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Displaying drugs 826 - 850 of 15521 in total
Compound used for therapy of thiamine deficiency. It has also been suggested for several non-deficiency disorders but has not yet proven useful. Fursultiamine is a vitamin B1 derivative.
Approved
Matched International brands: … Alinamin F
Matched Iupac: … N-[(4-amino-2-methylpyrimidin-5-yl)methyl]-N-[(2E)-5-hydroxy-3-{[(oxolan-2-yl)methyl]disulfanyl}pent- ... 2-en-2-yl]formamide …
Matched Description: … Fursultiamine is a vitamin B1 derivative. ... Compound used for therapy of thiamine deficiency. ... It has also been suggested for several non-deficiency disorders but has not yet proven useful. …
Matched Salts cas: … 2105-43-3
Matched Mixtures name: … ALINAMIN-F ODORLESS TABLET …
A derivative of procaine with less CNS action.
Approved
Matched Synonyms: … p-Amino-N-(2-diethylaminoethyl)benzamide …
Matched Iupac: … 4-amino-N-[2-(diethylamino)ethyl]benzamide …
Matched Description: … A derivative of procaine with less CNS action. …
Matched Categories: … MATE 2 Substrates with a Narrow Therapeutic Index ... MATE 2 Substrates ... OCT2 Substrates with a Narrow Therapeutic Index ... MATE 1 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP2D6 Substrates with a Narrow Therapeutic Index …
Etofamide is used as an antiamoebic agent. Etofamide, under the brand name Kitnos, was marketed in Brazil by Pfizer but has been discontinued .
Approved
Matched Iupac: … 2,2-dichloro-N-(2-ethoxyethyl)-N-{[4-(4-nitrophenoxy)phenyl]methyl}acetamide …
Matched Description: … Etofamide, under the brand name Kitnos, was marketed in Brazil by Pfizer but has been discontinued [L5617 …
Fidaxomicin is a novel macrolide antibiotic used in the treatment of diarrhea caused by Clostridioides (formerly Clostridium) difficile in adult and pediatric patients over the age of 6 months. Fidaxomicin is a naturally-occurring 18-member macrocycle derived from fermentation. Because fidaxomicin contains an 18-membered lactone ring in its structure, it is...
Approved
Matched Iupac: … -2-oxo-1-oxacyclooctadeca-3,5,9,13,15-pentaen-3-yl]methoxy}-4-hydroxy-5-methoxy-2-methyloxan-3-yl 3,5 ... (2R,3S,4S,5S,6R)-6-{[(3E,5E,8S,9E,11S,12R,13E,15E,18S)-12-{[(2R,3S,4R,5S)-3,4-dihydroxy-6,6-dimethyl- ... 5-[(2-methylpropanoyl)oxy]oxan-2-yl]oxy}-11-ethyl-8-hydroxy-18-[(1R)-1-hydroxyethyl]-9,13,15-trimethyl ... -dichloro-2-ethyl-4,6-dihydroxybenzoate …
Matched Description: … [A190516] The FDA initially approved fidaxomicin in May 2011 for the treatment of _C. difficile_-associated ... Fidaxomicin is a novel macrolide antibiotic used in the treatment of diarrhea caused by _Clostridioides ... as a macrocyclic lactone antibiotic drug. …
Having a chemical formula of F−, fluoride ion is the simplest inorganic, monatomic anion of fluorine with basic properties. It is considered a trace element. Fluoride ions are found in various minerals but are only present in trace amounts in water. Its various salt forms and minerals play numerous roles...
Approved
Matched Description: … Having a chemical formula of F−, fluoride ion is the simplest inorganic, monatomic anion of fluorine ... It is considered a trace element. ... Fluoride ions are found in various minerals but are only present in trace amounts in water. …
Matched Mixtures name: … ZYMAFLUOR D 500 C C
Fenpropidin has been investigated for the treatment of Hernia.
Approved
Experimental
Matched Iupac: … 1-{2-[(4-tert-butylphenyl)methyl]propyl}piperidine …
Matched Description: … Fenpropidin has been investigated for the treatment of Hernia. …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Flosequinan was approved in the USA and the UK for a year prior to being withdrawn from the market due to increased mortality in chronic heart failure patients, found in drug trials.[A174979,L43942]
Approved
Withdrawn
Matched Iupac: … 7-fluoro-3-methanesulfinyl-1-methyl-1,4-dihydroquinolin-4-one …
Matched Description: … Flosequinan was approved in the USA and the UK for a year prior to being withdrawn from the market due ... to increased mortality in chronic heart failure patients, found in drug trials. …
Matched Categories: … Heterocyclic Compounds, 2-Ring ... Vasodilators Used in Cardiac Diseases …
Osilodrostat is an inhibitor of 11β-hydroxylase (also referred to as CYP11B1), the enzyme that catalyzes the final step in the biosynthesis of endogenous cortisol. It is used to lower circulating cortisol levels in the treatment of Cushing's disease, a disorder in which cortisol levels are chronically and supraphysiologically elevated. Cushing's...
