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Displaying drugs 401 - 425 of 13692 in total

Stearic acid

Stearic acid (IUPAC systematic name: octadecanoic acid) is one of the useful types of saturated fatty acids that comes from many animal and vegetable fats and oils. It is a waxy solid.
Approved
Experimental
Matched Description: … It is a waxy solid. …
Matched Mixtures name: … For Sope …
Matched Products: … Dr.g A-clear Foam …

Prussian blue

Prussian blue is described as a deep blue pigment that is produced when the oxidation of ferrous ferrocyanide salts occurs. It contains ferric hexacyanoferrate(II) in a cubic lattice crystal structure. It is insoluble in water but also tends to form a colloid thus can exist in either colloidal or water-soluble...
Approved
Matched Description: … It is insoluble in water but also tends to form a colloid thus can exist in either colloidal or water-soluble ... It contains ferric hexacyanoferrate(II) in a cubic lattice crystal structure. ... It is orally administered for clinical purposes to be used as an antidote for certain kinds of heavy …
Matched Categories: … Compounds used in a research, industrial, or household setting …

Ferric cation

Iron is a transition metal with a symbol Fe and atomic number 26. By mass, it is the most common element on Earth. Iron is an essential element involved in various metabolic processes, including oxygen transport, deoxyribonucleic acid (DNA) synthesis, and energy production in electron transport . Resulting from inadequate...
Approved
Matched Description: … serum phosphorus levels in patients with chronic kidney disease on dialysis. ... Ferric citrate (tetraferric tricitrate decahydrate) is a phosphate binder indicated for the control of ... Iron is a transition metal with a symbol Fe and atomic number 26. …

Levosimendan

Levosimendan increases calcium sensitivity to myocytes by binding to troponin C in a calcium dependent manner. This increases contractility without raising calcium levels. It also relaxes vascular smooth muscle by opening adenosine triphosphate sensitive potassium channels. Levosimendan is used to manage acutely decompensated congestive heart failure.
Approved
Investigational
Matched Description: … Levosimendan increases calcium sensitivity to myocytes by binding to troponin C in a calcium dependent ... This increases contractility without raising calcium levels. …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Matched Products: … SIMDAX 2.5 MG/ML CONCENTRATE FOR SOLUTION FOR INFUSION …

Protamine sulfate

Since it's earliest discovery in salmon rine sperm heads in the late 1800's to its formal introduction via US FDA approval in 1939, protamine sulfate has occupied an important therapeutic niche as perhaps the only viable option for reversing the anticoagulant effect of heparin use for over 77 years [A174778,...
Approved
Matched Description: … dabigatran reversal - their cost of procurement and potential range in reversing all parenteral anticoagulants ... the only viable option for reversing the anticoagulant effect of heparin use for over 77 years [A174778 ... Since it's earliest discovery in salmon rine sperm heads in the late 1800's to its formal introduction …
Matched Products: … Protamine Sulphate 10mg/ml Solution for Injection …

Siltuximab

Siltuximab is a chimeric (human-mouse) monoclonal immunoglobulin G1-kappa antibody produced in a Chinese hamster ovary (CHO) cell line by recombinant DNA technology. Siltuximab prevents the binding of IL-6 to soluble and membrane-bound IL-6 receptors by forming high affinity complexes with human interleukin-6 (IL-6). Its use is indicated for the treatment...
Approved
Investigational
Matched Description: … Siltuximab is a chimeric (human-mouse) monoclonal immunoglobulin G1-kappa antibody produced in a Chinese ... Its use is indicated for the treatment of adult patients with multicentric Castleman's disease (MCD) ... It is administered as a 1 hour intravenous infusion every 3 weeks. …
Matched Categories: … Agents reducing cytokine levels …
Matched Products: … Sylvant 400mg Powder for Concentrate for Solution for Infusion ... Sylvant 100mg Powder for Concentrate for Solution for Infusion ... SYLVANT POWDER FOR CONCENTRATE FOR SOLUTION FOR INFUSION 100MG/VIAL …

Meropenem

Meropenem is a broad-spectrum carbapenem antibiotic. It is active against Gram-positive and Gram-negative bacteria. Meropenem exerts its action by penetrating bacterial cells readily and interfering with the synthesis of vital cell wall components, which leads to cell death. In August 2017, a combination antibacterial therapy under the market name vabomere...
Approved
Investigational
Matched Description: … In August 2017, a combination antibacterial therapy under the market name vabomere was approved for treatment ... Meropenem is a broad-spectrum carbapenem antibiotic. …
Matched Categories: … Antibacterials for Systemic Use ... Antiinfectives for Systemic Use …
Matched Products: … Pospenem Powder for Solution for Injection 1g ... Pospenem Powder for Solution for Injection 500mg ... ARCHIFAR 1G POWDER FOR SOLUTION FOR INJECTION/INFUSION …

