 2017 in a fixed dose combination product with [sofosbuvir] …
Epcoritamab
Epcoritamab is an IgG1-bispecific antibody that simultaneously binds to CD3 on T-cells and CD20 on B-cells.[A259736,A258488,A259761,L46516] Epcoritamab promotes the activation and expansion of T-cells and, by being able to bind to both CD20 and CD3, it leads to the T-cell–mediated killing of CD20+ malignant B cells.[A259761,L46516] Diffuse large B-cell lymphoma...
Approved
Investigational
Matched Description: … for the treatment of a variety of hematologic malignancies. ... approval for this indication may be contingent upon verification and description of clinical benefit in a ... [L46516] It is administered subcutaneously and is currently being evaluated as a monotherapy and in combination …
Necitumumab
Necitumumab is an intravenously administered recombinant monoclonal IgG1 antibody used in the treatment of non-small cell lung cancer (NSCLC) as an EGFR antagonist. It functions by binding to epidermal growth factor receptor (EGFR) and prevents binding of its ligands, a process that is involved in cell proliferation, metastasis, angiogenesis, and...
Approved
Investigational
Matched Description: … functions by binding to epidermal growth factor receptor (EGFR) and prevents binding of its ligands, a ... Necitumumab is approved for use in combination with cisplatin and gemcitabine as a first-line treatment …
Phenylalanine
Phenylalanine is an essential aromatic amino acid that is a precursor of melanin, dopamine, noradrenalin (norepinephrine), and thyroxine.
Approved
Investigational
Nutraceutical
Matched Description: … Phenylalanine is an essential aromatic amino acid that is a precursor of melanin, [dopamine], [noradrenalin …
Levomefolic acid
Levomefolic acid (INN) is the metabolite of folic acid (Vitamin B9) and it is a predominant active form of folate found in foods and in the blood circulation, accounting for 98% of folates in human plasma . It is transported across the membranes including the blood-brain barrier into various tissues...
Approved
Investigational
Matched Description: … Levomefolate is approved as a food additive and is designated a GRAS (generally regarded as safe) compound ... stability required for use as a supplement [A19276]. ... Levomefolic acid (INN) is the metabolite of folic acid (Vitamin B9) and it is a predominant active form …
Lanolin alcohols
Lanolin alcohols are a complex combination of organic alcohols obtained by the hydrolysis of lanolin. It is administered as an ointment base with topical insulin and has shown to be antagonistic to wound healing. It is commonly used in allergenic testing.
Approved
Experimental
Matched Description: … Lanolin alcohols are a complex combination of organic alcohols obtained by the hydrolysis of lanolin. …
Darbepoetin alfa
Human erythropoietin with 2 aa substitutions to enhance glycosylation (5 N-linked chains), 165 residues (MW=37 kD). Produced in Chinese hamster ovary (CHO) cells by recombinant DNA technology.
Approved
Investigational
Delafloxacin
Delafloxacin is a fluoroquinolone antibiotic which has been used in trials studying the treatment and basic science of Gonorrhea, Hepatic Impairment, Bacterial Skin Diseases, Skin Structure Infections, and Community Acquired Pneumonia, among others. It was approved in June 2017 under the trade name Baxdela for use in the treatment of...
Approved
Investigational
Matched Description: … Delafloxacin is a fluoroquinolone antibiotic which has been used in trials studying the treatment and …
Atracurium besylate
A non-depolarizing neuromuscular blocking agent with short duration of action. Its lack of significant cardiovascular effects and its lack of dependence on good kidney function for elimination provide clinical advantage over alternate non-depolarizing neuromuscular blocking agents.
Approved
Matched Description: … A non-depolarizing neuromuscular blocking agent with short duration of action. …
Morpholinylmercaptobenzothiazole
Approved
Experimental
Strontium chloride Sr-89
Strontium chloride (Sr-89), initially FDA-approved in 1993, is used as a paliative therapeutic option to help relieve the pain from bone metastases. Strontium chloride is mainly used in cases of metastatic castrate-resistant prostate cancer. Bone metastases is a common and severe complication presented in advanced stages of the disease. It...
Approved
Investigational
Matched Description: … Strontium chloride (Sr-89), initially FDA-approved in 1993, is used as a paliative therapeutic option ... [A31264] Bone metastases is a common and severe complication presented in advanced stages of the disease ... There has been some cases of apparent tumor regression which has given it a potential tumoricidal effect …
Displaying drugs 3501 - 3525 of 11866 in total