Approved
Investigational
Matched Iupac: … 3-fluoro-4-[(5R)-5H,6H,7H-pyrrolo[1,2-c]imidazol-5-yl]benzonitrile …
Matched Description: … [L12123] It is used to lower circulating cortisol levels in the treatment of Cushing's disease, a disorder ... in which cortisol levels are chronically and supraphysiologically elevated. ... [A191850] Osilodrostat was approved for use in the EU in January 2020 for the treatment of endogenous …
Ceftobiprole is a fifth-generation semisynthetic cephalosporin antibacterial which is available commercially as the prodrug ceftobiprole medocaril. Ceftobiprole is a broad-spectrum agent with demonstrated activity against both Gram-positive and Gram-negative bacteria, including antibiotic-resistant strains of Staphylcoccus aureus (methicillin-resistant Staphylococcus aureus; MRSA). The EMA's Committee for Medicinal Products for Human Use (CHMP)...
Approved
Investigational
Matched Iupac: … (6R,7R)-7-[(2Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-(N-hydroxyimino)acetamido]-8-oxo-3-{[(3E,3'R)-2-oxo ... -[1,3'-bipyrrolidin]-3-ylidene]methyl}-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid …
Matched Description: … The EMA's Committee for Medicinal Products for Human Use (CHMP) adopted a negative opinion of ceftobiprole ... [L50467] It received its first approval in Canada in October 2017 for use in certain patients with bacterial ... pneumonia,[L50472] and was subsequently approved in the United States with additional indications for
Matched Categories: … Heterocyclic Compounds, 2-Ring …
Chromium picolinate has a chemical formula CrPic3 and reddish-pink color. It is a coordination complex consisting of chromium(III) and picolinic acid. Chromium picolinate is used as a nutritional supplement for optimal insulin function in patients with Type 2 diabetes or promotion of weight loss. Chromium ions are shown to regulate...
Approved
Matched Iupac: … chromium(3+) tris(pyridine-2-carboxylate) …
Matched Description: … Chromium picolinate is used as a nutritional supplement for optimal insulin function in patients with ... Type 2 diabetes or promotion of weight loss. ... Chromium picolinate has a chemical formula CrPic3 and reddish-pink color. …
Matched Mixtures name: … BLACKMORES teen multi for GUYS capsule …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Ebola virus vaccine is a vaccine used to prevent Ebola virus disease caused by Zaire ebolavirus in adults, prevent outbreaks, and reduce the extent of the virus spreading in case of outbreaks. Ebola virus disease, formerly known as Ebola hemorrhagic fever, is a rare but severe and often deadly disease....
Approved
Matched Synonyms: … Recombinant Vesicular Stomatitis Virus (rVSV) strain Indiana with a deletion of the VSV envelope glycoprotein …
Matched Description: … [L10866] In 2014, Merck Inc. signed a licensing agreement with NewLink for further development and marketing ... Ebola virus vaccine is a vaccine used to prevent Ebola virus disease caused by _Zaire ebolavirus_ in ... [L10854] Ebola virus disease, formerly known as Ebola hemorrhagic fever, is a rare but severe and often …
Pentoxyverine, also referred to as carbetapentane, is a non-opioid central acting antitussive with antimuscarinic, anticonvulsant , and local anesthetic properties. It is an active ingredient in over-the-counter cough suppressants in combination with guaifenesin and H1-receptor antagonists . Pentoxyverine acts on sigma-1 receptors, as well as kappa and mu-opioid receptors. The...
Approved
Investigational
Withdrawn
Matched Iupac: … 2-[2-(diethylamino)ethoxy]ethyl 1-phenylcyclopentane-1-carboxylate …
Matched Description: … It is an active ingredient in over-the-counter cough suppressants in combination with guaifenesin and ... The FDA withdrew the use of all oral gel drug products containing pentoxyverine citrate. ... Pentoxyverine, also referred to as carbetapentane, is a non-opioid central acting antitussive with antimuscarinic …
Matched Mixtures name: … Pancold A ... C-Tanna 12D Suspension …
Citalopram is an antidepressant belonging to the class of selective serotonin-reuptake inhibitors (SSRIs) widely used to treat the symptoms of depression. It is a racemic bicyclic phthalate derivate and is the only compound with a tertiary amine and 2 nitrogen-containing metabolites among all SSRIs.[A261316,A14720] Citalopram enhances serotonergic transmission through the...