Ancrod

Ancrod, marketed as Viprinex, is a defibrinogenating agent derived from Malayan pit viper venom. The defribrinogenation of blood results in an anticoagulant effect. Currently, Viprinex®/ancrod is not approved or marketed in any country, but is being investigated as a stroke treatment in worldwide clinical trials. In January 2005, the U.S....
Approved
Investigational
Matched Description: … FDA granted a 'fast-track status' for investigation of ancrod use in patients suffering from acute ischemic ... a stroke treatment in worldwide clinical trials. ... to portions of the brain, for which phase III trials are currently being conducted. …
Matched Categories: … Venombin A …

Pectin

Pectin is a heteropolysaccharide commercially derived from the cell wall of higher plants. It is composed of partially methylated polygalacturonic acid units linked in the positions 1-4. The carboxylic group of the constituents of pectin can exist in the form of esters, free acids, ammonium, potassium or sodium salts or...
Approved
Investigational
Vet approved
Matched Description: … Pectin is a heteropolysaccharide commercially derived from the cell wall of higher plants. ... [A32327] It is composed of partially methylated polygalacturonic acid units linked in the positions 1 ... [L1961] The carboxylic group of the constituents of pectin can exist in the form of esters, free acids …
Matched Categories: … Compounds used in a research, industrial, or household setting …

Desogestrel

Desogestrel, a prodrug, is a third generation progestogen and hence, a member of the gonane family which was largely used in Europe before being approved in the US and Canada. It was firstly generated from a study that showed that 11-beta and 11-alkylidene substituent in nortestosterone can enhance the biological...
Approved
Matched Iupac: … -11a-ethyl-1-ethynyl-10-methylidene-1H,2H,3H,3aH,3bH,4H,5H,7H,8H,9H,9aH,9bH,10H,11H,11aH-cyclopenta[a] …
Matched Description: … Desogestrel, a prodrug, is a third generation progestogen[A176315] and hence, a member of the gonane ... FDA approved in 1992. ... family which was largely used in Europe before being approved in the US and Canada. …
Matched Categories: … Hormonal Contraceptives for Systemic Use …

Radium Ra 223 dichloride

Radium Ra 223 Dichloride is a radiopharmaceutical containing the radioisotope radium-223 that emits short range but high linear energy alpha particles. As a cation, radium mimics calicum and binds to hydroxyapatite, which is a bone mineral found in areas of high bone turnover as seen in bone metastases. It was...
Approved
Investigational
Matched Description: … As a cation, radium mimics calicum and binds to hydroxyapatite, which is a bone mineral found in areas ... The FDA label includes a warning that Radium Ra 223 Dichloride should not be used in women who are pregnant ... of high bone turnover as seen in bone metastases. …
Matched Products: … XOFIGO SOLUTION FOR INJECTION 1100kBq/ML ... Xofigo (Radium-223 Dichloride) 1100 kBq/mL Solution for Injection …

Bosentan

Bosentan is a dual endothelin receptor antagonist marketed under the trade name Tracleer by Actelion Pharmaceuticals. Bosentan is used to treat pulmonary hypertension by blocking the action of endothelin molecules that would otherwise promote narrowing of the blood vessels and lead to high blood pressure.
Approved
Investigational
Matched Description: … Bosentan is a dual endothelin receptor antagonist marketed under the trade name Tracleer by Actelion …
Matched Categories: … Antihypertensives for Pulmonary Arterial Hypertension …
Matched Products: … N/A …

Deutetrabenazine

Deutetrabenazine is a novel, highly selective vesicular monoamine transporter 2 (VMAT2) inhibitor indicated for the management of chorea associated with Huntington’s disease. It is a hexahydro-dimethoxybenzoquinolizine derivative and a deuterated DB04844 . The presence of deuterium in deutetrabenazine increases the half-lives of the active metabolite and prolongs their pharmacological activity...
Approved
Investigational
Matched Iupac: … (3S,11bS)-9,10-di(2H3)methoxy-3-(2-methylpropyl)-1H,2H,3H,4H,6H,7H,11bH-pyrido[2,1-a]isoquinolin-2-one …
Matched Description: … for the uptake of dopamine into synaptic vesicles in monoaminergic neurons and exocytotic release [A14081 ... As with other agents for the treatment of neurodegenerative diseases, deutetrabenazine is a drug to alleviate ... This allows less frequent dosing and a lower daily dose with improvement in tolerability [A32043]. …

