Taurolidine is an antimicrobial derivative of taurine used for prophylaxis of catheter-related infections. It was first synthesized in the 1970s and was originally used as a prophylactic against intraperitoneal bacterial infections in patients with peritonitis.
- Mechanism
- Curator reviewed · 6 references
Taurolidine is a broad-spectrum antimicrobial with activity against both Gram-positive and Gram-negative bacteria, in addition to mycobacteria and certain strains of fungi. The mechanism of action of taurolidine and its active metabolites is non-specific and involves the irreversible binding of its methylol groups to microbial cell walls, resulting in a subsequent loss of cell wall integrity and eventual cell death. In addition, it appears to reduce bacterial adhesion to mammalian cells and neutralize bacterial endo- and exotoxins.
- Primary indication
- Taurolidine is indicated in combination with heparin to reduce the incidence of catheter-related bloodstream infections (CRBSI) in adult patients with kidney failure receiving chronic hemodialysis (HD) through a central venous catheter (CVC).Curator reviewed · 8 structured indications
- Formula / weight
- C7H16N4O4S2 · 284.35 g/mol (avg)
- First approval
- United States, 2024
- Code names
- W-3100M
- Brand names
Resolves to
AJKIRUJIDFJUKJ-UHFFFAOYSA-NSMILESO=S1(=O)CCN(CN2CCS(=O)(=O)NC2)CN1What you can answer from here — as of July 07, 2026
Which drugs share a target with Taurolidine, and which of those have an active Phase 3 trial?
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