Approved
Matched Iupac: … 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile …
Matched Description: … [A261316] Citalopram was approved by the FDA in 1998 for the treatment of depression in adults 18 ... It is a racemic bicyclic phthalate derivate and is the only compound with a tertiary amine and 2 nitrogen-containing ... metabolites among all SSRIs. …
Matched Categories: … Monoamine Oxidase A Substrates ... Antidepressive Agents Indicated for Depression …
Molybdenum is a chemical element with symbol Mo and atomic number 42. As it is not a naturally occuring free metal on Earth, molybdenum is found only in various oxidation states in minerals. Molybdenum is commonly used in metallurgy and other chemical applications however it has essential biological roles in...
Approved
Matched Description: … As it is not a naturally occuring free metal on Earth, molybdenum is found only in various oxidation ... It is an essential trace dietary element and acts as a critical cofactor in several molybdenum-dependent ... When complexed with Technetium Tc 99m, molybdenum is used as a radiopharmaceutical agent in diagonistic …
Matched Mixtures name: … Ribotin-E ... Spectrum 2 Cap ... BION 3 FILM COATED TABLET …
Fruquintinib is a novel small-molecule anti-VEGFR that targets VEGFR-1,-2, and -3 to inhibit angiogenesis. Tumor angiogenesis is one of the most critical biological processes for increasing oxygen and nutrient supply to cancer cells, and the VEGF/VEGFR pathway is one of the most critical pathways for this phenomenon.[A262102,A262107] Indeed, oncogenic activation,...
Approved
Investigational
Matched Iupac: … 6-[(6,7-dimethoxyquinazolin-4-yl)oxy]-N,2-dimethyl-1-benzofuran-3-carboxamide …
Matched Description: … Fruquintinib is a novel small-molecule anti-VEGFR that targets VEGFR-1,-2, and -3 to inhibit angiogenesis ... in overall survival rate was observed in both trials. ... The first approach can be exemplified by [bevacizumab], a VEGF-A trap antibody. …
Matched Categories: … Heterocyclic Compounds, 2-Ring …
Human African trypanosomiasis (HAT, also colloquially referred to as sleeping sickness), caused by T. brucei gambiense and T. brucei rhodesiense, remains a moderate risk (>1/10,000 inhabitants per year in endemic areas) despite focussed control efforts. Transmitted by the bite of an infected tsetse fly, HAT is biphasic with a first...
Approved
Investigational
Matched Iupac: … 1-methyl-2-{[4-(methylsulfanyl)phenoxy]methyl}-5-nitro-1H-imidazole …
Matched Description: … rediscovered through the Drugs for Neglected Diseases Initiative (DNDi) in 2005, is the first all-oral ... that progresses to a second (meningoencephalitic) stage in which patients experience progressively worsening ... treatment for first and second stage HAT caused by _T. brucei gambiense_. …
Matched Categories: … MATE 2 Inhibitors ... MATE 2-K Inhibitors …
Ferric maltol is an iron(III) atom complexed with 3 maltol molecules to increase the bioavailability compared to iron(II), without depositing it in the duodenum as insoluble ferric hydroxide and phosphate. Ferric maltol has been described in literature since at least the late 1980s as a potential treatment for iron deficiency....
Approved
Matched Iupac: … iron(3+) tris(2-methyl-4-oxo-4H-pyran-3-olate) …
Matched Description: … [A189288] Ferric maltol has been described in literature since at least the late 1980s as a potential ... treatment for iron deficiency. ... Ferric maltol is an iron(III) atom complexed with 3 maltol molecules to increase the bioavailability …
Vasomotor symptoms (VMS), more colloquially known as hot flashes or night sweats, are some of the most common symptoms in menopause. With a median duration of 7.4 years, vasomotor symptoms are also the most common reasons why women seek treatments for menopausal issues.[A259591,A259596] Although mostly considered a nuisance, vasomotor symptoms...
Approved
Investigational
Matched Iupac: … 5-[(8R)-7-(4-fluorobenzoyl)-8-methyl-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazin-3-yl]-3-methyl-1,2,4-thiadiazole …
Matched Description: … effective treatments for VMS by relieving symptoms in as many as 95% of menopausal women. ... [L46422] It was subsequently approved by the EMA in December 2023 for the same indication.[L50086] ... quality of life, as women with 7 or more moderate to severe VMS daily have reported a decline in sleep …
Matched Categories: … Neurokinin 3 Receptor Antagonist …
Eplerenone, an aldosterone receptor antagonist similar to spironolactone, has been shown to produce sustained increases in plasma renin and serum aldosterone, consistent with inhibition of the negative regulatory feedback of aldosterone on renin secretion. The resulting increased plasma renin activity and aldosterone circulating levels do not overcome the effects of...