Lutetium Lu-177 vipivotide tetraxetan

Lutetium Lu-177 vipivotide tetraxetan is a radioligand therapeutic agent. It consists of a radionuclide, lutetium Lu-177, linked to a moiety that binds to PSMA, a transmembrane protein that is expressed in prostate cancer. Lutetium Lu-177 vipivotide tetraxetan was first approved by the FDA on March 23, 2022 as a treatment...
Approved
Matched Description: … [L41290] In October 2022, the EMA's Committee for Medicinal Products for Human Use (CHMP) recommended ... protein that is expressed in prostate cancer. ... It consists of a radionuclide, [lutetium Lu-177], linked to a moiety that binds to PSMA, a transmembrane …
Matched Categories: … Compounds used in a research, industrial, or household setting …

Isocarboxazid

Isocarboxazid has the formula 1-benzyl-2-(5-methyl-3-isoxazolylcarbonyl)hydrazine-isocarboxazid. It is a monoamine oxidase inhibitor. It is used in the treatment of major depression, dysthymic disorder, atypical disorder, panic disorder and the phobic disorders. It was first introduced by Roche pharmaceuticals, further developed by Validus pharms Inc and first FDA approved as a prescription...
Approved
Matched Description: … It is a monoamine oxidase inhibitor. ... [A31930] It is used in the treatment of major depression, dysthymic disorder, atypical disorder, panic ... introduced by Roche pharmaceuticals, further developed by Validus pharms Inc and first FDA approved as a …
Matched Categories: … Monoamine Oxidase A Inhibitors for interaction with Monoamine Oxidase A substrates ... Antidepressive Agents Indicated for Depression …

Spinosad

Spinosad is a pediculicide mixture of spinosyn A and spinosyn D (in an approximately 5:1 ratio, respectively) used in the topical treatment of head lice in children (four years old and older) and in adults. Spinosad is an insecticide based on a compound found in S. spinosa, a bacterial species....
Approved
Investigational
Vet approved
Matched Description: … Spinosad is an insecticide based on a compound found in S. spinosa, a bacterial species. ... Spinosad is a pediculicide mixture of spinosyn A and spinosyn D (in an approximately 5:1 ratio, respectively ... Spinosad has also been experimented for use in cats for treatment of flea infestations, and has also …
Matched Mixtures name: … Comfortis Plus (Spinosad + Milbemycin oxime) Chewable Tablets for Dogs 9.1-18kg ... Comfortis Plus (Spinosad + Milbemycin oxime) Chewable Tablets for Dogs 18.1-27kg ... Comfortis Plus (Spinosad + Milbemycin oxime) Chewable Tablets for Dogs 4.6-9kg …
Matched Categories: … Compounds used in a research, industrial, or household setting …

Nelarabine

Nelarabine is an antineoplastic agent that is typically used to treat acute T-cell lymphoblastic leukemia, particularly T-cell acute lymphoblastic leukemia (T-ALL) and T-cell lymphoblastic lymphoma (T-LBL), in both adult and pediatric patients whose disease has not responded to or has relapsed following at least two chemotherapy regimens. T-cell acute lymphoblastic...
Approved
Investigational
Matched Description: … nelarabine can yield a 13% complete response (CR) rate in pediatric patients and 18% in adult patients ... [L40878] Nelarabine preferentially accumulates in T-cells since T-cells have a higher expression of enzymes ... used to treat acute T-cell lymphoblastic leukemia, particularly T-cell acute lymphoblastic leukemia (T-ALL …

Dasiglucagon

Dasiglucagon is a glucagon analog that acts to increase blood sugar levels. It consists of 29 amino acids similar to endogenous glucagon; however, it contains seven substituted amino acids for improved physical and chemical stability in its drug formulation. In March 2021, the FDA approved dasiglucagon to treat severe hypoglycemia...
Approved
Investigational
Matched Description: … drop in blood glucose levels. ... Dasiglucagon is a glucagon analog that acts to increase blood sugar levels. ... hypoglycemic events in patients with diabetes, and children are particularly at risk for experiencing …