Approved
Matched Iupac: … methyl (1'R,2R,2'S,9'R,10'R,11'S,15'S,17'R)-2',15'-dimethyl-5,5'-dioxo-18'-oxaspiro[oxolane-2,14'-pentacyclo …
Matched Description: … aldosterone receptor antagonist similar to spironolactone, has been shown to produce sustained increases in ... The resulting increased plasma renin activity and aldosterone circulating levels do not overcome the …
Matched Categories: … Antihypertensive Agents Indicated for Hypertension …
Elotuzumab is a humanized IgG1 (Immunoglobulin G) monoclonal antibody indicated in combination with lenalidomide and dexamethasone for the treatment of patients with multiple myeloma who have received one to three prior therapies. Elotuzumab targets SLAMF7, also known as Signaling Lymphocytic Activation Molecule Family member 7, a cell surface glycoprotein. Elotuzumab...
Approved
Matched Description: … Elotuzumab has a theoretical mass of 148.1 kDa for the intact antibody. ... Elotuzumab is a humanized IgG1 (Immunoglobulin G) monoclonal antibody indicated in combination with lenalidomide ... Elotuzumab is produced in NS0 cells by recombinant DNA technology. …
Epicriptine is also known as beta-dihydroergocryptine presents a molecular formula of 9,10 alpha-dihydro-13'-epi-b-ergocryptine. Together with the alpha-dihydroergocryptine, it represents one-third of the ergoloid mesylate mixture. Epicriptine differs from the alpha form on the position of one methyl group. To know more about the mixture please visit DB01049
Approved
Matched Iupac: … (2R,4R,7R)-N-[(1S,2S,4R,7S)-7-[(2R)-butan-2-yl]-2-hydroxy-5,8-dioxo-4-(propan-2-yl)-3-oxa-6,9-diazatricyclo …
Matched Description: … Epicriptine is also known as beta-dihydroergocryptine presents a molecular formula of 9,10 alpha-dihydro …
Ruxolitinib, formerly known as INCB018424 or INC424, is an anticancer drug and a Janus kinase (JAK) inhibitor. It is a potent and selective inhibitor of JAK1 and JAK2, which are tyrosine kinases involved in cytokine signalling and hematopoiesis. Myeloproliferative neoplasms, such as myelofibrosis and polycythemia vera, are often characterized by...
Approved
Matched Iupac: … (3R)-3-cyclopentyl-3-(4-{7H-pyrrolo[2,3-d]pyrimidin-4-yl}-1H-pyrazol-1-yl)propanenitrile …
Matched Description: … [A229708] In 2014, it was approved for the treatment of polycythemia vera in adults who have an inadequate ... response to or are intolerant of [hydroxyurea] and in 2019, ruxolitinib was approved for use in steroid-refractory ... treatment for COVID-19. …
Matched Categories: … Agents for Dermatitis, Excluding Corticosteroids ... Cytochrome P-450 CYP2C9 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index …
Human papillomavirus type 58 L1 capsid protein antigen is contained in Gardasil is a vaccine for intramuscular injection. It is an immunization for young men and women 9-26 years of age for the prevention of diseases caused by Human Papillomavirus (HPV) type 58. The vaccine is prepared from the purified...
Approved
Matched Description: … Human papillomavirus type 58 L1 capsid protein antigen is contained in Gardasil is a vaccine for intramuscular ... It is an immunization for young men and women 9-26 years of age for the prevention of diseases caused ... (VLPs) of the major capsid (L1) protein of HPV Type 58 which are produced by separate fermentations in
Matched Mixtures name: … GARDASIL 9 SUSPENSION FOR INJECTION ... GARDASİL 9 IM ENJEKSİYONLUK SÜSPANSİYON, 1 ADET ŞIRINGA+2 ADET İĞNE …
Approved
Investigational
Matched Mixtures name: … 3 ANTIGEN ... ADACEL SUSPENSION FOR INJECTION ... FORMALDEHYDE INACTIVATED), BORDETELLA PERTUSSIS PERTACTIN ANTIGEN, and BORDETELLA PERTUSSIS FIMBRIAE 2/ …
Displaying drugs 826 - 850 of 15521 in total