Imlifidase

Chronic kidney disease (CKD) is a progressive and irreversible disease that represents a significant burden for both the individual and healthcare system at large. Currently available treatments for end-stage renal disease are limited to dialysis and renal transplantation, with the former associated with significant costs and lower quality of life.[A225836,A225916]...
Approved
Investigational
Matched Description: … in highly sensitized patients to proceed. ... burden for both the individual and healthcare system at large. ... [A225836] High levels of anti-HLA antibodies also contribute to poor graft survival. …

Rucaparib

Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the genetically-mutated cancer...
Approved
Investigational
Matched Description: … ; however, it causes a unique effect of synthetic lethality. ... By targeting the genetically-mutated cancer cells that lack a DNA repair mechanism, rucaparib causes ... and accelerated approval in December 2016. …
Matched Categories: … P-glycoprotein substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP1A2 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP2D6 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index …

Tezepelumab

Asthma is a heterogeneous chronic obstructive respiratory disease with both "type 2" (T2) and T2-low endotypes characterized by reduced airflow, chronic inflammation, and airway remodelling.[A243764, A243769] Thymic stromal lymphopoietin (TSLP), an innate pleiotropic IL-2-family cytokine, has emerged as a key upstream regulator of chronic inflammation across asthma endotypes. Blocking the...
Approved
Investigational
Matched Description: … produced in Chinese hamster ovary (CHO) cells by recombinant DNA technology. ... 7Rα improves asthma-associated biomarkers including eosinophil counts and IgE, FeNO, IL-5, and IL-13 levels ... Asthma is a heterogeneous chronic obstructive respiratory disease with both "type 2" (T2) and T2-low …
Matched Categories: … Drugs for Obstructive Airway Diseases …

Difluocortolone

Difluocortolone is a potent topical corticosteroid. It is commonly used in dermatology for the reduction of inflammation and itching. It was submitted to the FDA in July 1984 by the pharmaceutical company Schering AG.
Approved
Investigational
Withdrawn
Matched Iupac: … hydroxy-1-(2-hydroxyacetyl)-2,9a,11a-trimethyl-1H,2H,3H,3aH,3bH,4H,5H,7H,9aH,9bH,10H,11H,11aH-cyclopenta[a] …
Matched Description: … It is commonly used in dermatology for the reduction of inflammation and itching. ... Difluocortolone is a potent topical corticosteroid. ... It was submitted to the FDA in July 1984 by the pharmaceutical company Schering AG.[L1082] …

Escitalopram

Escitalopram is a selective serotonin re-uptake inhibitor (SSRI) and the S-enantiomer of racemic citalopram. It is used to restore serotonergic function in the treatment of depression and anxiety.[L8513,L8516,L8522] Escitalopram is approximately 150 times more potent than citalopram’s R-enantiomer and is responsible for the vast majority of citalopram’s clinical activity, with...
Approved
Matched Description: … Escitalopram is a selective serotonin re-uptake inhibitor (SSRI) and the S-enantiomer of racemic [citalopram ... [A185420] It is used to restore serotonergic function in the treatment of depression and anxiety. ... other off-targets which may explain its lower rates of adverse effects as compared to other agents in …
Matched Categories: … Monoamine Oxidase A Substrates ... Antidepressive Agents Indicated for Depression …

Metoclopramide

Diabetic gastroparesis is a condition that causes frequent nausea and vomiting, which has a negative impact on quality of life and poses a significant burden on the healthcare system. Metoclopramide is a dopamine antagonist used to treat nausea and vomiting that may be associated with diabetic gastroparesis in addition to...
Approved
Investigational
Matched Description: … Diabetic gastroparesis is a condition that causes frequent nausea and vomiting, which has a negative ... It is available in the oral tablet form or in solution, and can also be administered through the intravenous ... [T683] Metoclopramide was initially approved by the FDA in 1980.[A184922] …
Matched Categories: … Drugs for Functional Gastrointestinal Disorders …

Interferon alfacon-1

Interferon alfacon-1 is a recombinant non-naturally occurring type-I interferon. The 166-amino acid sequence of Interferon alfacon-1 was derived by scanning the sequences of several natural interferon alpha subtypes and assigning the most frequently observed amino acid in each corresponding position. Four additional amino acid changes were made to facilitate the...
Approved
Investigational
Matched Description: … by insertion of a synthetically constructed sequence that codes for Interferon alfacon-1. ... of several natural interferon alpha subtypes and assigning the most frequently observed amino acid in ... Interferon alfacon-1 is produced in Escherichia coli (E. coli) cells that have been genetically altered …
Displaying drugs 401 - 425 of 13692 in total